Basophils getting on your nerves? Itching for clarity on flares in atopic dermatitis

2021 ◽  
Vol 6 (56) ◽  
pp. eabg8047
Author(s):  
Sarah E. Henrickson
Keyword(s):  
Atopic Dermatitis ◽  
Sensory Neurons ◽  
Neuroimmune Axis

Flares of acute itch in the setting of atopic dermatitis may engage a novel neuroimmune axis that includes basophils, LTC4, and sensory neurons.

scholarly journals Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Carolyn M Walsh ◽  
Rose Z Hill ◽  
Jamie Schwendinger-Schreck ◽  
Jacques Deguine ◽  
Emily C Brock ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Sensory Neurons ◽  
Treatment Options ◽  
Cellular Interactions ◽  
Immune Systems ◽  
Chronic Itch ◽  
Enhanced Expression ◽  
Neutrophil Depletion ◽  
Induced Genes ◽  
Neuropathic Itch

Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the development of itch and the acute-to-chronic itch transition remain unknown. Here, we show that skin-infiltrating neutrophils are key initiators of itch in atopic dermatitis, the most prevalent chronic itch disorder. Neutrophil depletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis. Neutrophils were also required for several key hallmarks of chronic itch, including skin hyperinnervation, enhanced expression of itch signaling molecules, and upregulation of inflammatory cytokines, activity-induced genes, and markers of neuropathic itch. Finally, we demonstrate that neutrophils are required for induction of CXCL10, a ligand of the CXCR3 receptor that promotes itch via activation of sensory neurons, and we find that that CXCR3 antagonism attenuates chronic itch.

scholarly journals Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

2019 ◽  
Author(s):  
Carolyn M. Walsh ◽  
Rose Z. Hill ◽  
Jamie Schwendinger-Schreck ◽  
Jacques Deguine ◽  
Emily C. Brock ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Sensory Neurons ◽  
Treatment Options ◽  
Cellular Interactions ◽  
Immune Systems ◽  
Chronic Itch ◽  
Enhanced Expression ◽  
Neutrophil Depletion ◽  
Induced Genes ◽  
Neuropathic Itch

AbstractChronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the development of itch and the acute-to-chronic itch transition remain unknown. Here, we show that skin-infiltrating neutrophils are key initiators of itch in atopic dermatitis, the most prevalent chronic itch disorder. Neutrophil depletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis. Neutrophils were also required for several key hallmarks of chronic itch, including skin hyperinnervation, enhanced expression of itch signaling molecules, and upregulation of inflammatory cytokines, activity-induced genes, and markers of neuropathic itch. Finally, we demonstrate that neutrophils are required for induction of CXCL10, a ligand of the CXCR3 receptor that promotes itch via activation of sensory neurons, and we find that that CXCR3 antagonism attenuates chronic itch.

scholarly journals Neuronal branching of sensory neurons is associated with BDNF‐positive eosinophils in atopic dermatitis

2020 ◽  
Vol 50 (5) ◽  
pp. 577-584 ◽  
Author(s):  
Daria Guseva ◽  
Urda Rüdrich ◽  
Nika Kotnik ◽  
Manuela Gehring ◽  
Nikolaos Patsinakidis ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Sensory Neurons

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

Diet and heredity in infantile atopic dermatitis

1972 ◽  
Vol 105 (3) ◽  
pp. 400-404 ◽  
Author(s):  
H. S. Kaufman
Keyword(s):  
Atopic Dermatitis
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