Repression of insulin gene expression by adenovirus type 5 E1a proteins
1987 ◽
Vol 7
(3)
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pp. 1164-1170
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Keyword(s):
Insulin gene transcription relies on enhancer and promoter elements which are active in pancreatic beta cells. We showed that adenovirus type 5 infection of HIT T-15 cells, a transformed hamster beta cell line, represses insulin gene transcription and mRNA levels. Using expression plasmids transiently introduced into HIT T-15 cells, we showed that adenovirus type 5 E1a transcription regulatory proteins repress insulin enhancer-promoter element activity as assayed with a surrogate xanthine-guanine phosphoribosyltransferase gene. We relate E1a repression of the insulin gene to other examples of repression of enhancer-dependent genes by E1a and discuss the possible relationship of this repression to insulin gene regulation.
1987 ◽
Vol 7
(3)
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pp. 1164-1170
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Keyword(s):
1994 ◽
Vol 14
(1)
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pp. 655-662
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1989 ◽
Vol 9
(10)
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pp. 4531-4534
1989 ◽
Vol 9
(10)
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pp. 4531-4534
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2019 ◽
Vol 55
(4)
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pp. 226-236
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Keyword(s):
1991 ◽
Vol 266
(17)
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pp. 11141-11143
Keyword(s):
Keyword(s):
2005 ◽
Vol 280
(12)
◽
pp. 11887-11894
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