AB0593 Choroidal Involvement in Systemic Sclerosis: Comparison between Skin Blood Perfusion and Choroidal Thickness before and after Iloprost Treatment

Abstract Background: Skin blood flux (SkBF) changes caused by drinking cold water are generally associated with vagal tone and osmotic factors in the digestive system. However, the distribution and regulation of bilateral blood flow are not symmetrical but exhibit a certain laterality. The aim of this study was to analyze the laterality of SkBF after drinking saline (0.9%) at different temperatures by monitoring blood flux in the bilateral lower extremities.Methods: A total of 60 subjects were recruited for this study, and all subjects completed all measurements. Subjects were randomly divided into a 4 °C group, 10 °C group and 30 °C group. For every subject, skin blood perfusion of bilateral Zusanli acupoints (ST 36) was recorded simultaneously before and after drinking 500 ml of 0.9% saline using a PeriFlux System 5000. The electrogastrogram (EGG) was also monitored, and the dominant frequency of the EGG and heart rate variability were analyzed.Results: The results indicated that after drinking saline at different temperatures, the laterality index of SkBF at the lower extremities was different. Drinking 30 °C saline can increase the laterality index of the lower extremities. Stimulation at 4 °C and 10 °C resulted in a decrease in the DF of the EGG and an increased RMSSD of the RR interval. Although this laterality is mainly contributed to by frequency interval V, there was a weak negative correlation between the laterality index of frequency interval I or II and RMSSD.Conclusion: There was laterality of blood perfusion in the lower extremities after drinking saline at different temperatures.

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Correlations between skin blood perfusion values and nailfold capillaroscopy scores in systemic sclerosis patients

Microvascular Research ◽

10.1016/j.mvr.2016.02.007 ◽

2016 ◽

Vol 105 ◽

pp. 119-124 ◽

Cited By ~ 24

Author(s):

B. Ruaro ◽

A. Sulli ◽

C. Pizzorni ◽

S. Paolino ◽

V. Smith ◽

...

Keyword(s):

Systemic Sclerosis ◽

Blood Perfusion ◽

Nailfold Capillaroscopy ◽

Skin Blood Perfusion

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Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures

10.21203/rs.3.rs-112441/v2 ◽

2020 ◽

Author(s):

Shuyong Jia ◽

Qizhen Wang ◽

Hongyan Li ◽

Xiaojing Song ◽

Shuyou Wang ◽

...

Keyword(s):

Cold Water ◽

Lower Extremities ◽

Blood Perfusion ◽

Dominant Frequency ◽

Frequency Interval ◽

Laterality Index ◽

Skin Blood Perfusion ◽

Before And After ◽

Different Temperatures ◽

Weak Negative Correlation

Abstract Background: Skin blood flux (SkBF) changes caused by drinking cold water are generally associated with vagal tone and osmotic factors in the digestive system. However, the distribution and regulation of bilateral blood flow are not symmetrical but exhibit a certain laterality. The aim of this study was to analyze the laterality of SkBF after drinking saline (0.9%) at different temperatures by monitoring blood flux in the bilateral lower extremities.Methods: A total of 60 subjects were recruited for this study, and all subjects completed all measurements. Subjects were randomly divided into a 4 °C group, 10 °C group and 30 °C group. For every subject, skin blood perfusion of bilateral Zusanli acupoints (ST 36) was recorded simultaneously before and after drinking 500 ml of 0.9% saline using a PeriFlux System 5000. The electrogastrogram (EGG) was also monitored, and the dominant frequency of the EGG and heart rate variability were analyzed.Results: The results indicated that after drinking saline at different temperatures, the laterality index of SkBF at the lower extremities was different. Drinking 30 °C saline can increase the laterality index of the lower extremities. Stimulation at 4 °C and 10 °C resulted in a decrease in the DF of the EGG and an increased RMSSD of the RR interval. Although this laterality is mainly contributed to by frequency interval V, there was a weak negative correlation between the laterality index of frequency interval I or II and RMSSD.Conclusion: There was laterality of blood perfusion in the lower extremities after drinking saline at different temperatures.

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Laterality of Blood Perfusion in the Lower Extremities after Drinking Saline at Different Temperatures

10.21203/rs.3.rs-112441/v1 ◽

2020 ◽

Author(s):

Shuyong Jia ◽

Qizhen Wang ◽

Hongyan Li ◽

Xiaojing Song ◽

Shuyou Wang ◽

...

Keyword(s):

Cold Water ◽

Lower Extremities ◽

Blood Perfusion ◽

Dominant Frequency ◽

Frequency Interval ◽

Laterality Index ◽

Skin Blood Perfusion ◽

Before And After ◽

Different Temperatures ◽

Weak Negative Correlation

Abstract Background: Skin blood flux (SkBF) changes caused by drinking cold water are generally associated with vagal tone and osmotic factors in the digestive system. However, the distribution and regulation of bilateral blood flow are not symmetrical but exhibit a certain laterality. The aim of this study was to analyze the laterality of SkBF after drinking saline (0.9%) at different temperatures by monitoring blood flux in the bilateral lower extremities.Methods: A total of 60 subjects were recruited for this study, and all subjects completed all measurements. Subjects were randomly divided into a 4 °C group, 10 °C group and 30 °C group. For every subject, skin blood perfusion of bilateral Zusanli acupoints (ST 36) was recorded simultaneously before and after drinking 500 ml of 0.9% saline using a PeriFlux System 5000. The electrogastrogram (EGG) was also monitored, and the dominant frequency of the EGG and heart rate variability were analyzed.Results: The results indicated that after drinking saline at different temperatures, the laterality index of SkBF at the lower extremities was different. Drinking 30 °C saline can increase the laterality index of the lower extremities. Stimulation at 4 °C and 10 °C resulted in a decrease in the DF of the EGG and an increased RMSSD of the RR interval. Although this laterality is mainly contributed to by frequency interval V, there was a weak negative correlation between the laterality index of frequency interval I or II and RMSSD.Conclusion: There was laterality of blood perfusion in the lower extremities after drinking saline at different temperatures.

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An open-label study to evaluate biomarkers and safety in systemic sclerosis patients treated with paquinimod

Arthritis Research & Therapy ◽

10.1186/s13075-021-02573-0 ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Roger Hesselstrand ◽

Jörg H. W. Distler ◽

Gabriela Riemekasten ◽

Dirk M. Wuttge ◽

Marie Törngren ◽

...

Keyword(s):

Systemic Sclerosis ◽

Type I ◽

Type I Ifn ◽

Open Label ◽

Reactive Protein ◽

Before And After ◽

Modified Rodnan Skin Score ◽

Skin Biopsies ◽

Rank 2

Abstract Objectives To evaluate the changes in disease-related biomarkers and safety of paquinimod, an oral immunomodulatory compound, in patients with systemic sclerosis (SSc). Methods In this open-label, single-arm, multicenter study, SSc patients with a rapidly progressive disease received paquinimod for 8 weeks. Blood and skin biopsies were collected at baseline, during treatment, and at follow-up for the analyses of type I interferon (IFN) activity, chemokine (C-C motif) ligand 2 (CCL2), and the number of myofibroblasts. The safety of paquinimod was evaluated throughout the study. Results Nine SSc patients were enrolled and completed the study treatment with paquinimod at 3 mg/day for 8 weeks. After the treatment, a reduction of type I IFN activity in the plasma from one patient with elevated baseline IFN activity was recorded. A trend towards reduced IFN activity in the skin after treatment was also observed in patients. The serum level of CCL2 was reduced in 7 of 9 patients after paquinimod treatment. There was a median reduction of 10% of the number of myofibroblasts in skin biopsies at week 8 compared to baseline. No change in modified Rodnan skin score and quality of life was detected in the study. Reported adverse events (AEs) were mild to moderate and expected with the most common being arthralgia (n = 3) and headache (n = 3), and C-reactive protein (CRP) increase. Conclusions Analysis of biomarkers before and after treatment suggest reduced type I IFN activity and reduced number of myofibroblasts in lesional skin. Paquinimod was overall well tolerated with mild to moderate and expected AEs. Trial registration ClinicalTrials.gov, NCT01487551. Registered on 7 September 2011

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