In vitro activity of BMS-181184 compared with those of fluconazole and amphotericin B against various candida spp.
1996 ◽
Vol 40
(9)
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pp. 2229-2231
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Keyword(s):
We compared the in vitro activity of BMS-181184, the first compound of a new class of antifungal agents, the pradimicins, with those of fluconazole and amphotericin B against 64 clinical isolates of Candida species. MICs were determined by a microdilution method with high resolution medium for BMS-181184 and fluconazole and antibiotic medium no. 3 with 2% glucose for amphotericin B. MICs of BMS-181184 for all yeasts were in the range of 0.78 to 12.5 micrograms/ml. BMS-181184 was active against isolates resistant to other antifungal agents, consistent with a novel mode of action. Minimum fungicidal concentrations for 16 isolates showed that BMS-181184 was fungicidal. Clinical studies are now required to confirm its activity.
2002 ◽
Vol 46
(6)
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pp. 1723-1727
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Keyword(s):
1999 ◽
Vol 44
(5)
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pp. 697-700
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1999 ◽
Vol 43
(5)
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pp. 1264-1266
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Keyword(s):
1997 ◽
Vol 41
(5)
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pp. 1156-1157
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2007 ◽
Vol 51
(7)
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pp. 2587-2590
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Keyword(s):
Keyword(s):
2005 ◽
Vol 55
(5)
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pp. 692-698
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Keyword(s):
2000 ◽
Vol 44
(5)
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pp. 1242-1246
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1999 ◽
Vol 43
(2)
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pp. 295-299
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Keyword(s):