Intra- and Intersubtype Alternative Pak2-Activating Structural Motifs of Human Immunodeficiency Virus Type 1 Nef
Keyword(s):
ABSTRACT The design of antiviral strategies against human immunodeficiency virus type 1 (HIV-1) has been largely derived from studies of subtype B viruses, although they constitute only 12% of infections worldwide. At 50% of all HIV-1 infections worldwide, subtype C viruses are the most predominant. Here, we present evidence that subtype C Nefs display functional Pak2-activating motifs that differ from those found in subtype B and E Nefs. The identification of multiple Pak2-activating structural motifs that singly affect one Nef activity revealed a functional plasticity that has implications for future drug and vaccine design aimed at HIV-1 Nef and its effects on the deregulation of the immune system.
2000 ◽
Vol 74
(23)
◽
pp. 11286-11295
◽
2003 ◽
Vol 77
(6)
◽
pp. 3832-3837
◽
Keyword(s):
1999 ◽
Vol 73
(5)
◽
pp. 4427-4432
◽
Keyword(s):
2005 ◽
Vol 21
(5)
◽
pp. 379-394
◽
1999 ◽
Vol 73
(1)
◽
pp. 152-160
◽
Keyword(s):
2004 ◽
Vol 78
(6)
◽
pp. 2841-2852
◽
2006 ◽
Vol 80
(10)
◽
pp. 4698-4704
◽
2009 ◽
Vol 54
(2)
◽
pp. 907-911
◽
2003 ◽
Vol 77
(2)
◽
pp. 1021-1038
◽