Effect of Lamivudine on Transmission of Human T-Cell Lymphotropic Virus Type 1 to Adult Peripheral Blood Mononuclear Cells In Vitro
2002 ◽
Vol 46
(9)
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pp. 3080-3083
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Keyword(s):
T Cell
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ABSTRACT The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven long-term growth of infected PBMC in vitro at concentrations (6.25 μM) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.
2008 ◽
Vol 62
(7)
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pp. 430-435
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2006 ◽
Vol 13
(5)
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pp. 547-552
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1994 ◽
Vol 180
(5)
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pp. 1973-1978
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1999 ◽
Vol 80
(4)
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pp. 857-861
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1994 ◽
Vol 170
(6)
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pp. 1376-1383
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1992 ◽
Vol 30
(4)
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pp. 905-910
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1990 ◽
Vol 28
(4)
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pp. 734-737
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1998 ◽
Vol 36
(6)
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pp. 1811-1813
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