Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus
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New Drug
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ABSTRACT New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus. Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus. In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
2013 ◽
Vol 58
(2)
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pp. 1195-1199
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2011 ◽
Vol 55
(9)
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pp. 4482-4484
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2012 ◽
Vol 56
(9)
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pp. 4786-4792
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2018 ◽
Vol 62
(4)
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pp. e01505-17
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