First Report of Chronic Pulmonary Infection by KPC-3-Producing and Colistin-Resistant Klebsiella pneumoniae Sequence Type 258 (ST258) in an Adult Patient with Cystic Fibrosis: TABLE 1

The spread ofKlebsiella pneumoniaecarbapenemase (KPC)-producingK. pneumoniaecontinues to increase, and the possible development of KPC-producingK. pneumoniaeinfections in cystic fibrosis (CF) patients is a matter of concern. Here, we describe the establishment of a chronic lung infection due to a colistin-resistant KPC-producingK. pneumoniaeisolate in an Italian CF patient.

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Draft Genome Sequence for Pseudomonas aeruginosa Strain PAO579, a Mucoid Derivative of PAO381

Journal of Bacteriology ◽

10.1128/jb.01406-12 ◽

2012 ◽

Vol 194 (23) ◽

pp. 6617-6617 ◽

Cited By ~ 4

Author(s):

T. Ryan Withers ◽

Shannon L. Johnson ◽

Hongwei D. Yu

Keyword(s):

Cystic Fibrosis ◽

Pseudomonas Aeruginosa ◽

Genome Sequence ◽

Draft Genome ◽

Opportunistic Pathogen ◽

Lung Infection ◽

Draft Genome Sequence ◽

Content Type ◽

Chronic Lung Infection

ABSTRACTPseudomonas aeruginosais an opportunistic pathogen that establishes a chronic lung infection in individuals afflicted with cystic fibrosis. Here, we announce the draft genome ofP. aeruginosastrain PAO579, an alginate-overproducing derivative of strain PAO381.

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Outbreak of NDM-1-Producing Klebsiella pneumoniae in a Neonatal Unit in Colombia

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01447-12 ◽

2013 ◽

Vol 57 (4) ◽

pp. 1957-1960 ◽

Cited By ~ 62

Author(s):

Javier Antonio Escobar Pérez ◽

Narda María Olarte Escobar ◽

Betsy Castro-Cardozo ◽

Ismael Alberto Valderrama Márquez ◽

Martha Isabel Garzón Aguilar ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

South America ◽

Molecular Analysis ◽

Multilocus Sequence Typing ◽

Sequence Type ◽

Neonatal Unit ◽

Content Type ◽

First Report ◽

Sequence Types

ABSTRACTSix multiresistant, NDM-1-producingKlebsiella pneumoniaestrains were recovered from an outbreak that affected six neonatal patients in a Colombian hospital. Molecular analysis showed that all of the isolates harbored theblaNDM-1,qnrA, andintI1genes and were clonally related. Multilocus sequence typing showed that the isolates belonged to a new sequence type (ST1043) that was different from the sequence types that had previously been reported. This is the first report of NDM-1-producing isolates in South America.

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Klebsiella pneumoniae Sequence Type 11 from Companion Animals Bearing ArmA Methyltransferase, DHA-1 β-Lactamase, and QnrB4

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00491-13 ◽

2013 ◽

Vol 57 (9) ◽

pp. 4532-4534 ◽

Cited By ~ 29

Author(s):

Laura Hidalgo ◽

Belen Gutierrez ◽

Cristina M. Ovejero ◽

Laura Carrilero ◽

Stephanie Matrat ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Multilocus Sequence Typing ◽

Companion Animals ◽

Multidrug Resistant ◽

Sequence Type ◽

Resistance Determinant ◽

Epidemic Clone ◽

Content Type ◽

First Report

ABSTRACTSevenKlebsiella pneumoniaeisolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as ST11, a human epidemic clone reported worldwide and associated with, among others, OXA-48 and NDM carbapenemases. In the seven strains,armAwas borne by an IncR plasmid, pB1025, of 50 kb. The isolates were found to coproduce DHA-1 and SHV-11 β-lactamases, as well as the QnrB4 resistance determinant. This first report of the ArmA methyltransferase in pets illustrates their importance as a reservoir for human multidrug-resistantK. pneumoniae.

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Activity of Pyocin S2 against Pseudomonas aeruginosa Biofilms

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.05714-11 ◽

2011 ◽

Vol 56 (3) ◽

pp. 1599-1601 ◽

Cited By ~ 32

Author(s):

Karen Smith ◽

Laura Martin ◽

Angela Rinaldi ◽

Ranjith Rajendran ◽

Gordon Ramage ◽

...

Keyword(s):

Cystic Fibrosis ◽

Pseudomonas Aeruginosa ◽

Lung Function ◽

Therapeutic Option ◽

Lung Infection ◽

Content Type ◽

Highly Active ◽

Invertebrate Model ◽

Chronic Lung Infection

ABSTRACTIn cystic fibrosis patients, chronic lung infection withPseudomonas aeruginosaand the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity againstP. aeruginosabiofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model ofP. aeruginosainfection, we also show that pyocin S2 is highly activein vivo.

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Clonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae in Neonates

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00385-17 ◽

2017 ◽

Vol 61 (8) ◽

Cited By ~ 15

Author(s):

Dandan Yin ◽

Dong Dong ◽

Ke Li ◽

Lei Zhang ◽

Jianliang Liang ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Sequence Type ◽

Clinical Isolates ◽

Content Type ◽

First Report ◽

Clone Sequence

ABSTRACT Five OXA-232 carbapenemase-producing Klebsiella pneumoniae isolates, belonging to the pandemic clone sequence type 15 (ST15), were isolated from neonates and coproduced bla CTX-M-15 and bla SHV-1 genes. All isolates were resistant to ertapenem (MICs of >32 μg/ml) and meropenem (MICs of 4 to 8 μg/ml) and susceptible or intermediate to imipenem (MICs of 1 to 2 μg/ml). The bla OXA-232 gene was located on a ColE-type transformable plasmid of 6,141 bp. To the best of our knowledge, this is the first report of OXA-232 carbapenemase among clinical isolates in China.

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Faculty Opinions recommendation of Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1065903.518850 ◽

2007 ◽

Author(s):

Joanna Goldberg

Keyword(s):

Cystic Fibrosis ◽

Pseudomonas Aeruginosa ◽

Interleukin 1 ◽

Lung Infection ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Cystic Fibrosis Transmembrane ◽

Chronic Lung Infection

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Emergence and Recovery of Ceftazidime-avibactam Resistance in blaKPC-33-Harboring Klebsiella pneumoniae Sequence Type 11 Isolates in China

Clinical Infectious Diseases ◽

10.1093/cid/ciaa1521 ◽

2020 ◽

Vol 71 (Supplement_4) ◽

pp. S436-S439

Author(s):

Qingyu Shi ◽

Dandan Yin ◽

Renru Han ◽

Yan Guo ◽

Yonggui Zheng ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Infection Control ◽

Polymyxin B ◽

Sequence Type ◽

First Report ◽

Clinical Strains

Abstract This is the first report of ceftazidime–avibactam resistance caused by the blaKPC-33 mutation through the D179Y variant during the treatment of blaKPC-2-positive Klebsiella pneumoniae-related infections in China. The blaKPC-33-containing K. pneumoniae was susceptible to meropenem–vaborbactam, cefepime–zidebactam, tigecycline, and polymyxin B. The blaKPC-33 gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and blaLAP-2. Detecting blaKPC-33-positive K. pneumoniae clinical strains is important for infection control.

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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00404-17 ◽

2017 ◽

Vol 61 (8) ◽

Cited By ~ 2

Author(s):

Astrid V. Cienfuegos-Gallet ◽

Liang Chen ◽

Barry N. Kreiswirth ◽

J. Natalia Jiménez

Keyword(s):

Klebsiella Pneumoniae ◽

Plasmid Dna ◽

Clonal Expansion ◽

Genetic Alterations ◽

Sequence Type ◽

Chromosomal Integration ◽

Colistin Resistance ◽

Content Type ◽

Carbapenem Resistant ◽

Single Locus Variant

ABSTRACT Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.

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Doripenem MICs andompK36Porin Genotypes of Sequence Type 258, KPC-Producing Klebsiella pneumoniae May Predict Responses to Carbapenem-Colistin Combination Therapy among Patients with Bacteremia

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.03894-14 ◽

2014 ◽

Vol 59 (3) ◽

pp. 1797-1801 ◽

Cited By ~ 23

Author(s):

Ryan K. Shields ◽

M. Hong Nguyen ◽

Brian A. Potoski ◽

Ellen G. Press ◽

Liang Chen ◽

...

Keyword(s):

Amino Acids ◽

Combination Therapy ◽

Klebsiella Pneumoniae ◽

Sequence Type ◽

Content Type

ABSTRACTTreatment failures of a carbapenem-colistin regimen among patients with bacteremia due to sequence type 258 (ST258), KPC-2-producingKlebsiella pneumoniaewere significantly more likely if both agents were inactivein vitro, as defined by a colistin MIC of >2 μg/ml and the presence of either a majorompK36porin mutation (guanine and alanine insertions at amino acids 134 and 135 [ins aa 134–135 GD], IS5promoter insertion [P= 0.007]) or a doripenem MIC of >8 μg/ml (P= 0.01). MajorompK36mutations among KPC-K. pneumoniaestrains are important determinants of carbapenem-colistin responsesin vitroandin vivo.

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