Prodrugs of Cephalosporin RWJ-333441 (MC-04,546) with Improved Aqueous Solubility
2003 ◽
Vol 47
(6)
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pp. 2043-2046
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Keyword(s):
ABSTRACT To improve the aqueous solubility of anti-methicillin-resistant Staphylococcus aureus cephalosporin RWJ-333441 for parenteral administration, acyl derivatives of the C-3 primary amino group were prepared and evaluated for solubility, cleavage in serum in vitro, and conversion to RWJ-333441 in vivo. Improved solubility at physiologic pH values and release of RWJ-333441 in vitro and in vivo were observed for several prodrugs, including the aspartate derivative RWJ-333442.
2005 ◽
Vol 49
(6)
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pp. 2498-2500
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2004 ◽
Vol 96
(1)
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pp. 1-7
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1984 ◽
Vol 149
(6)
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pp. 894-903
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2020 ◽
Vol 199
(1)
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pp. 244-257
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2019 ◽
Vol 9
(3)
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pp. 496-504
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2016 ◽
Vol 60
(10)
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pp. 5688-5694
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2020 ◽
Vol 205
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pp. 112533
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