Event-Related Desynchronization/Synchronization of Electrical Brain Activity during Modified Odd-Ball Tasks in Patients with Coronary Artery Disease and Mild Cognitive Impairment

Introduction: Recent studies have shown that Polyunsaturated Fatty Acids (PUFAs), including Eicosapentaenoic Acid (EPA), and Arachidonic Acid (AA), are associated with cognitive functions in patients with Coronary Artery Disease (CAD). Nevertheless, controversial results have been reported, too. The current study aimed to clarify the association of serum EPA and AA levels with cognitive decline in an Iranian sample with CAD. Methods: We evaluated cognitive function with the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), in relation to serum levels of EPA and AA, in 179 CAD patients. The associations between the MMSE and MoCA scores and the other demographic parameters were evaluated. Results: Patients with CAD generally had mild cognitive impairment. But we could not find any significant correlation between PUFAs and cognitive function. However, BMI was associated with EPA/MoCA; age was associated with MMSE/MoCA and BMI. Finally, the correlation between sex and MMSE/MoCA was significant. Conclusion: Subjects generally had mild cognitive impairment, but we could not find any significant correlation between serum EPA and AA levels with cognitive function.

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Lipid Peroxidation Markers in Coronary Artery Disease Patients with Possible Vascular Mild Cognitive Impairment

Journal of Alzheimer s Disease ◽

10.3233/jad-161248 ◽

2017 ◽

Vol 58 (3) ◽

pp. 885-896 ◽

Cited By ~ 5

Author(s):

Ivonne Suridjan ◽

Nathan Herrmann ◽

Alex Adibfar ◽

Mahwesh Saleem ◽

Ana Andreazza ◽

...

Keyword(s):

Coronary Artery Disease ◽

Lipid Peroxidation ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Coronary Artery ◽

Artery Disease

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Gait speed, life-space mobility and mild cognitive impairment in patients with coronary artery disease

Heart and Vessels ◽

10.1007/s00380-020-01677-y ◽

2020 ◽

Author(s):

Kodai Ishihara ◽

Kazuhiro P. Izawa ◽

Masahiro Kitamura ◽

Masato Ogawa ◽

Takayuki Shimogai ◽

...

Keyword(s):

Coronary Artery Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Coronary Artery ◽

Gait Speed ◽

Life Space ◽

Artery Disease

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Serum concentration of dihomo-γ-linolenic acid is associated with cognitive function and mild cognitive impairment in coronary artery disease patients

Prostaglandins Leukotrienes and Essential Fatty Acids ◽

10.1016/j.plefa.2019.102038 ◽

2020 ◽

Vol 158 ◽

pp. 102038 ◽

Cited By ~ 1

Author(s):

Kodai Ishihara ◽

Kazuhiro P. Izawa ◽

Masahiro Kitamura ◽

Takayuki Shimogai ◽

Yuji Kanejima ◽

...

Keyword(s):

Coronary Artery Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Coronary Artery ◽

Cognitive Function ◽

Serum Concentration ◽

Linolenic Acid ◽

Artery Disease

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EEG and Clinical Factors Associated with Mild Cognitive Impairment in Coronary Artery Disease Patients

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000493787 ◽

2018 ◽

Vol 46 (5-6) ◽

pp. 275-284 ◽

Cited By ~ 2

Author(s):

Irina V. Tarasova ◽

Olga A. Trubnikova ◽

Olga L. Barbarash

Keyword(s):

Coronary Artery Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Coronary Artery ◽

Right Hemisphere ◽

Cognitive Status ◽

Syntax Score ◽

Activity Increase ◽

Increased Risk ◽

Artery Disease

Background: Although an impaired cognitive status in patients with coronary artery disease (CAD) is not rare, the neurophysiological and clinical indicators of mild cognitive impairment (MCI) have been insufficiently investigated so far. Methods: EEG and neuropsychological testing as well as clinical examination were performed on 122 patients with CAD, who were divided into two groups, those with MCI (n = 60; mean age 57.4 ± 5.81 years) and those without MCI (n = 62; mean age 57.0 ± 5.04 years). Binary logistic regression was used to identify the relationship between EEG and clinical variables and the probability of MCI. Results: Higher theta/alpha ratios, theta1 rhythm power with closed eyes in the frontal and occipital areas of the left hemisphere, and alpha2 rhythm power with eyes open in the frontal areas of the right hemisphere were associated with an increased risk for MCI in CAD patients. A low educational level, type 2 diabetes mellitus, and severe coronary lesions according to the SYNTAX Score (≥23 points) increased the risk for MCI as well. Conclusions: The findings of our study show that a theta activity increase in frontal and occipital sites, as well as high theta/alpha ratios, may be considered as the earliest EEG markers of vascular cognitive disorders.

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