scholarly journals Nucleotide sequence comparison between heat-labile toxin B-subunit cistrons from Escherichia coli of human and porcine origin.

1985 ◽  
Vol 48 (1) ◽  
pp. 73-77 ◽  
Author(s):  
J Leong ◽  
A C Vinal ◽  
W S Dallas
Keyword(s):  
Escherichia Coli ◽  
Nucleotide Sequence ◽  
Sequence Comparison ◽  
Toxin B ◽  
Nucleotide Sequence Comparison ◽  
B Subunit ◽  
Heat Labile ◽  
Porcine Origin

Expression and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile Toxin B Subunit in Transgenic Rice Callus

2009 ◽  
Vol 44 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Tae-Geum Kim ◽  
Bang-Geul Kim ◽  
Mi-Young Kim ◽  
Jae-Kwon Choi ◽  
Eun-Sun Jung ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Transgenic Rice ◽  
Enterotoxigenic Escherichia Coli ◽  
Rice Callus ◽  
Toxin B ◽  
B Subunit ◽  
Heat Labile

Protective efficacy of a Mycoplasma pneumoniae P1C DNA vaccine fused with the B subunit of Escherichia coli heat-labile enterotoxin

2012 ◽  
Vol 58 (6) ◽  
pp. 802-810 ◽  
Author(s):  
Cuiming Zhu ◽  
Shiping Wang ◽  
Shihai Hu ◽  
Minjun Yu ◽  
Yanhua Zeng ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Mycoplasma Pneumoniae ◽  
Dna Vaccine ◽  
Protective Efficacy ◽  
Interferon Γ ◽  
Toxin B ◽  
B Subunit ◽  
Heat Labile ◽  
Carboxy Terminal Region ◽  
Carboxy Terminal

In the present study, we investigated the immunomodulatory responses of a DNA vaccine constructed by fusing Mycoplasma pneumoniae P1 protein carboxy terminal region (P1C) with the Escherichia coli heat-labile toxin B subunit (LTB). BALB/c mice were immunized by intranasal inoculation with control DNAs, the P1C DNA vaccine or the LTB–P1C fusion DNA vaccine. Levels of the anti-M. pneumoniae antibodies and levels of interferon-γ and IL-4 in mice were increased significantly upon inoculation of the LTB–P1C fusion DNA vaccine when compared with the inoculation with P1C DNA vaccine. The LTB–P1C fusion DNA vaccine efficiently enhanced the M. pneumoniae-specific IgA and IgG levels. The IgG2a/IgG1 ratio was significantly higher in bronchoalveolar lavages fluid and sera from mice fusion with LTB and P1C than mice receiving P1C alone. When the mice were challenged intranasally with 107 CFU M. pneumoniae strain (M129), the LTB–P1C fusion DNA vaccine conferred significantly better protection than P1C DNA vaccine (P < 0.05), as suggested by the results, such as less inflammation, lower histopathological score values, lower detectable number of M. pneumoniae strain, and lower mortality of challenging from 5 × 108 CFU M. pneumoniae. These results indicated that the LTB–P1C fusion DNA vaccine efficiently improved protective efficacy against M. pneumoniae infection and effectively attenuated development of M. pneumoniae in mice.

scholarly journals Low-Dose Exposure and Immunogenicity of Transgenic Maize Expressing the Escherichia coli Heat-Labile Toxin B Subunit

2007 ◽  
Vol 115 (3) ◽  
pp. 354-360 ◽  
Author(s):  
April J. Beyer ◽  
Kan Wang ◽  
Amber N. Umble ◽  
Jeffrey D. Wolt ◽  
Joan E. Cunnick
Keyword(s):  
Escherichia Coli ◽  
Low Dose ◽  
Transgenic Maize ◽  
Toxin B ◽  
B Subunit ◽  
Heat Labile

scholarly journals The B subunits of cholera and Escherichia coli heat-labile toxins enhance the immune responses in mice orally immunised with a recombinant live P-fimbrial vaccine for avian pathogenic E. coli

2014 ◽  
Vol 62 (3) ◽  
pp. 293-303
Author(s):  
In-Gyeong Oh ◽  
Chetan Jawale ◽  
John Lee
Keyword(s):  
Escherichia Coli ◽  
Immune Responses ◽  
Cholera Toxin B Subunit ◽  
Adjuvant Effect ◽  
Toxin B ◽  
E Coli ◽  
Cholera Toxin B ◽  
B Subunit ◽  
Heat Labile ◽  
Enterotoxin B

This study aimed to investigate the adjuvant effect of recombinant attenuatedSalmonellaexpressing cholera toxin B subunit (CTB) andEscherichia coliheat-labile enterotoxin B subunit (LTB) for the P-fimbriae subunit-based vaccine of avian pathogenicE. coli(APEC) in a murine model. The PapA-specific sIgA and IgG responses were significantly enhanced after immunisation with theSalmonella-PapA vaccine in the presence of CTB or LTB. The group immunised with theSalmonella-LTB strain promoted Th1-type immunity, whereas that immunised with theSalmonella-CTB strain produced Th2-type immunity. We concluded that bothSalmonella-CTB and -LTB strains can enhance the immune response to PapA, and that the LTB strain may be a more effective adjuvant for APEC vaccination, which requires higher Th1-type immunity for protection. Thus, our findings provide evidence that immunisation with an adjuvant, LTB, is one of the strategies of developing effective vaccines against P-fimbriated APEC.

scholarly journals A completely synthetic toxoid vaccine containing Escherichia coli heat-stable toxin and antigenic determinants of the heat-labile toxin B subunit.

1985 ◽  
Vol 48 (3) ◽  
pp. 735-740 ◽  
Author(s):  
R A Houghten ◽  
R F Engert ◽  
J M Ostresh ◽  
S R Hoffman ◽  
F A Klipstein
Keyword(s):  
Escherichia Coli ◽  
Antigenic Determinants ◽  
Toxin B ◽  
B Subunit ◽  
Heat Stable ◽  
Heat Labile

scholarly journals Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.

1996 ◽  
Vol 64 (4) ◽  
pp. 1290-1298 ◽  
Author(s):  
I Takahashi ◽  
H Kiyono ◽  
R J Jackson ◽  
K Fujihashi ◽  
H F Staats ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Oral Vaccine ◽  
Toxin B ◽  
B Subunit ◽  
Heat Labile
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