scholarly journals Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines

2003 ◽  
Vol 47 (11) ◽  
pp. 3630-3633 ◽  
Author(s):  
Teresa Krakauer ◽  
Marilyn Buckley
Keyword(s):  
Cell Proliferation ◽  
Proinflammatory Cytokines ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
T Cell Proliferation ◽  
Peripheral Blood Mononuclear ◽  
Cytokines And Chemokines ◽  
Blood Mononuclear Cells ◽  
Anti Inflammatory ◽  
Pathogenic Effects

ABSTRACT Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

scholarly journals Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation

2004 ◽  
Vol 11 (3) ◽  
pp. 621-624 ◽  
Author(s):  
Teresa Krakauer
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Therapeutic Modality ◽  
T Cell Proliferation ◽  
Toxic Shock ◽  
Peripheral Blood Mononuclear ◽  
Caspase Inhibitors ◽  
Cytokines And Chemokines

ABSTRACT Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

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