SAT0484 Bsmi VDR Gene Polymorphism is Associated with Bone Mineral Density and Bone Metabolism in Established Rheumatoid Arthritis Patients

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 768.2-768
Author(s):  
M. Bernardes ◽  
J.C. Machado ◽  
T. Vieira ◽  
D. Gonçalves ◽  
R. Vieira ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Gene Polymorphism ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Established Rheumatoid Arthritis ◽  
Mineral Density ◽  
Vdr Gene ◽  
Vdr Gene Polymorphism

scholarly journals Vitamin D Status, Bone Mineral Density and VDR Gene Polymorphism in a Cohort of Belarusian Postmenopausal Women

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 837
Author(s):  
Pavel Marozik ◽  
Alena Rudenka ◽  
Katsiaryna Kobets ◽  
Ema Rudenka
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Dose Effect ◽  
Control Group ◽  
Gene Variants ◽  
Mineral Density ◽  
Vdr Gene ◽  
Vdr Gene Polymorphism

Vitamin D plays an important role in bone metabolism and is important for the prevention of multifactorial pathologies, including osteoporosis (OP). The biological action of vitamin is realized through its receptor, which is coded by the VDR gene. VDR gene polymorphism can influence individual predisposition to OP and response to vitamin D supplementation. The aim of this work was to reveal the effects of VDR gene ApaI rs7975232, BsmI rs1544410, TaqI rs731236, FokI rs2228570, and Cdx2 rs11568820 variants on bone mineral density (BMD), 25-hydroxyvitamin D level, and OP risk in Belarusian women. Methods. The case group included 355 women with postmenopausal OP, and the control group comprised 247 women who met the inclusion criteria. TaqMan genotyping assay was used to determine VDR gene variants. Results. Rs7975232 A/A, rs1544410 T/T, and rs731236 G/G single variants and their A-T-G haplotype showed a significant association with increased OP risk (for A-T-G, OR = 1.8, p = 0.0001) and decreased BMD (A-T-G, −0.09 g/cm2, p = 0.0001). The rs11568820 A-allele showed a protective effect on BMD (+0.22 g/cm2, p = 0.027). A significant dose effect with 25(OH)D was found for rs1544410, rs731236, and rs11568820 genotypes. Rs731236 A/A was associated with the 25(OH)D deficiency state. Conclusion. Our novel data on the relationship between VDR gene variants and BMD, 25(OH)D level, and OP risk highlights the importance of genetic markers for personalized medicine strategy.

scholarly journals Effect of VDR gene polymorphism on bone mineral density in puerperants

2018 ◽  
Vol 67 (5) ◽  
pp. 4-12
Author(s):  
Olga S. Bibkova ◽  
Dmitry S. Sudakov ◽  
Evdokia O. Bogdanova ◽  
Olga V. Galkina ◽  
Yulia R. Dymarskaya ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Genetic Test ◽  
Mineral Density ◽  
Vdr Gene ◽  
Vdr Gene Polymorphism

This study involved 89 postpartum and 97 nonpregnant women aged 20 to 35 years. The results of the genetic test were compared to bone mineral density (BMD) values. The lowest values of BMD were detected in the puerperas with the BB genotype of the BsmI gene, the tt genotype of the TaqI gene, the aa genotype of the ApaI gene, and the ff genotype of the FokI gene. In all the examined sections of the skeleton, with the combination of the four unfavorable genes, BMD values were the lowest.

scholarly journals Lack of Association between Body Weight, Bone Mineral Density and Vitamin D Receptor Gene Polymorphism in Normal and Osteoporotic Women

1999 ◽  
Vol 15 (4) ◽  
pp. 221-227 ◽  
Author(s):  
Massimo Poggi ◽  
Stefano Aterini ◽  
Laura Nicastro ◽  
Vincenzo Chiarugi ◽  
Marco Ruggiero ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
At Risk ◽  
Vitamin D ◽  
Body Weight ◽  
Gene Polymorphism ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Mineral Density ◽  
Vdr Gene ◽  
Vdr Gene Polymorphism

In an ethnically homogeneous population of women living in Tuscany, Italy, the relationships between age, body weight, bone mineral density and the vitamin D receptor (VDR) gene polymorphism were studied, with the objective of recognizing patients at risk for osteoporosis. In 275 women bone mineral density was measured by Dual Energy X-rays Absorptiometry (DEXA). In 50 of them the individual genetic pattern for VDR was evaluated by DNA extraction followed by PCR amplification of the VDR gene, and digestion with the restriction enzyme BsmI. Age and bone mineral density were inversely related (R2= 0.298). Body weight was associated with bone mineral density (R2= 0.059), but not with age. In osteoporotic women, mean (± SD) body weight was 59.9 ± 6.5 Kg, lower than that recorded in non osteoporotic women (64.2 ± 9.4 Kg), even though not significantly different (p = 0.18). No association was found between VDR gene polymorphism, bone density or body weight. The performance of anthropometric and genetic components appear to be poor, and, at least for the time being, bone mineral density measurement by means of MOC-DEXA represents the optimal method to detect women at risk for postmenopausal osteoporosis.

scholarly journals GIPR rs10423928 and bone-mineral density in postmenopausal women in Shanghai

2022 ◽  
Author(s):  
Lizhi Zhang ◽  
Jinwei He ◽  
Xiang Sun ◽  
Dongyue Pang ◽  
Jingjing Hu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Gene Polymorphism ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Bone Protection

Our previous studies have demonstrated that there is a correlation between GLP-1R SNP and the BMD in postmenopausal women. GLP-1 and GIP are both incretins. Whether the mutation of GIPR gene affects bone metabolism. SNP rs10423928 is a GIPR gene polymorphism that has been studied more frequently. The aim of this study was to investigate the association between GIPR SNP rs10423928 and bone-mineral density (BMD) in postmenopausal women in Shanghai. The GIPR SNP rs10423928 was detected in 884 postmenopausal women in Shanghai, the correlation between the GIPR SNP and BMD was further assessed. The dominant T/T genotype of the GIPR SNP rs10423928 was significantly related to BMD of the femoral neck (P = 0.035) and Ward’s triangle area (P = 0.033). Our research found that the dominant T/T genotype of GIPR SNP rs10423928 in postmenopausal women is significantly associated with higher BMD. The T/T genotype seems to have bone protection.

scholarly journals Correlation between hand bone mineral density and joint destruction in established rheumatoid arthritis

2017 ◽  
Vol 14 (4) ◽  
pp. 461-465 ◽  
Author(s):  
Takeshi Mochizuki ◽  
Koichiro Yano ◽  
Katsunori Ikari ◽  
Ryo Hiroshima ◽  
Yu Sakuma ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Joint Destruction ◽  
Established Rheumatoid Arthritis ◽  
Mineral Density
Sign in / Sign up

Export Citation Format

Share Document