scholarly journals Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Chad W. Johnston ◽  
Yongchang Li ◽  
Nathan A. Magarvey
Keyword(s):  
Drug Discovery ◽  
Genome Sequence ◽  
Draft Genome ◽  
Gene Clusters ◽  
Nonribosomal Peptides ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Vasopressin Receptors ◽  
Hormone Antagonists ◽  
Promising Source

Streptomyces silvensis produces nonribosomal peptides that act as antagonists of the human oxytocin and vasopressin receptors. Here, we present the genome sequence of S. silvensis ATCC 53525 and demonstrate that this organism possesses a number of additional biosynthetic gene clusters and might be a promising source for genome-guided drug discovery efforts.

scholarly journals Draft Genome Sequence of Streptomyces sp. Strain C8S0, Isolated from a Highly Oligotrophic Sediment

2020 ◽  
Vol 9 (14) ◽  
Author(s):  
S. Gallegos-Lopez ◽  
P. M. Mejia-Ponce ◽  
L. A. Gonzalez-Salazar ◽  
L. Rodriguez-Orduña ◽  
V. Souza-Saldivar ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Draft Genome ◽  
Gene Clusters ◽  
Draft Genome Sequence ◽  
Bioactive Metabolites ◽  
Nonribosomal Peptides ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Cuatro Ciénegas ◽  
Cuatro Ciénegas Basin

Streptomyces spp. are prolific bacteria producing bioactive metabolites. We present the draft genome sequence of Streptomyces sp. strain C8S0, which was isolated from a highly oligotrophic sediment from the Cuatro Cienegas Basin (Mexico). The whole-genome assembly comprised 6,898,902 bp, with 18 biosynthetic gene clusters, including those for nonconventional terpenes, nonribosomal peptides, and polyketides.

scholarly journals Draft Genome Sequence of an Anicemycin Producer, Streptomyces sp. TP-A0648

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Hisayuki Komaki ◽  
Akira Hosoyama ◽  
Akane Kimura ◽  
Natsuko Ichikawa ◽  
Yasuhiro Igarashi
Keyword(s):  
Genome Sequence ◽  
Draft Genome ◽  
Growth Inhibitor ◽  
Gene Clusters ◽  
Draft Genome Sequence ◽  
Nonribosomal Peptides ◽  
Tumor Cell Growth ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Aucuba Japonica

ABSTRACT We report the draft genome sequence of Streptomyces sp. TP-A0648 isolated from a leaf of Aucuba japonica. This strain produces a new tumor cell growth inhibitor designated anicemycin. The genome harbors at least 12 biosynthetic gene clusters for polyketides and nonribosomal peptides, suggesting the potential to produce diverse secondary metabolites.

scholarly journals Draft Genome Sequence of Geobacillus sp. LEMMY01, a Thermophilic Bacterium Isolated from the Site of a Burning Grass Pile

2017 ◽  
Vol 5 (19) ◽  
Author(s):  
Yuri Pinheiro Alves de Souza ◽  
Fábio Faria da Mota ◽  
Alexandre Soares Rosado
Keyword(s):  
Secondary Metabolites ◽  
Genome Sequence ◽  
Draft Genome ◽  
Axenic Culture ◽  
Gene Clusters ◽  
Thermophilic Bacterium ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Biotechnological Potential

ABSTRACT We report here the 3,586,065-bp draft genome of Geobacillus sp. LEMMY01, which was isolated (axenic culture) from a thermophilic chemolitoautotrophic consortium obtained from the site of a burning grass pile. The genome contains biosynthetic gene clusters coding for secondary metabolites, such as terpene and lantipeptide, confirming the biotechnological potential of this strain.

scholarly journals Draft Genome Sequence of Bacillus subtilis SB-14, an Antimicrobially Active Isolate from Namibian Social Spiders (Stegodyphus dumicola)

2019 ◽  
Vol 8 (25) ◽  
Author(s):  
Stine Sofie Frank Nielsen ◽  
Simone Weiss ◽  
Seven Nazipi ◽  
Ian P. G. Marshall ◽  
Trine Bilde ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Genome Sequence ◽  
Draft Genome ◽  
Gene Clusters ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
High Quality ◽  
Social Spider ◽  
Content Type

We present the high-quality draft genome sequence of Bacillus subtilis SB-14, isolated from the Namibian social spider Stegodyphus dumicola. In accordance with its antimicrobial activity, both known and potentially novel antimicrobial biosynthetic gene clusters were identified in the genome of SB-14.

scholarly journals Draft Genome Sequence of Kroppenstedtia sanguinis X0209T, a Clinical Isolate Recovered from Human Blood

2019 ◽  
Vol 8 (24) ◽  
Author(s):  
Robert A. Arthur ◽  
Ainsley C. Nicholson ◽  
Ben W. Humrighouse ◽  
John R. McQuiston ◽  
Brent A. Lasker
Keyword(s):  
Clinical Isolate ◽  
Genome Sequence ◽  
Human Blood ◽  
Draft Genome ◽  
Gene Clusters ◽  
Illumina Miseq ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Content Type

Kroppenstedtia sanguinis X0209T, a thermoactinomycete, was isolated from the blood of a patient in Sweden. We report on the draft genome sequence obtained with an Illumina MiSeq instrument. The assembled genome totaled 3.73 Mb and encoded 3,583 proteins. Putative genes for virulence, transposons, and biosynthetic gene clusters have been identified.

scholarly journals Draft Genome Sequence ofArthrobacter enclensisNCIM 5488Tfor Secondary Metabolism

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Priya S. Neurgaonkar ◽  
Mahesh S. Dharne ◽  
Syed G. Dastager
Keyword(s):  
Genome Sequence ◽  
Draft Genome ◽  
Gene Clusters ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Marine Sediment Sample ◽  
Chorao Island

Here, we report the draft genome sequence ofArthrobacter enclensisNCIM 5488T, an actinobacterium isolated from a marine sediment sample from Chorao Island, Goa, India. This draft genome sequence consists of 4,226,231 bp with a G+C content of 67.08%, 3,888 protein-coding genes, 50 tRNAs, and 10 rRNAs. Analysis of the genome using bioinformatics tools such as antiSMASH and NaPDoS showed the presence of many unique natural product biosynthetic gene clusters.

scholarly journals Draft Genome Sequence of Thermogemmatispora onikobensis NBRC 111776 T , an Aerial Mycelium- and Spore-Forming Thermophilic Bacterium Belonging to the Class Ktedonobacteria

2016 ◽  
Vol 4 (5) ◽  
Author(s):  
Hisayuki Komaki ◽  
Akira Hosoyama ◽  
Shuhei Yabe ◽  
Akira Yokota ◽  
Yoshihito Uchino ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Genome Sequence ◽  
Draft Genome ◽  
Aerial Mycelium ◽  
Gene Clusters ◽  
Thermophilic Bacterium ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Nonribosomal Peptide

Here, we report the draft genome sequence of Thermogemmatispora onikobensis NBRC 111776 T , an aerial mycelium- and spore-forming thermophilic bacterium belonging to the class Ktedonobacteria . The genome contains five biosynthetic gene clusters coding for secondary metabolites, such as terpene, thiopeptide, lantipeptide, nonribosomal peptide, and lassopeptide, suggesting the potential to produce secondary metabolites.

scholarly journals Draft Genome Sequence of Saccharomonospora piscinae KCTC 19743T, an Actinobacterium Containing Secondary Metabolite Biosynthetic Gene Clusters

2020 ◽  
Vol 9 (15) ◽  
Author(s):  
Ninfa Ramírez-Durán ◽  
Rafael R. de la Haba ◽  
Blanca Vera-Gargallo ◽  
Cristina Sánchez-Porro ◽  
Scarlett Alonso-Carmona ◽  
...  
Keyword(s):  
Genome Sequence ◽  
Polyketide Synthase ◽  
Draft Genome ◽  
Gene Clusters ◽  
Open Reading Frames ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Peptide Synthetase ◽  
Reading Frames

The draft genome sequence of Saccharomonospora piscinae KCTC 19743T, with a size of 4,897,614 bp, was assembled into 11 scaffolds containing 4,561 open reading frames and a G+C content of 71.0 mol%. Polyketide synthase and nonribosomal peptide synthetase gene clusters, which are responsible for the biosynthesis of several biomolecules, were identified and located in different regions in the genome.

scholarly journals Draft Genome Sequence of Streptomyces sp. TP-A0890, a Producer of FR-900452 and A-74863a

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Hisayuki Komaki ◽  
Natsuko Ichikawa ◽  
Akira Hosoyama ◽  
Nobuyuki Fujita ◽  
Yasuhiro Igarashi
Keyword(s):  
Genome Sequence ◽  
Polyketide Synthase ◽  
Sequence Similarity ◽  
Draft Genome ◽  
Gene Clusters ◽  
Draft Genome Sequence ◽  
Biosynthetic Gene ◽  
Biosynthetic Gene Clusters ◽  
Peptide Synthetase ◽  
Gene Functions

Here, we report the draft genome sequence of Streptomyces sp. TP-A0890, a producer of FR-900452 and A-74863a. The genome was found to contain at least eight polyketide synthase and nonribosomal peptide synthetase gene clusters. A prediction of gene functions based on the sequence similarity allowed us to assign the biosynthetic gene clusters for FR-900452 and A-74863a.

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