Human and Simian Immunodeficiency Virus Capsid Proteins Are Major Viral Determinants of Early, Postentry Replication Blocks in Simian Cells
2003 ◽
Vol 77
(1)
◽
pp. 726-731
◽
Keyword(s):
ABSTRACT The cells of most Old World monkey species exhibit early, postentry restrictions on infection by human immunodeficiency virus type 1 (HIV-1) but not by simian immunodeficiency virus of macaques (SIVmac). Conversely, SIVmac, but not HIV-1, infection is blocked in most New World monkey cells. By using chimeric HIV-1/SIVmac viruses capable of a single round of infection, we demonstrated that a major viral determinant of this restriction is the capsid (CA) protein. The efficiency of early events following HIV-1 and SIVmac entry is apparently determined by the interaction of the incoming viral CA and species-specific host factors.
Keyword(s):
1988 ◽
Vol 32
(11)
◽
pp. 1733-1734
◽
2001 ◽
Vol 356
(1410)
◽
pp. 815-823
◽
2003 ◽
Vol 77
(15)
◽
pp. 8237-8248
◽
2003 ◽
Vol 77
(2)
◽
pp. 1163-1174
◽
2003 ◽
Vol 77
(17)
◽
pp. 9295-9304
◽
2004 ◽
Vol 48
(9)
◽
pp. 3483-3490
◽