Telomerase inhibitors as novel antitumor drugs

2011 ◽  
Vol 47 (7) ◽  
pp. 655-660 ◽  
Author(s):  
A. I. Glukhov ◽  
L. V. Svinareva ◽  
S. E. Severin ◽  
V. I. Shvets
Keyword(s):  
Antitumor Drugs ◽  
Telomerase Inhibitors

EXPERIMENTAL STUDY OF THE EFFICACY OF L-LYSINE-A-OXIDASE TRICHODERMA CF. AUREOVIRIDE RIFAI ON MODELS OF XENOGRAFTS OF HUMAN TUMORS IN ATHYMIC MICE AND EVALUATION OF SYNERGISM WITH CISPLATIN OR TOPOISOMERASE INHIBITORS

2017 ◽  
Vol 63 (3) ◽  
pp. 497-505
Author(s):  
Vadim Pokrovskiy ◽  
Yelena Lukasheva ◽  
Nikolay Chernov ◽  
Yelena Treshchalina
Keyword(s):  
Experimental Study ◽  
Life Expectancy ◽  
Therapeutic Benefit ◽  
Human Tumors ◽  
Lymphocytic Leukemia ◽  
Antitumor Drugs ◽  
Athymic Mice ◽  
Lewis Lung ◽  
Topoisomerase Inhibitors ◽  
Inhibition Of Growth

The effectiveness of L-lysine-alpha oxidase Trichoderma cf. Aureoviride Rifai BKMF-4268D (LO) on models of subcutaneous xenografts of human tumors in athymic mice as well as the effectiveness of combination therapy with known antitumor drugs: cisplatin, irinotecan, etoposide on models of P388 lymphocytic leukemia, Lewis lung (LLC) and B16 melanoma was evaluated. The intraperitoneal injection of LO in a discrete regime at doses of 150-75-75-75-75 E/kg demonstrated inhibition of growth of all studied xenografts of human tumors in athymic mice. The combination of irinotecan+LO on the LLC model gave a significant summative therapeutic benefit with an increase in mouse life expectancy up to 35%. Cisplatin and LO realized a significant (p

The Targeted-liposome Delivery System of Antitumor Drugs

2015 ◽  
Vol 16 (10) ◽  
pp. 894-910 ◽  
Author(s):  
Wei-dang Wu ◽  
Xiu-lin Yi ◽  
Li-xin Jiang ◽  
Ya-zhuo Li ◽  
Jing Gao ◽  
...  
Keyword(s):  
Delivery System ◽  
Antitumor Drugs

KiSS1 in regulation of metastasis and response to antitumor drugs

2019 ◽  
Vol 42 ◽  
pp. 12-21 ◽  
Author(s):  
Cristina Corno ◽  
Paola Perego
Keyword(s):  
Antitumor Drugs

Telomerase Inhibitors: Potential Anticancer Agents

2016 ◽  
Vol 13 (1) ◽  
pp. 49-61 ◽  
Author(s):  
Rakesh R. Somani ◽  
Mayuri H. Patel
Keyword(s):  
Anticancer Agents ◽  
Telomerase Inhibitors

scholarly journals Design and study of telomerase inhibitors based on G-quadruplex ligands

2013 ◽  
Vol 29 (3) ◽  
pp. 169-176 ◽  
Author(s):  
V. V. Negrutska ◽  
L. V. Dubey ◽  
M. M. Ilchenko ◽  
I. Ya. Dubey
Keyword(s):  
Telomerase Inhibitors ◽  
G Quadruplex

scholarly journals Drug interaction of antitumor drugs. III. Antitumor activity of tegafur in lipopolysaccharide-treated mice.

1982 ◽  
Vol 32 (6) ◽  
pp. 1135-1142 ◽  
Author(s):  
Ken-ichi SASAKI ◽  
Shinobu FURUSAWA ◽  
Giichi TAKAYANAGI
Keyword(s):  
Drug Interaction ◽  
Antitumor Activity ◽  
Antitumor Drugs
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