Hepatitis C Virus Infection Modulates Expression of Interferon Stimulatory Gene IFITM1 by Upregulating miR-130A
Keyword(s):
We have examined the underlying mechanism of hepatitis C virus (HCV)-mediated IFITM1 regulation. IFITM1 is a potential target of miR-130a. Our results demonstrated that miR-130a expression was significantly higher in HCV-infected hepatocytes and liver biopsy specimens than in controls. Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a and that use of anti-miR-130a may have potential for restriction of HCV replication.
2009 ◽
Vol 41
(6)
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pp. 2425-2426
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1997 ◽
Vol 56
(6)
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pp. 390-392
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2020 ◽
Vol 34
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pp. 205873842096120
Seroepidemiology of hepatitis C virus infection in Japan and HCV infection in haemodialysis patients
1994 ◽
Vol 14
(3)
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pp. 253-258
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Keyword(s):
2008 ◽
Vol 46
(4)
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pp. 423-428
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2006 ◽
Vol 80
(10)
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pp. 5097-5099
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