In VitroResponses of Acinetobacter baumannii to Two- and Three-Drug Combinations following Exposure to Colistin and Doripenem
2013 ◽
Vol 58
(2)
◽
pp. 1195-1199
◽
Keyword(s):
ABSTRACTWe comparedin vitrokilling of colistin, doripenem, and sulbactam by time-kill methods againstAcinetobacter baumanniiisolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistin-doripenem bactericidal activity against recurrent isolates was attenuated (mean log10kill, −5.74 versus −2.88;P= 0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (−5.65 versus −2.43;P= 0.04).
2011 ◽
Vol 55
(7)
◽
pp. 3603-3608
◽
2016 ◽
Vol 60
(11)
◽
pp. 6892-6895
◽
2016 ◽
Vol 60
(7)
◽
pp. 4342-4345
◽
2004 ◽
Vol 48
(11)
◽
pp. 4479-4481
◽
Keyword(s):
Keyword(s):
Keyword(s):
2019 ◽
Vol 6
(Supplement_2)
◽
pp. S562-S563