FRI0347 Predictive factors of long-term clinical outcome in patients with ocular involvement secondary to behcet’s disease.

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A491.2-A491
Author(s):  
C. Ferrari ◽  
R. Talarico ◽  
C. Stagnaro ◽  
A. d’Ascanio ◽  
C. Tani ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Behçet’S Disease ◽  
Predictive Factors ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Ocular Involvement ◽  
Behcet's Disease

scholarly journals Old and New Challenges in Uveitis Associated with Behçet’s Disease

2021 ◽  
Vol 10 (11) ◽  
pp. 2318
Author(s):  
Julie Gueudry ◽  
Mathilde Leclercq ◽  
David Saadoun ◽  
Bahram Bodaghi
Keyword(s):  
Behçet’S Disease ◽  
Structural Damage ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Retinal Vasculitis ◽  
Unknown Origin ◽  
Current Data ◽  
Ocular Involvement ◽  
Behcet's Disease

Behçet’s disease (BD) is a systemic vasculitis disease of unknown origin occurring in young people, which can be venous, arterial or both, classically occlusive. Ocular involvement is particularly frequent and severe; vascular occlusion secondary to retinal vasculitis may lead to rapid and severe loss of vision. Biologics have transformed the management of intraocular inflammation. However, the diagnosis of BD is still a major challenge. In the absence of a reliable biological marker, diagnosis is based on clinical diagnostic criteria and may be delayed after the appearance of the onset sign. However, therapeutic management of BD needs to be introduced early in order to control inflammation, to preserve visual function and to limit irreversible structural damage. The aim of this review is to provide current data on how innovations in clinical evaluation, investigations and treatments were able to improve the prognosis of uveitis associated with BD.

Brief Report: Drug-Free Long-Term Remission in Severe Behçet's Disease Following Withdrawal of Successful Anti-Tumor Necrosis Factor Treatment

2017 ◽  
Vol 69 (12) ◽  
pp. 2380-2385 ◽  
Author(s):  
Petros P. Sfikakis ◽  
Aikaterini Arida ◽  
Stylianos Panopoulos ◽  
Kalliopi Fragiadaki ◽  
George Pentazos ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Behçet’S Disease ◽  
Tumor Necrosis ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Drug Free ◽  
Necrosis Factor ◽  
Tumor Necrosis Factor Treatment

scholarly journals MiR-146a and miR-155 polymorphisms in Egyptian patients with Behcet’s disease

2021 ◽  
Author(s):  
Omayma Abdelaleem ◽  
Olfat Shaker
Keyword(s):  
Risk Factor ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Recessive Model ◽  
Additive Models ◽  
Ocular Involvement ◽  
Behcet's Disease ◽  
Egyptian Population ◽  
Egyptian Patients

IntroductionBackground: The current study designed to analyze whether polymorphisms of miR-146a and miR-155 are related to Behçet’s disease (BD) in Egyptian population.Material and methodsMethods: A total of 96 unrelated BD patients and 100 healthy subjects were genotyped for miR-146a (rs2910164) and miR-155(rs767649) using real-time polymerase chain reaction.ResultsResults: the results showed significant elevation in the frequency of rs2910164 GG and CC genotypes in BD patients compared with controls (adjusted OR = 22.156, 95% CI (4.728-103.818); P < 0.001 and adjusted OR = 40.358, 95% CI (8.928 -182.440); P < 0.001, respectively). Also, rs2910164 G allele conferred a higher risk of developing BD (adjusted OR = 3.665, 95% CI (2.013-6.671); P < 0.001). MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance(All P < 0.001), while, the miR-155(rs767649) polymorphism was a risk factor in recessive model only (P = 0.021). GG and CG genotypes of rs2910164 were associated with higher BDCAI activity and ocular involvement compared with CC genotype (P = 0.005 and P =0.004, respectively). Genotype AT of rs767649 was related to higher BDCAI activity (P = 0. 026) compared with TT or AA genotypes.ConclusionsConclusion: The miR-146a (rs2910164) and miR-155(rs767649) were likely to play an important role in Egyptian population to develop BD and also influence disease severity.

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