KiSS1 in regulation of metastasis and response to antitumor drugs

2019 ◽  
Vol 42 ◽  
pp. 12-21 ◽  
Author(s):  
Cristina Corno ◽  
Paola Perego
Keyword(s):  
Antitumor Drugs

EXPERIMENTAL STUDY OF THE EFFICACY OF L-LYSINE-A-OXIDASE TRICHODERMA CF. AUREOVIRIDE RIFAI ON MODELS OF XENOGRAFTS OF HUMAN TUMORS IN ATHYMIC MICE AND EVALUATION OF SYNERGISM WITH CISPLATIN OR TOPOISOMERASE INHIBITORS

2017 ◽  
Vol 63 (3) ◽  
pp. 497-505
Author(s):  
Vadim Pokrovskiy ◽  
Yelena Lukasheva ◽  
Nikolay Chernov ◽  
Yelena Treshchalina
Keyword(s):  
Experimental Study ◽  
Life Expectancy ◽  
Therapeutic Benefit ◽  
Human Tumors ◽  
Lymphocytic Leukemia ◽  
Antitumor Drugs ◽  
Athymic Mice ◽  
Lewis Lung ◽  
Topoisomerase Inhibitors ◽  
Inhibition Of Growth

The effectiveness of L-lysine-alpha oxidase Trichoderma cf. Aureoviride Rifai BKMF-4268D (LO) on models of subcutaneous xenografts of human tumors in athymic mice as well as the effectiveness of combination therapy with known antitumor drugs: cisplatin, irinotecan, etoposide on models of P388 lymphocytic leukemia, Lewis lung (LLC) and B16 melanoma was evaluated. The intraperitoneal injection of LO in a discrete regime at doses of 150-75-75-75-75 E/kg demonstrated inhibition of growth of all studied xenografts of human tumors in athymic mice. The combination of irinotecan+LO on the LLC model gave a significant summative therapeutic benefit with an increase in mouse life expectancy up to 35%. Cisplatin and LO realized a significant (p

The Targeted-liposome Delivery System of Antitumor Drugs

2015 ◽  
Vol 16 (10) ◽  
pp. 894-910 ◽  
Author(s):  
Wei-dang Wu ◽  
Xiu-lin Yi ◽  
Li-xin Jiang ◽  
Ya-zhuo Li ◽  
Jing Gao ◽  
...  
Keyword(s):  
Delivery System ◽  
Antitumor Drugs

scholarly journals Drug interaction of antitumor drugs. III. Antitumor activity of tegafur in lipopolysaccharide-treated mice.

1982 ◽  
Vol 32 (6) ◽  
pp. 1135-1142 ◽  
Author(s):  
Ken-ichi SASAKI ◽  
Shinobu FURUSAWA ◽  
Giichi TAKAYANAGI
Keyword(s):  
Drug Interaction ◽  
Antitumor Activity ◽  
Antitumor Drugs

Induction of Apoptosis by Hybrid Liposomes without Antitumor Drugs toward Human Breast Tumor Cells

2003 ◽  
Vol 36 (9) ◽  
pp. 1127-1129 ◽  
Author(s):  
Hideaki Nagami ◽  
Keiichi Yamamoto ◽  
Hideaki Ichihara ◽  
Yoko Matsumoto ◽  
Ryuichi Ueoka
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Antitumor Drugs ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Breast Tumor Cells ◽  
Induction Of Apoptosis

Human Hepatocellular Carcinoma Sensitivity to Antitumor Drugs Assayed Using the Succinate Dehydrogenase Inhibition Test

Oncology ◽  
1991 ◽  
Vol 48 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Takashi Kanematsu ◽  
Yoshihiko Maehara ◽  
Takashi Matsumata ◽  
Ken Shirabe ◽  
Kouhei Akazawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Succinate Dehydrogenase ◽  
Inhibition Test ◽  
Human Hepatocellular Carcinoma ◽  
Antitumor Drugs

scholarly journals Electrochemical DNA Sensor Based on Carbon Black—Poly(Neutral Red) Composite for Detection of Oxidative DNA Damage

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3489 ◽  
Author(s):  
Yurii Kuzin ◽  
Dominika Kappo ◽  
Anna Porfireva ◽  
Dmitry Shurpik ◽  
Ivan Stoikov ◽  
...  
Keyword(s):  
Carbon Black ◽  
Oxidative Dna Damage ◽  
Electrochemical Impedance ◽  
Neutral Red ◽  
Redox Activity ◽  
Antitumor Drugs ◽  
Oxygen Species ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor ◽  
Polymeric Dye

Voltammetric DNA sensor has been proposed on the platform of glassy carbon electrode covered with carbon black with adsorbed pillar[5]arene molecules. Electropolymerization of Neutral Red performed in the presence of native or oxidatively damaged DNA resulted in formation of hybrid material which activity depended on the DNA conditions. The assembling of the surface layer was confirmed by scanning electron microscopy and electrochemical impedance spectroscopy. The influence of DNA and pillar[5]arene on redox activity of polymeric dye was investigated and a significant increase of the peak currents was found for DNA damaged by reactive oxygen species generated by Cu2+/H2O2 mixture. Pillar[5]arene improves the electron exchange conditions and increases the response and its reproducibility. The applicability of the DNA sensor developed was shown on the example of ascorbic acid as antioxidant. It decreases the current in the concentration range from 1.0 μM to 1.0 mM. The possibility to detect antioxidant activity was qualitatively confirmed by testing tera infusion. The DNA sensor developed can find application in testing of carcinogenic species and searching for new antitumor drugs.

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