Platelet aggregation by hepatitis B surface antigen-antibody complexes.

Objectives. To determine hepatitis B virus (HBV) carrier and infection rates and HBV epidemiology in Honolulu students. Design. Cross-sectional survey. Setting. Honolulu public elementary, intermediate, and high schools. Patients. A volunteer sample of 4936 students from 43 Honolulu schools. Main outcome measures. HBV carrier rate (presence of hepatitis B surface antigen) and infection rate (presence of either hepatitis B surface antigen, antibody to hepatitis B surface antigen, antibody to hepatitis B core antigen, or any combinations of these) by school grade, ethnicity, and place of birth. Results. Eighty-three (1.68%) students were identified as HBV carriers, and a total of 353 (7.15%) students had serologic evidence of infection. Infection rates increased from elementary school age to high school age, more so in Asian/Pacific Island-born students. The prevalence of infection was higher in Asian/Pacific Island-born students than in those born in the United States. The majority of infected Hawaiian-born students were first-generation Asian/Pacific Island Americans. Conclusions. Horizontal transmission of HBV occurs in Honolulu school-age children. HBV immunization of all infants in Hawaii, not just those born to carrier mothers, is necessary to reduce HBV transmission in Hawaii.

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Response of patients with chronic Hepatitis B in one year of treatment with Major Autohemotherapy.

Journal of Ozone Therapy ◽

10.7203/jo3t.2.3.2018.11459 ◽

2018 ◽

Vol 2 (3) ◽

Cited By ~ 2

Author(s):

Javier Cespedes-Suarez ◽

Yanisley Martin-Serrano ◽

Maria Rosa Carballosa-Peña ◽

Diana Rosa Dager-Carballosa

Keyword(s):

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Surface Antigen ◽

Hepatitis B Surface Antigen ◽

Adult Population ◽

Antiviral Treatment ◽

Ozone Therapy ◽

Antigen Antibody

The Hepatitis B (HVB) is one of the most common infectious diseases in the world, it’s wide geographical distribution is a health problem, especially on the African continent, with prevalence rate of 6.1% in the adult population. Current treatment requires prolonged therapy (most cases for the rest of life) with the aim of stopping viral replication, maintaining immunological stability, preventing progression of liver disease and the most feared complications such as cirrhosis and hepatic cancer There are multiple references that point to ozone therapy as an alternative in the treatment of Hepatitis B, because of the known and demonstrated antimicrobial and immunomodulatory properties. With these premises, we performed the present clinical study that included 28 patients with positive diagnosis of chronic Hepatitis B, surface antigen (HVBs Ag) positive, antibodies against surface antigen (HVBs) negative, viral load (HVB DNA ) and transaminaseselevated. These patients with 1 year of evolution and antiviral treatment were treated with Major Autohemotherapy with protocol of 15 sessions and maintenance every 15 days to 50 mcg of concentration, initial dose of 4,000 mcg / ml up to 12,000 mcg /ml We indicate Ag HVBs, Ac HVBs, HVB Viral Loading and transaminases before starting treatment at 15 days of completion and quarterly until the year. The results showed negativization of the surface antigen, antibody positivity against the surface antigen, significant decrease of viral load to undetectable values and normal values of the transaminases demonstrating the functional recovery of the disease associated with favorable immunological response providing a better quality of patients' lives. Key words: Hepatitis B, Transaminases, Ozone therapy, Major Autohemotherapy, Surface antigen, Surface Antigen Antibody.

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