scholarly journals Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

1998 ◽  
Vol 66 (12) ◽  
pp. 6030-6034 ◽  
Author(s):  
Michel Arock ◽  
Elaine Ross ◽  
René Lai-Kuen ◽  
Geneviève Averlant ◽  
Zhimin Gao ◽  
...  
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Human Mast Cells ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.

Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

2011 ◽  
Vol 9 (1) ◽  
pp. 17-22 ◽  
Author(s):  
A. Saggini ◽  
D. Tripodi ◽  
G. Maccauro ◽  
M.L. Castellani ◽  
A. Anogeianaki ◽  
...  
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Giardia lamblia: Interleukin 6 and tumor necrosis factor-alpha release from mast cells induced through an Ig-independent pathway

2010 ◽  
Vol 126 (3) ◽  
pp. 298-303 ◽  
Author(s):  
Samira Muñoz-Cruz ◽  
Argelia Gómez-García ◽  
Jarenny Millán-Ibarra ◽  
Silvia Giono-Cerezo ◽  
Lilián Yépez-Mulia
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Giardia Lamblia ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Action of Tumor Necrosis Factor-alpha on Rat Mast Cells

2000 ◽  
Vol 20 (4) ◽  
pp. 377-382 ◽  
Author(s):  
Ewa Brzezinska-Blaszczyk ◽  
Marek Forczmanski ◽  
Anna Pietrzak
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Rat Mast Cells

scholarly journals Auricular Chondritis Caused by Metal Ear Tagging in C57BL/6 Mice

2007 ◽  
Vol 44 (4) ◽  
pp. 458-466 ◽  
Author(s):  
M. Kitagaki ◽  
M. Hirota
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interferon Gamma ◽  
Tumor Necrosis ◽  
Cellular Interactions ◽  
Necrosis Factor Alpha ◽  
Auricular Chondritis ◽  
Factor Alpha ◽  
Necrosis Factor

Although it has been shown that auricular chondritis in rats is caused by the use of metal identification ear tags, the pathogenesis remains unclear. Based on the hypothesis that the auricular chondritis is caused by metal ions released from metal identification ear tags, we investigated the pathogenesis in male C57BL/6 mice tagged with metal identification ear tags. Twenty-six weeks after the attachment of the ear tags, visible increases in the thickness of the auricle were observed, and the concentrations of copper and iron in the tagged ears were significantly increased ( P <.05) in the tagged ears compared with the untagged ears. There was up-regulation of metallothionein (MT)-I and MT-II mRNA in the tagged ears, and this was confirmed by immunohistologic staining of the destroyed cartilage. Histopathologically, there were observed severe chondritis with extensive granulomatous inflammation, newly formed cartilage nodules, and osseous metaplasia accompanied by cellular infiltrates, such as CD4 T lymphocyte, macrophages, neutrophils, and mast cells, and expression of Th1 cytokines, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-2 in the tagged ear. Based on these results, we concluded that the release of copper and iron ions from the metal ear tags played a major role in the onset of auricular chondritis. Subsequent cellular interactions, such as CD4 T cells, macrophages, fibroblasts, and mast cells, mediated by cytokines, such as tumor necrosis factor-alpha and interferon-gamma, caused an autoimmune response that may have led to the progression of auricular chondritis as an autoimmune disease.

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