scholarly journals Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice.

1991 ◽  
Vol 59 (6) ◽  
pp. 2110-2115 ◽  
Author(s):  
M A Freudenberg ◽  
C Galanos
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Gram Positive ◽  
Necrosis Factor Alpha ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Phagocytic and Tumor Necrosis Factor Alpha Response of Human Mast Cells following Exposure to Gram-Negative and Gram-Positive Bacteria

1998 ◽  
Vol 66 (12) ◽  
pp. 6030-6034 ◽  
Author(s):  
Michel Arock ◽  
Elaine Ross ◽  
René Lai-Kuen ◽  
Geneviève Averlant ◽  
Zhimin Gao ◽  
...  
Keyword(s):  
Mast Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Human Mast Cells ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.

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