Altered thyroid hormone production induced by long-term exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane

Changes in secretion of thyroid autoantigenes and production of antithyroid autoantibodies after long-term exposure to low doses of DDT were studied. Changes in serum levels of antithyroid peroxidase antibodies and thyroid peroxidase, attributed to disruption of thyroxine production by DDT were found. Long-term exposure of rats to low doses of DDT revealed no specific impact on serum autoantibodies to all thyroid autoantigenes studied. The increase of the ratio of autoantibody/autoantigen for thyroid peroxidase and thyroglobulin was rather small and thus could not be considered as a significant symptom of thyroid autoimmunity.

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Alteration of thyroid hormone secretion after long-term exposure to low doses of endocrine disruptor DDT

Biomeditsinskaya Khimiya ◽

10.18097/pbmc20146006655 ◽

2014 ◽

Vol 60 (6) ◽

pp. 655-660 ◽

Cited By ~ 3

Author(s):

N.V. Yaglova ◽

V.V. Yaglov

Keyword(s):

Thyroid Hormone ◽

Hormone Secretion ◽

Thyroid Peroxidase ◽

Low Doses ◽

Male Wistar Rats ◽

Total Thyroxine ◽

Dose Dependent Increase ◽

Dose Dependent ◽

Exogenous Substances

Endocrine disruptors are exogenous substances that exhibit hormone-like action and consequently disrupt homeostatic action of endogenous hormones. DDT is the most common disruptor. The objective was to evaluate changes in thyroid hormone secretion after long-term exposure to low doses of DDT. The experiment was performed on male Wistar rats. The rats were given DDT at doses of 1.89±0.86 мg/kg/day and 7.77±0.17 мg/kg/day for 6 and 10 weeks. Dose dependent increase of serum total thyroxine, total triiodthyronine, and thyroid peroxidase was revealed after 6 weeks exposure. After 10 weeks free thyroxine secretion was reduced. Such alterations of the thyroid status are typical for iodine deficient goiter. The data obtained indicate that the main mechanism of DDT action includes disruption of thyroxine secretion by thyrocytes, but not inhibition of deiodinase activity and decrease of blood thyroid binding proteins.

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MRNA differential display identification of thyroid hormone-responsive protein (THRP) gene in association with early phase of long-term potentiation

Hippocampus ◽

10.1002/hipo.1078 ◽

2001 ◽

Vol 11 (6) ◽

pp. 637-646 ◽

Cited By ~ 16

Author(s):

Y.P. Tang ◽

Y.L. Ma ◽

S.K. Chen ◽

E.H.Y. Lee

Keyword(s):

Thyroid Hormone ◽

Differential Display ◽

Early Phase ◽

Long Term Potentiation ◽

Mrna Differential Display ◽

Term Potentiation

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The Effect of Long-Term Metabolic Control on Free Thyroid Hormone Levels in Diabetics during Insulin Treatment

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456328702400507 ◽

1987 ◽

Vol 24 (5) ◽

pp. 466-469 ◽

Cited By ~ 2

Author(s):

J H Parr

Keyword(s):

Thyroid Hormone ◽

Metabolic Control ◽

Insulin Treatment ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Hormone Levels ◽

Free Thyroid Hormone ◽

The Mean ◽

Thyroid Hormone Levels

Serum concentration of free T3 and, in female patients, FT4, were found to be lower in 20 asymptomatic, moderately-poor or well controlled, diabetics treated with insulin than in a group of non-diabetic subjects. Over a mean 3-month period of the study a significant fall occurred in HbA1 concentration in both groups of diabetics without change in free thyroid hormone levels. The mean capillary blood glucose, fasting free insulin and fasting lipid concentrations, other than high density lipoprotein (HDL) cholesterol, did not change. No correlations were found between the changes in HbA1 and free thyroid hormone concentrations. Improvement in long term metabolic control did not influence free thyroid hormone levels in well controlled and moderately-poor controlled diabetics, taking insulin.

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