scholarly journals Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

1998 ◽  
Vol 18 (2) ◽  
pp. 732-741 ◽  
Author(s):  
Kim M. Lonergan ◽  
Othon Iliopoulos ◽  
Michael Ohh ◽  
Takumi Kamura ◽  
Ronald C. Conaway ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
Human Homolog ◽  
Von Hippel Lindau ◽  
Specific Proteins ◽  
Apparent Similarity

ABSTRACT The von Hippel-Lindau tumor suppressor protein (pVHL) binds to elongins B and C and posttranscriptionally regulates the accumulation of hypoxia-inducible mRNAs under normoxic (21% O2) conditions. Here we report that pVHL binds, via elongin C, to the human homolog of the Caenorhabditis elegans Cul2 protein. Coimmunoprecipitation and chromatographic copurification data suggest that pVHL-Cul2 complexes exist in native cells. pVHL mutants that were unable to bind to complexes containing elongin C and Cul2 were likewise unable to inhibit the accumulation of hypoxia-inducible mRNAs. A model for the regulation of hypoxia-inducible mRNAs by pVHL is presented based on the apparent similarity of elongin C and Cul2 to Skp1 and Cdc53, respectively. These latter proteins form complexes that target specific proteins for ubiquitin-dependent proteolysis.

scholarly journals Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Hisashi Hasegawa ◽  
Yoshiaki Kusumi ◽  
Takeshi Asakawa ◽  
Miyoko Maeda ◽  
Toshinori Oinuma ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tongue Cancer ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau ◽  
Tongue Epithelium

scholarly journals von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms

2006 ◽  
Vol 66 (3) ◽  
pp. 1553-1560 ◽  
Author(s):  
Maria J. Calzada ◽  
Miguel A. Esteban ◽  
Monica Feijoo-Cuaresma ◽  
Maria C. Castellanos ◽  
Salvador Naranjo-Suárez ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Hypoxia Inducible Factor ◽  
Intercellular Junctions ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau

244 Kidney cancer and the von Hippel-Lindau tumor suppressor protein: implications for therapy

2004 ◽  
Vol 2 (8) ◽  
pp. 76
Author(s):  
W.G. Kaelin ◽  
W. Kim ◽  
S. Lee ◽  
A. Reddy ◽  
M. Safran ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Kidney Cancer ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau

scholarly journals Double-trouble in mitosis caused by von Hippel-Lindau tumor-suppressor protein inactivation

Cell Cycle ◽  
2009 ◽  
Vol 8 (22) ◽  
pp. 3619-3620 ◽  
Author(s):  
Claudio R. Thoma ◽  
Alberto Toso ◽  
Patrick Meraldi ◽  
Wilhelm Krek
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
Von Hippel Lindau ◽  
Protein Inactivation
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