Neuraminidase-Inhibiting Antibody Is a Correlate of Cross-Protection against Lethal H5N1 Influenza Virus in Ferrets Immunized with Seasonal Influenza Vaccine

Virus strains in the seasonal influenza vaccine for the 2014/15 northern hemisphere season remained unchanged from those in 2013/14. During spring 2014, drifted influenza A(H3N2) viruses, subgroup 3C.3a, were detected in Finland; another subgroup, 3C.2a, emerged in the 2014/15 season and has predominated. We monitored antibody responses against vaccine and epidemic strains (2013/14 and 2014/15) among Finnish healthcare workers after influenza vaccination with the 2013/14 vaccine. The data suggest reduced cross-protection towards both subgroups of drifted A(H3N2) viruses.

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Cross-clade protection against HPAI H5N1 influenza virus challenge in BALB/c mice intranasally administered adjuvant-combined influenza vaccine

Veterinary Microbiology ◽

10.1016/j.vetmic.2010.03.024 ◽

2010 ◽

Vol 146 (1-2) ◽

pp. 17-23 ◽

Cited By ~ 9

Author(s):

Penghui Yang ◽

Chong Tang ◽

Deyan Luo ◽

Zhongpeng Zhan ◽

Li Xing ◽

...

Keyword(s):

Influenza Virus ◽

Influenza Vaccine ◽

H5n1 Influenza Virus ◽

Virus Challenge ◽

H5n1 Influenza ◽

Hpai H5n1

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Characterization of cross protection of Swine-Origin Influenza Virus (S-OIV) H1N1 and reassortant H5N1 influenza vaccine in BALB/c mice given a single-dose vaccination

Journal of Biomedical Science ◽

10.1186/1423-0127-20-19 ◽

2013 ◽

Vol 20 (1) ◽

pp. 19 ◽

Cited By ~ 1

Author(s):

Hui-Tsu Lin ◽

Chuan-Chang Chuang ◽

Hsieh-Ling Wu ◽

Der-Ming Chu ◽

Yeau-Ching Wang

Keyword(s):

Influenza Virus ◽

Single Dose ◽

Influenza Vaccine ◽

Cross Protection ◽

H5n1 Influenza

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Immunogenicity of a 2009 pandemic influenza virus A H1N1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy

Pediatric Blood & Cancer ◽

10.1002/pbc.24893 ◽

2014 ◽

Vol 61 (6) ◽

pp. 1013-1016 ◽

Cited By ~ 7

Author(s):

Gábor Ottóffy ◽

Petra Horváth ◽

Lajos Muth ◽

Alexander Sólyom ◽

Miklós Garami ◽

...

Keyword(s):

Influenza Virus ◽

Influenza Vaccine ◽

Pandemic Influenza ◽

Seasonal Influenza ◽

H1n1 Vaccine ◽

Seasonal Influenza Vaccine ◽

Influenza Virus A

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Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015–2016: a hospital-based test-negative case–control study in Lithuania

BMJ Open ◽

10.1136/bmjopen-2017-017835 ◽

2017 ◽

Vol 7 (10) ◽

pp. e017835 ◽

Cited By ~ 2

Author(s):

Monika Kuliese ◽

Ligita Jancoriene ◽

Rita Grimalauskaite ◽

Birute Zablockiene ◽

Gyte Damuleviciene ◽

...

Keyword(s):

Influenza Virus ◽

Influenza Vaccine ◽

Influenza A ◽

Seasonal Influenza ◽

Case Control Study ◽

Case Control ◽

Vaccine Effectiveness ◽

Seasonal Influenza Vaccine ◽

Influenza A H1n1 ◽

Control Study

ObjectiveA case–control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015–2016 influenza season.MethodsA study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR) .ResultsNinety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65 years old. Of the 72 (44.2%) influenza virus positive cases, 65 (39.9%) were confirmed with influenza A (including 50 cases of influenza A(H1N1)pdm09), eight (4.9%) were confirmed with influenza B and one was a co-infection. Unadjusted SIVE against any influenza, influenza type A and influenza A(H1N1)pdm09 was 57% (95% CI −41% to 87%), 52% (95% CI −57% to 85%) and 70% (95% CI −43% to 94%) respectively.ConclusionAlthough SIVE estimates were not statistically significant the point estimates suggest moderate effectiveness against influenza type A.

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