scholarly journals HLA and Infectious Diseases

2009 ◽  
Vol 22 (2) ◽  
pp. 370-385 ◽  
Author(s):  
Jenefer M. Blackwell ◽  
Sarra E. Jamieson ◽  
David Burgner
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Human Leukocyte Antigen ◽  
Molecular Basis ◽  
Selective Pressure ◽  
Human Leukocyte ◽  
Acquired Immunity ◽  
Leukocyte Antigen ◽  
Extreme Variability ◽  
Classical Human Leukocyte Antigen

SUMMARY Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease. Indeed, the original hypothesis for the extreme variability observed at HLA loci (H-2 in mice) was the major selective pressure from infectious diseases. Now that both the human genome and the molecular basis of innate and acquired immunity are understood in greater detail, do the classical HLA loci still stand out as major genes that determine susceptibility to infectious disease? This review looks afresh at the evidence supporting a role for classical HLA loci in susceptibility to infectious disease, examines the limitations of data reported to date, and discusses current advances in methodology and technology that will potentially lead to greater understanding of their role in infectious diseases in the future.

scholarly journals A Unique Regulation Region in the 3′ UTR of HLA-G with a Promising Potential

2020 ◽  
Vol 21 (3) ◽  
pp. 900 ◽  
Author(s):  
Adi Reches ◽  
Orit Berhani ◽  
Ofer Mandelboim
Keyword(s):  
Human Leukocyte Antigen ◽  
Expression Pattern ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Leukocyte Antigen ◽  
Distinct Site ◽  
Human Leukocyte Antigen G ◽  
Classical Human Leukocyte Antigen

Human leukocyte antigen G (HLA-G) is a non-classical human leukocyte antigen (HLA) class I protein that interacts with inhibitory receptors and is commonly overexpressed in various cancers, thereby establishing itself as an inhibitory checkpoint immune ligand. It is also expressed in trophoblast cells during pregnancy and protects the fetus from immune rejection. Despite its crucial role and its intriguing expression pattern, the regulation of HLA-G’s expression is only partially understood. HLA-G’s mRNA is expressed in many tissues but the protein expression is restricted only to the cells mentioned above. Therefore, we suggest that HLA-G is post-transcriptionally regulated. Here, we reveal a distinctive site present only in the 3′ Untranslated region (UTR) of HLA-G, which might explain its unique expression pattern. Consequently, we attempted to find binding factors such as RNA binding proteins (RBPs) and microRNAS (miRs) that regulate HLA-G expression by interacting with this distinct site present in its 3′ UTR. Our research indicates that this site should be further studied in order to reveal its significance.

scholarly journals Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

2008 ◽  
Vol 69 (7) ◽  
pp. 443-464 ◽  
Author(s):  
Owen D. Solberg ◽  
Steven J. Mack ◽  
Alex K. Lancaster ◽  
Richard M. Single ◽  
Yingssu Tsai ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Population Studies ◽  
Balancing Selection ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Analytic Review ◽  
Classical Human Leukocyte Antigen

scholarly journals The Association of Human Leukocyte Antigen and COVID-19 in Southern China

2021 ◽  
Author(s):  
Xueping Yu ◽  
Kuoting Ho ◽  
Zhongliang Shen ◽  
Xiaoying Fu ◽  
Hongbo Huang ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Immune Responses ◽  
Human Leukocyte Antigen ◽  
Southern China ◽  
Human Leukocyte ◽  
Viral Proteins ◽  
Binding Affinities ◽  
Hla Polymorphism ◽  
Leukocyte Antigen ◽  
Weak Binding

Abstract HLA polymorphism is hypothesized to be associated with diverse immune responses towards infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were associated with COVID-19 susceptibility in China. Both alleles were predicted to have weak binding affinities towards viral proteins.

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