Organoid optimization: Engineering a better cell therapy to treat type 1 diabetes

2020 ◽  
Vol 12 (526) ◽  
pp. eaba2909
Author(s):  
Jessica D. Weaver
Keyword(s):  
Type 1 Diabetes ◽  
Cell Therapy ◽  
Diabetic Mice ◽  
Subcutaneous Space ◽  
And Function

Islet organoids reaggregated in endothelialized collagen constructs improve engraftment and function in the subcutaneous space in diabetic mice.

Cell therapy for type-1 diabetes

2009 ◽  
Vol 3 (6) ◽  
pp. 511-518
Author(s):  
I. B. Sokolova
Keyword(s):  
Type 1 Diabetes ◽  
Cell Therapy

scholarly journals Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e78687 ◽  
Author(s):  
Eric V. Marietta ◽  
Andres M. Gomez ◽  
Carl Yeoman ◽  
Ashenafi Y. Tilahun ◽  
Chad R. Clark ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Intestinal Microbiome ◽  
Gluten Free ◽  
Diabetic Mice ◽  
Low Incidence

scholarly journals The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1589
Author(s):  
Ryota Inoue ◽  
Kuniyuki Nishiyama ◽  
Jinghe Li ◽  
Daisuke Miyashita ◽  
Masato Ono ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Islet Cells ◽  
Autologous Transplantation ◽  
Insulin Injection ◽  
Islet Cell Transplantation ◽  
The Impact

Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes.

Mesenchymal stem cells: Stem cell therapy perspectives for type 1 diabetes

2009 ◽  
Vol 35 (2) ◽  
pp. 85-93 ◽  
Author(s):  
L. Vija ◽  
D. Farge ◽  
J.-F. Gautier ◽  
P. Vexiau ◽  
C. Dumitrache ◽  
...  
Keyword(s):  
Stem Cells ◽  
Type 1 Diabetes ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy
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