Solid-Phase Traceless Synthesis of Selected Nitrogen-Containing Heterocyclic Compounds. The Encore Technique for Directed Sorting of Modular Solid Support
2001 ◽
Vol 66
(7)
◽
pp. 1078-1106
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Keyword(s):
The acid lability of electron-rich N-benzylanilines has been exploited in a linker for the traceless solid-phase synthesis of benzimidazoles, 2-aminobenzimidazoles, quinoxalinones and tetrahydroquinoxalines. The target compound precursors were assembled on a solid-phase support derivatized with either a benzylamine or a benzhydrylamine linker. Exposure to an acidic reagent caused cleavage of the C(benzyl)-N(aniline) bond, releasing the product with only a hydrogen atom on the descending nitrogen. The Encore technique for directed sorting on SynPhase Lanterns has been developed and applied to combinatorial synthesis of generic drug discovery libraries.
2005 ◽
Vol 7
(6)
◽
pp. 977-986
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Keyword(s):
2003 ◽
Vol 17
(08n09)
◽
pp. 1910-1915
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2008 ◽
Vol 73
(1)
◽
pp. 32-43
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Keyword(s):
2000 ◽
Vol 2
(1)
◽
pp. 48-65
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2000 ◽
Vol 2
(4)
◽
pp. 378-381
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Keyword(s):
2000 ◽
Vol 41
(4)
◽
pp. 441-445
◽
Keyword(s):
Keyword(s):