SAT0163 Risk factors related to low heel bone mineral density in postmenopausal women

Background:Chronic inflammatory rheumatic diseases are risk factors of bone loss and fractures. Systemic sclerosis (SSc) has been recognized to be another potential inflammatory joint disease that may affect bone tissue.Objectives:to evaluate bone mineral density (BMD) and risk factors of low BMD in women with SSc.Methods:173 women, among them 110 postmenopausal (median age 60[55,63] years) and 63 premenopausal (median age 35[31,44] years). BMD was measured at lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry (DXA, Hologic 4500A). Low BMD was diagnosed if the T-score was < -1.0 standard deviation (SD) in postmenopausal women and if the Z-score was < -2.0 SD in premenopausal women. The relationship between BMD and SSc patients’ characteristics was evaluated using univariate linear regression analysis.Results:Low BMD was found in 66% patients: 79% - in postmenopausal and 18% - in premenopausal women. Among postmenopausal persons osteoporosis was discovered in 47% and osteopenia – in 32% cases. In postmenopausal woman BMD of LS, FN and TH were associated with body mass index (BMI) (β=0.27, p=0.010; β=0.47, p<0,001 and β=0.45, p<0,001, respectively), duration of glucocorticoids (GCs) using (β=-0.31, p=0.008; β=-0.34, p=0.003 and β=-0.27, p=0.022, respectively); BMD of FN and TH with C-reactive protein (β= -0.32, p=0.016 and β= -0.29, p=0.029, respectively) and LS BMD with current and cumulative GCs dose (β= -0.24, p=0.039 and β= -0.29, p=0.014, respectively). In premenopausal women BMD of LS, FN and TH were associated with BMI (β=0.51, p<0,001; β=0.45, p=0.003 and β=0.47, p=0.002, respectively), duration of GCs using (β= -0.45, p=0.004; β= -0.47, p=0.003 and β= -0.48, p=0.002, respectively) and GCs cumulative dose (β= -0.48, p=0.002; β= -0.51, p=0.001 and β= -0.46, p=0.004, respectively); BMD of FN and TH with 25(ОН)D level (β=0.52, p=0.008 and β=0.54, p=0.005, respectively), and LS BMD with SSc duration (β= -0.44, p=0.004).Conclusion:Low BMD was diagnosed in 66% of women with SSc. Low BMI, GCs cumulative dose and duration of GCs using were independent risk factors for low BMD in both premenopausal and postmenopausal persons. Additional factors as SSc duration and low vitamin D level were found out for premenopausal and current GCs dose and C-reactive protein level for postmenopausal women.Disclosure of Interests:None declared

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98 GROUND REACTION FORCES OF POSTMENOPAUSAL WOMEN: INFLUENCE OF HEEL BONE MINERAL DENSITY AND REGIONAL SOFT LEAN MASS

Maturitas ◽

10.1016/s0378-5122(12)70209-8 ◽

2012 ◽

Vol 71 ◽

pp. S51

Author(s):

M.H. Moreira ◽

R.E. Gabriel ◽

A. Leite ◽

F.R. Aragão ◽

J. Fonseca ◽

...

Keyword(s):

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Lean Mass ◽

Ground Reaction Forces ◽

Mineral Density ◽

Heel Bone ◽

Reaction Forces

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Prevalence and risk factors of low bone mineral density with quantitative ultrasonography among south Indian postmenopausal women

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20162034 ◽

2016 ◽

pp. 1735-1740 ◽

Cited By ~ 2

Author(s):

Sudha Bala ◽

M. Prabha ◽

T. Krishna

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density ◽

Quantitative Ultrasonography ◽

Low Bone Mineral Density ◽

South Indian

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Effects of Abaloparatide-SC on Fractures and Bone Mineral Density in Subgroups of Postmenopausal Women with Osteoporosis and Varying Baseline Risk Factors

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2017.10.024 ◽

2018 ◽

Vol 21 (1) ◽

pp. 28 ◽

Cited By ~ 1

Author(s):

F. Cosman ◽

G. Hattersley ◽

M.Y. Hu ◽

G.C. Williams ◽

L.A. Fitzpatrick ◽

...

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Baseline Risk ◽

Mineral Density

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Risk Management of Osteoporosis in Postmenopausal Women; A Study of Women In a Teaching Hospital

Global Journal of Health Science ◽

10.5539/gjhs.v8n11p36 ◽

2016 ◽

Vol 8 (11) ◽

pp. 36 ◽

Cited By ~ 1

Author(s):

Chander Kumar Lohana ◽

Nafisa Samir

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Public Awareness ◽

Clinical Manifestations ◽

Radiology Department ◽

Premature Menopause ◽

Mineral Density ◽

History Of

BACKGROUND: Postmenopausal females are susceptible to osteoporosis due to clinical manifestations. It not only causes morbidity; but, is considered to strikingly decline quality of life among patients. Among different developing regions, the prevalence rate of osteoporosis among postmenopausal women is alarming in the face of poor management and awareness about its risk factors.AIM: The aim of this study was to investigate the incidence of osteoporosis and its known risk factors among postmenopausal women appearing for bone mineral density in Karachi.METHODOLOGY: This descriptive cross-sectional study was undertaken from the period of “March 2006 to March 2007” in “Aga Khan University hospital”, Karachi. A total of 245 females, who came to the radiology department at Aga Khan Hospital for DXA scan, were recruited. All the relevant data was collected through questionnaires. Data analysis was undertaken by using SPSS version 11.5 to generate frequencies and proportion percentages.RESULTS: The study demonstrated that 99 females (40%) amongst all subjects were osteopenic, 114 females (47%) were osteoporotic; whereas, 32 females (13%) were normal. A decline was observed in bone mineral density with advancing age and duration of menopause. The distribution of osteoporosis was observed to be common in women, who had more children, low BMI, history of prior fractures, history of premature menopause, and were avoiding exercise.CONCLUSION: This study confirmed a high frequency of osteoporosis and osteopenia in postmenopausal women. Therefore, early screening is required to detect the decrease in bone mineral density among postmenopausal females to prevent fragility fracture. There is an imperative requirement for vast public awareness in this regard.

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Multifactorial analysis of risk factors for reduced bone mineral density among postmenopausal women

Archives of Medical Science ◽

10.5114/aoms.2012.28562 ◽

2012 ◽

Vol 2 ◽

pp. 332-341 ◽

Cited By ~ 6

Author(s):

Grażyna Bączyk ◽

Tomasz Opala ◽

Paweł Kleka ◽

Marek Chuchracki

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density ◽

Multifactorial Analysis

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Risk factors for low bone mineral density in postmenopausal women with systemic sclerosis

Rheumatology Science and Practice ◽

10.47360/1995-4484-2021-592-598 ◽

2021 ◽

Vol 59 (5) ◽

pp. 592-598

Author(s):

A. O. Efremova ◽

N. V. Toroptsova ◽

O. V. Dobrovolskaya ◽

M. N. Starovoitova ◽

O. V. Desinova ◽

...

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Systemic Sclerosis ◽

Postmenopausal Women ◽

Bone Mineral ◽

Cumulative Dose ◽

Linear Regression Analysis ◽

Exclusion Criterion ◽

Multivariate Linear Regression Analysis ◽

Mineral Density

Aim of the research – to determine the frequency of osteoporosis (OP) and to identify risk factors for a decrease in bone mineral density (BMD) in postmenopausal women with systemic sclerosis (SSс).Subjects and methods. The study included 113 postmenopausal women (median age – 60.0 [54.0; 63.0] years) with a reliable diagnosis of SSc according to the ACR/EULAR criteria (2013). The exclusion criterion was the presence of overlap syndromes. All women were interviewed according to a unified questionnaire, a laboratory and instrumental examination was conducted, including Dual-energy X-ray absorptiometry.Results. OP and osteopenia in at least one measurement area were diagnosed in 45.1% and 48.7% of women, respectively. Multivariate linear regression analysis revealed a negative effect of the total experience of taking glucocorticoids (GCs) on the value of BMD in the lumbar spine (b=–0.005; R2=0.136; p=0.017). Body mass index (BMI) (b=0.007; R2=0.208; p<0.001), glomerular filtration rate (GFR) (b=0.313; R2=0.213; p<0.001) is positive, and the cumulative dose of GCs (b=–0.269; R2=0.134; p<0.001), the duration of taking proton pump inhibitors (PPI) (b=–0.277; R2=0.291; p<0.001) and the duration of postmenopause (b=–0,223; R2=0.134; p<0.001) negatively affected the BMD of the femoral neck. BMD in the total hip (TH) was generally positively associated with BMI (b=0.493; R2=0.244; p<0.001), GFR (b=0.313; R2=0.150; p<0.001), 25-hydroxy calciferol level (b=0.273; R2=0.284; p=0.001), and negatively – with the cumulative dose of GCs (b=–0.219; R2=0.289; p<0.001).Conclusion. 93.8% of postmenopausal women with SSс had reduced BMD. Of the traditional risk factors, only BMI, the duration of postmenopause and the level of vitamin D had an impact on the state of BMD, and among the specific ones – the cumulative dose and duration of taking GCs, PPI and GFR.

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The effects of one-year simvastatin therapy on women’s bone mineral density

Open Medicine ◽

10.2478/s11536-010-1031-8 ◽

2010 ◽

Vol 5 (5) ◽

pp. 588-592 ◽

Cited By ~ 2

Author(s):

Aleksandar Dimic ◽

Dimitrije Jankovic ◽

Irena Jankovic ◽

Todorka Savic ◽

Nevena Karanovic

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Postmenopausal Women ◽

Bone Mineral ◽

Treated Group ◽

Mineral Density ◽

Simvastatin Therapy ◽

Group 2 ◽

One Year ◽

Group 1

AbstractOnly few studies have reported that bone fracture risk is decreased in hypercholesterolemic postmenopausal women treated with statin therapy. Because of a lack of longitudinal studies on the effect of statins on bones, the aim of our investigation was to estimate the simvastatin therapy effects on bone mineral density in hypercholesterolemic postmenopausal women. Our investigation was carried out on 53 postmenopausal women with hypercholesterolemia. The women included in the study were divided into two groups. Group 1 was comprised of women with two or more (n=32) atherosclerosis risk factors, whereas group 2 had women with less than two (n=21) of these risk factors. All the women included in the study were placed on a hypocholesterolemic diet and the women in group 1 were additionally treated with 20 mg of simvastatin daily. The parameters of lipid status, body mass index, and L2–L4 densitometry were determined at baseline and then after one year. The simvastatin-treated group showed significant improvement of lipid parameters and increased bone mineral density. Finally, changes in bone mineral density between the groups showed significant differences (p<0.05). Although our investigation was carried out on a small group, our results showed a positive effect of the simvastatin therapy on the bone mineral density of postmenopausal women.

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