The 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2,4-dihydroxyacetophenone undergo condensation to afford (E)3-2-(1-(2,4-dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff base (DHPEAPMQ). The newly synthesized Schiff base (DHPEAPMQ) and its metal complexes were evaluated for their antimicrobial activity against methicillin-resistantStaphylococcus aureusisolated from the Gulbarga region in India. The Cu(II), Ni(II), and Zn(II) complexes of Schiff base (DHPEAPMQ) showed good antimicrobial activity. So, this could be a new drug of choice.
An area of great interest in recent years has been chalcones. Chalcones are the important component
of many natural sources and have variety of biological activities. Chalcones which are also known as α,βunsaturated ketones is an significant class of organic compounds and reported to possess a wide spectrum of
biological activities such as antibacterial, antifungal, anticancer, anti-inflammatory etc. Abundant research papers
have been published and chalcones continue to show promise for new drug investigations. The derivative of
chalcones were prepared using Claisen–Schmidt condensation scheme. The structure of the synthesized was
confirmed by UV and IR. The compound was also tested for their antimicrobial activity
(E)3-2-(1-(2,4-Dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff Base and Its Metal Complexes: A New Drug of Choice against Methicillin-ResistantStaphylococcus aureus