Expression of AniA, the Major Anaerobically Induced Outer Membrane Protein of Neisseria gonorrhoeae, Provides Protection against Killing by Normal Human Sera
2000 ◽
Vol 68
(7)
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pp. 4368-4369
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Keyword(s):
ABSTRACT Anaerobically grown Neisseria gonorrhoeae has previously been shown to have elevated serum resistance in the absence of exogenous CMP-N-acetylneuraminic acid or detectable sialylation. We hypothesized that the anaerobically induced gonococcal outer membrane protein AniA might have a role in this phenomenon, as it is the only known gonococcal protein that is absent under aerobic conditions. An N. gonorrhoeae F62 derivative, RUG7035, in which aniA is under control of the tacpromoter, was used to examine the effect of AniA expression on serum resistance. In this study, we found that expression of AniA enhanced the serum resistance of N. gonorrhoeae and may account for these earlier observations.
1986 ◽
Vol 164
(5)
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pp. 1735-1748
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Keyword(s):
1992 ◽
Vol 60
(3)
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pp. 989-997
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2011 ◽
Vol 326
(2)
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pp. 109-115
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2000 ◽
Vol 68
(11)
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pp. 6250-6256
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2006 ◽
Vol 22
(7)
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pp. 693-700
1992 ◽
Vol 89
(12)
◽
pp. 5512-5516
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Keyword(s):
1980 ◽
Vol 138
(7)
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pp. 978-980
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Keyword(s):