Synthesis and Antituberculotic Activity of Some Substituted 3-Arylamino-5-cyano-2-pyrazinecarboxamides
1995 ◽
Vol 60
(7)
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pp. 1236-1241
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Keyword(s):
Nucleophilic substitution of 3-chloro-5-cyano-2-pyrazinecarboxamide by substituted anilines afforded substituted 3-arylamino-5-cyano-2-pyrazinecarboxamides I-X. The structures of compounds were confirmed by elemental analysis, UV, IR and 1H NMR spectra. The assessment of in vitro antimycotic and antimycobacterial activities of the compounds was carried out. The highest antituberculotic activity against M. tuberculosis in this series was shown by 3-anilino- 5-cyano-2-pyrazinecarboxamide (I), whose efficacy was the same as that of pyrazinecarboxamide.
1996 ◽
Vol 61
(7)
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pp. 1109-1114
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1996 ◽
Vol 61
(7)
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pp. 1102-1108
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Keyword(s):
2017 ◽
Vol 9
(2)
◽
pp. 192
1971 ◽
Vol 26
(2)
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pp. 75-78
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