Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

2022 ◽  
Vol 14 (627) ◽  
Author(s):  
Yang Liu ◽  
Godwin Dzidotor ◽  
Thinh T. Le ◽  
Tra Vinikoor ◽  
Kristin Morgan ◽  
...  
Keyword(s):  
Cartilage Regeneration ◽  
Osteochondral Defects ◽  
Exercise Induced ◽  
And Cartilage

A biodegradable piezoelectric scaffold excited by exercise promotes chondrogenesis and cartilage regeneration in rabbit osteochondral defects.

Influence of Scaffold Stiffness on Subchondral Bone and Subsequent Cartilage Regeneration in an Ovine Model of Osteochondral Defect Healing

2008 ◽  
Vol 36 (12) ◽  
pp. 2379-2391 ◽  
Author(s):  
Karin Schlichting ◽  
Hanna Schell ◽  
Ralf U. Kleemann ◽  
Alexander Schill ◽  
Andreas Weiler ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Subchondral Bone ◽  
Cartilage Regeneration ◽  
Clinical Settings ◽  
Osteochondral Defects ◽  
Healthy Cartilage ◽  
Bearing Structure ◽  
Scaffold Group ◽  
And Cartilage

Background In osteochondral defects, subchondral bone, as a load-bearing structure, is believed to be important for bone and cartilage regeneration. Hypothesis A stiff scaffold creates better conditions for bone formation and cartilage regeneration than does a softer one. Study Design Controlled laboratory study. Methods Critical osteochondral defects were created in the femoral condyles of 24 sheep. Subchondral bone was reconstructed with a stiff scaffold or a modified softer one, with untreated defects serving as controls. The repair response was evaluated with mechanical, histological, and histomorphometrical techniques at 3 and 6 months postoperatively. Results The elastic modulus of regenerated fibrocartilage over the stiff scaffold tended to be higher than in the soft scaffold group (61 % vs 46% of healthy cartilage) at 3 months. No difference was determined at 6 months; all were well below healthy cartilage. Treated defects showed substantial degradation of the soft scaffold with surrounding sclerotic bone at 3 and 6 months. In contrast, degradation of the stiff scaffold was slower and occurred together with continuous osseous replacement. Conclusion Stiff scaffolds were found to improve bone regeneration. In contrast, soft scaffolds provided less support, and consequently subchondral bone became sclerotic. Although regenerated cartilage formed over the stiff scaffolds at 3 months, and these exhibited better mechanical properties than did the soft scaffold group, the mechanical properties in both treated groups were the same at 6 months, not dissimilar to that of tissue formed in the untreated specimens and inferior to native articular cartilage. Clinical Relevance The results imply that subchondral defect filling in clinical settings advances bone regeneration and should have a comparable stiffness to that of healthy subchondral bone rather than being too flexible. Degradation of resorbable materials and consequently the loss of stiffness may compromise the healing of critical defects.

scholarly journals Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review

2018 ◽  
Vol 4 (1) ◽  
pp. e000318 ◽  
Author(s):  
Ahmed Aly Elghawy ◽  
Carlos Sesin ◽  
Michael Rosselli
Keyword(s):  
Treatment Option ◽  
Platelet Rich Plasma ◽  
Cartilage Regeneration ◽  
Small Sample ◽  
Osteochondral Lesions ◽  
Osteochondral Defects ◽  
Eligibility Criteria ◽  
Surgical Options ◽  
Small Sample Sizes ◽  
Improve Patient

ObjectiveTo provide a review of osteochondral lesions of the talus, to discuss the evidence of the risks and benefits of platelet-rich plasma (PRP) as a viable treatment option, and to measure the efficacy of PRP using MRI evidence of cartilage regeneration, as well as scales that measure improvement in ‘pain’ and ‘functionality’.Eligibility criteriaStudies that use PRP in either conservative or intraoperative settings to treat osteochondral defects of the talus.ResultsThere are seven studies that compare hyaluronic acid or standard surgical options against PRP in treating osteochondral lesions of the talus. Five studies use PRP as supplemental treatment in intraoperative settings, while two studies use PRP conservatively as intra-articular injections. There were minimal adverse effects. Pain and functionality scores consistently improved in those who underwent PRP treatments over the course of 4 years. MRI showed significant but inconsistent results in chondral regeneration.ConclusionPRP may show clinical benefit in those with osteochondral lesions of the talus in terms of pain and functionality, although chondral regeneration via MRI is inconsistent. Limitations include the small sample sizes in these seven studies, as well as no standardised formula for PRP preparation.Clinical relevanceTo serve as an overview of the literature regarding PRP treatment for osteochondral lesions of the talus and how this modality may improve patient outcomes in pain, functionality and chondral regeneration. A case is reported to complement the subject review.

scholarly journals Progress and Applications of Polyphosphate in Bone and Cartilage Regeneration

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Yan Wang ◽  
Min Li ◽  
Pei Li ◽  
Haijun Teng ◽  
Dehong Fan ◽  
...  
Keyword(s):  
Cartilage Regeneration ◽  
High Energy ◽  
Cartilage Defects ◽  
Artificial Bone ◽  
Cellular Mechanisms ◽  
Inorganic Polyphosphate ◽  
Morphogenetic Effects ◽  
And Cartilage

Patients with bone and cartilage defects due to infection, tumors, and trauma are quite common. Repairing bone and cartilage defects is thus a major problem for clinicians. Autologous and artificial bone transplantations are associated with many challenges, such as limited materials and immune rejection. Bone and cartilage regeneration has become a popular research topic. Inorganic polyphosphate (polyP) is a widely occurring biopolymer with high-energy phosphoanhydride bonds that exists in organisms from bacteria to mammals. Much data indicate that polyP acts as a regulator of gene expression in bone and cartilage tissues and exerts morphogenetic effects on cells involved in bone and cartilage formation. Exposure of these cells to polyP leads to the increase of cytokines that promote the differentiation of mesenchymal stem cells into osteoblasts, accelerates the osteoblast mineralization process, and inhibits the differentiation of osteoclast precursors to functionally active osteoclasts. PolyP-based materials have been widely reported in in vivo and in vitro studies. This paper reviews the current cellular mechanisms and material applications of polyP in bone and cartilage regeneration.

scholarly journals Epigenetics and Cartilage Regeneration

2019 ◽  
Author(s):  
Samina Hyder Haq ◽  
Iqraa Haq ◽  
Atheer Ali Alsayah ◽  
Abir Alamro ◽  
Amani AlGhamedi
Keyword(s):  
Cartilage Regeneration ◽  
And Cartilage

Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells

2015 ◽  
Vol 15 (11) ◽  
pp. 1541-1552 ◽  
Author(s):  
Michail E Klontzas ◽  
Eustathios I Kenanidis ◽  
Manolis Heliotis ◽  
Eleftherios Tsiridis ◽  
Athanasios Mantalaris
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Cartilage Regeneration ◽  
And Cartilage
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