scholarly journals The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.

1990 ◽  
Vol 10 (8) ◽  
pp. 4016-4026 ◽  
Author(s):  
M von Lindern ◽  
A Poustka ◽  
H Lerach ◽  
G Grosveld
Keyword(s):  
Long Range ◽  
Cdna Cloning ◽  
Target Gene ◽  
Chromosomal Translocation ◽  
Chromosome Translocation ◽  
Chromosome 9 ◽  
Chromosome 6 ◽  
Acute Nonlymphocytic Leukemia ◽  
Chromosome Walking ◽  
Chromosome Isolation

The specific (6;9)(p23;q34) chromosomal translocation is associated with a defined subtype of acute nonlymphocytic leukemia (ANLL). The 9q34 breakpoint is located at the telomeric side of the c-abl gene. Through a combination of chromosome jumping, long-range mapping, and chromosome walking, the chromosome 9 breakpoints of several t(6;9) ANLL patients were localized within a defined region of 8 kilobases (kb), 360 kb telomeric of c-abl. Subsequent cDNA cloning revealed that this region represented an intron in the middle of a gene, called Cain (can), encoding a 7.5-kb transcript. Disruption of the can gene by the translocation resulted in the expression of a new 5.5-kb can mRNA from the 6p- chromosome. Isolation of chromosome 6 sequences showed that breakpoints on 6p23 also clustered within a limited stretch of DNA. These data strongly suggest a direct involvement of the translocation in the leukemic process of t(6;9) ANLL.

The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34

1990 ◽  
Vol 10 (8) ◽  
pp. 4016-4026
Author(s):  
M von Lindern ◽  
A Poustka ◽  
H Lerach ◽  
G Grosveld
Keyword(s):  
Long Range ◽  
Cdna Cloning ◽  
Target Gene ◽  
Chromosomal Translocation ◽  
Chromosome Translocation ◽  
Chromosome 9 ◽  
Chromosome 6 ◽  
Acute Nonlymphocytic Leukemia ◽  
Chromosome Walking ◽  
Chromosome Isolation

The specific (6;9)(p23;q34) chromosomal translocation is associated with a defined subtype of acute nonlymphocytic leukemia (ANLL). The 9q34 breakpoint is located at the telomeric side of the c-abl gene. Through a combination of chromosome jumping, long-range mapping, and chromosome walking, the chromosome 9 breakpoints of several t(6;9) ANLL patients were localized within a defined region of 8 kilobases (kb), 360 kb telomeric of c-abl. Subsequent cDNA cloning revealed that this region represented an intron in the middle of a gene, called Cain (can), encoding a 7.5-kb transcript. Disruption of the can gene by the translocation resulted in the expression of a new 5.5-kb can mRNA from the 6p- chromosome. Isolation of chromosome 6 sequences showed that breakpoints on 6p23 also clustered within a limited stretch of DNA. These data strongly suggest a direct involvement of the translocation in the leukemic process of t(6;9) ANLL.

Transmission of a wheat alien chromosome translocation with resistance to the wheat curl mite in common wheat, Triticum aestivum L.

1986 ◽  
Vol 28 (2) ◽  
pp. 294-297 ◽  
Author(s):  
E. D. P. Whelan ◽  
R. L. Conner ◽  
J. B. Thomas ◽  
A. D. Kuzyk
Keyword(s):  
Triticum Aestivum ◽  
Common Wheat ◽  
Triticum Aestivum L ◽  
Chromosome Translocation ◽  
Chromosome 6 ◽  
Selfed Progeny ◽  
Wheat Curl Mite ◽  
Aceria Tulipae ◽  
Group 6 ◽  
Homozygous Resistant

A translocation between a common wheat (Triticum aestivum L.) chromosome and chromosome 6 of Elytrigia pontica (Podp.) Holub conferred resistance to feeding by Eriophyes (= Aceria) tulipae Keifer, the mite vector of wheat streak mosaic virus and the wheat spot mosaic agent. Resistance was dominant, but differential transmission occurred between the pollen and the egg. Transmission of resistance through the pollen was low, about 3% in 'Cadet', 'Rescue', and 'Winalta', but significantly higher in 'Norstar' (9.1%). Significant differences also were detected in transmission through the egg. 'Cadet' had the highest transmission (50.9%) and 'Rescue' the lowest (40.5%). However, there were no significant differences among varieties in the frequencies of resistance (50.3–54.5%) in the F2. Less than 10% of the F2 plants were homozygous resistant. Selfed progeny from monosomic or disomic F1 plants from crosses between the homozygous translocation and group-6 monosomics all segregated for susceptibility. Meiotic studies of 25 susceptible F2 plants from these F1 monosomics showed that 21 were either monosomic or disomic and only 4 were nullisomic, indicating that the translocation did not involve any of the group-6 homoeologues. The translocation is considered to be a noncompensating translocation involving a whole arm of chromosome 6 of E. pontica.Key words: wheat, mite (wheat curl), translocation, Triticum.

From Long Range Mapping to Sequence-Ready Contigs on Human Chromosome 6

DNA Sequence ◽  
1997 ◽  
Vol 8 (3) ◽  
pp. 151-154 ◽  
Author(s):  
A. J. Mungall ◽  
S. J. Humphray ◽  
S. A. Ranby ◽  
C. A. Edwards ◽  
R. W. Heathcott ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Long Range ◽  
Chromosome 6 ◽  
Human Chromosome 6

The mouse α1(XII) and human α1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6

Genomics ◽  
1992 ◽  
Vol 14 (2) ◽  
pp. 225-231 ◽  
Author(s):  
Suk P. Oh ◽  
Reginald W. Taylor ◽  
Donald R. Gerecke ◽  
Julie M. Rochelle ◽  
Michael F. Seldin ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 9 ◽  
Chromosome 6 ◽  
Human Chromosome 6 ◽  
Collagen Genes

Long-range physical maps of two loci (Aps-1 and GP79) flanking the root-knot nematode resistance gene (Mi) near the centromere of tomato chromosome 6

1993 ◽  
Vol 23 (1) ◽  
pp. 185-192 ◽  
Author(s):  
Raymond A. J. J. van Daelen ◽  
Frans Gerbens ◽  
Fred van Ruissen ◽  
Jac Aarts ◽  
Jan Hontelez ◽  
...  
Keyword(s):  
Resistance Gene ◽  
Long Range ◽  
Nematode Resistance ◽  
Chromosome 6 ◽  
Root Knot Nematode ◽  
Physical Maps ◽  
Nematode Resistance Gene ◽  
Tomato Chromosome

scholarly journals Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia

Blood ◽  
1986 ◽  
Vol 68 (3) ◽  
pp. 652-657 ◽  
Author(s):  
R Bernstein ◽  
A Bagg ◽  
M Pinto ◽  
D Lewis ◽  
B Mendelow
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Chromosome Translocation ◽  
Chromosome 9 ◽  
Chromosome 3 ◽  
Acute Megakaryoblastic Leukemia ◽  
Blastic Transformation ◽  
Megakaryoblastic Leukemia ◽  
Platelet Counts

Abstract Two patients with acute blastic transformation of chronic myeloid leukemia (CML) associated with strikingly elevated platelet counts showed abnormalities of chromosome 3q in addition to the standard Philadelphia (Ph1) chromosome translocation. The first patient had an inversion of chromosome 3 (q21q26) cytologically identical to an inversion 3 previously reported in de novo acute megakaryoblastic leukemia, and the second patient showed a translocation between chromosome 3q and the chromosome 9 homologue not involved in the Ph1 translocation, [t(3;9)(q21;q34)]. Previous studies had incriminated either 3q21 or 3q26 as the locus for a regulatory thrombopoietic gene, but the current study suggests that 3q21 is the relevant site.

scholarly journals Integrative analysis of genomic, functional and protein interaction data predicts long-range enhancer-target gene interactions

2010 ◽  
Vol 39 (7) ◽  
pp. 2492-2502 ◽  
Author(s):  
Christian Rödelsperger ◽  
Gao Guo ◽  
Mateusz Kolanczyk ◽  
Angelika Pletschacher ◽  
Sebastian Köhler ◽  
...  
Keyword(s):  
Long Range ◽  
Protein Interaction ◽  
Target Gene ◽  
Integrative Analysis ◽  
Gene Interactions ◽  
Protein Interaction Data ◽  
Interaction Data

scholarly journals Pollen tube guidance by the female gametophyte

Development ◽  
1997 ◽  
Vol 124 (12) ◽  
pp. 2489-2498 ◽  
Author(s):  
S.M. Ray ◽  
S.S. Park ◽  
A. Ray
Keyword(s):  
Pollen Tube ◽  
Long Range ◽  
Female Gametophyte ◽  
Chromosomal Translocation ◽  
Pollen Grains ◽  
Pollen Tubes ◽  
Flowering Plants ◽  
Genetic Studies ◽  
Transmitting Tract ◽  
Pollen Tube Guidance

In flowering plants, pollen grains germinate on the pistil and send pollen tubes down the transmitting tract toward ovules. Previous genetic studies suggested that the ovule is responsible for long-range pollen tube guidance during the last phase of a pollen tube's journey to the female gametes. It was not possible, however, to unambiguously identify the signaling cells within an ovule: the haploid female gametophyte or the diploid sporophytic cells. In an effort to distinguish genetically between these two possibilities, we have used a reciprocal chromosomal translocation to generate flowers wherein approximately half the ovules do not contain a functional female gametophyte but all ovules contain genotypically normal sporophytic cells. In these flowers, pollen tubes are guided to the normal but not to the abnormal female gametophytes. These results strongly suggest that the female gametophyte is responsible for pollen tube guidance, but leave open the possibility that the gametophyte may accomplish this indirectly through its influence on some sporophytic cells.

THE PH1-CHROMOSOME: TRANSLOCATION TO CHROMOSOME 9

The Lancet ◽  
1973 ◽  
Vol 302 (7836) ◽  
pp. 1030-1031 ◽  
Author(s):  
H. Van Den Berghe
Keyword(s):  
Chromosome Translocation ◽  
Chromosome 9
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