scholarly journals THU0601 SALIVARY GLAND ULTRASONOGRAPHY FOR SJÖGREN SYNDROME AND SICCA SYMPTOMS WITH EVALUATION THE DIFFERENT IMAGE PARAMETERS AND BIOPSY RESULT

2019 ◽  
Author(s):  
Yen Po Tsao ◽  
Ming Han Chen ◽  
Wei Sheng Chen ◽  
Chang-Youh Tsai
Keyword(s):  
Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Biopsy Result ◽  
Sicca Symptoms

Salivary Gland Ultrasonography as a Diagnostic Tool for Secondary Sjögren Syndrome in Rheumatoid Arthritis

2015 ◽  
Vol 42 (7) ◽  
pp. 1119-1122 ◽  
Author(s):  
Sunil Das ◽  
DoQuyen Huynh ◽  
Hong Yang ◽  
Arnoldas Ceponis ◽  
Arthur Kavanaugh
Keyword(s):  
Rheumatoid Arthritis ◽  
Salivary Gland ◽  
Oral Health ◽  
Disease Activity ◽  
Diagnostic Tool ◽  
Scoring System ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Sicca Symptoms

Objective.To assess salivary gland ultrasonography (US) as a diagnostic tool for secondary Sjögren syndrome (sSS) in patients with rheumatoid arthritis (RA).Methods.Salivary gland US images from 30 patients with RA were graded using a validated semiquantitative scoring system. Sicca symptoms, oral health, and RA disease activity were assessed.Results.US changes consistent with SS were found in 40% of patients. Patients with higher US scores had more sicca symptoms as well as higher RA activity and poorer oral health.Conclusion.Salivary gland US may aid the diagnosis of sSS in patients with RA.

scholarly journals Comparison of Effect on Sicca Symptoms of Anticentromere Antibody–positive Sjögren Syndrome and Primary Sjögren Syndrome Alone

2019 ◽  
Vol 47 (6) ◽  
pp. 876-880
Author(s):  
Yifan Li ◽  
Arthur A.M. Bookman
Keyword(s):  
Salivary Gland ◽  
Physical Examination ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Anticentromere Antibody ◽  
Primary Sjögren Syndrome ◽  
European Consensus ◽  
Significant Difference ◽  
Sicca Symptoms

Objective.To determine whether positive anticentromere antibody (ACA) serology affects the severity of sicca symptoms in patients with primary Sjögren syndrome (pSS).Methods.Evaluation to detect subjective and objective sicca symptoms included questionnaires, physical examination, and pathology. Cases of pSS were classified according to the 2002 American-European Consensus Group (AECG) criteria. All patients were evaluated for presence of anti-Ro, anti-La, and ACA serology. Patients with pSS were categorized into ACA+ SS and ACA–SS. The groups were compared for measures of severity of oral and ocular sicca.Results.The pSS group had 446 patients, of whom 26 were ACA+ SS. Subjective ocular sicca measured 7.0 ± 2.4 (out of 10) in ACA+ SS and 6.4 ± 2.6 in ACA–SS (p = 0.197). Objective ocular sicca measured 3.2 mm ± 1.8 mm/5 min in ACA+ SS and 4.2 mm ± 4.4 mm/5 min in ACA–SS (p = 0.038). Subjective oral sicca measured 8.5 ± 1.4 in ACA+ SS and 6.7 ± 2.4 in ACA–SS (p < 0.001). Objective oral sicca measured 0.1 ml ± 0.2 ml/15 min in ACA+ SS and 0.4 ml ± 1.0 ml/15 min in ACA–SS (p < 0.001). Only 35% of ACA+ patients with SS were anti-Ro–positive or anti-La–positive compared with 77% of the ACA–patients with SS (p < 0.001). There was no significant difference in minor salivary gland fibrosis or focus scores between ACA+ SS and ACA–patients with SS.Conclusion.ACA+ SS is associated with more severe objective ocular sicca and more severe subjective and objective oral sicca compared to ACA–SS. The majority of ACA+ patients with SS meet AECG criteria for pSS despite negative serology for anti-Ro/La antibodies.

scholarly journals Disease-Induced Changes in Salivary Gland Function and the Composition of Saliva

2021 ◽  
pp. 002203452110048
Author(s):  
G.B. Proctor ◽  
A.M. Shaalan
Keyword(s):  
Salivary Gland ◽  
Sjögren Syndrome ◽  
Healthy Population ◽  
Sjogren Syndrome ◽  
Salivary Gland Function ◽  
Salivary Gland Dysfunction ◽  
Gland Function ◽  
And Function ◽  
The Impact ◽  
Saliva Composition

Although the physiological control of salivary secretion has been well studied, the impact of disease on salivary gland function and how this changes the composition and function of saliva is less well understood and is considered in this review. Secretion of saliva is dependent upon nerve-mediated stimuli, which activate glandular fluid and protein secretory mechanisms. The volume of saliva secreted by salivary glands depends upon the frequency and intensity of nerve-mediated stimuli, which increase dramatically with food intake and are subject to facilitatory or inhibitory influences within the central nervous system. Longer-term changes in saliva secretion have been found to occur in response to dietary change and aging, and these physiological influences can alter the composition and function of saliva in the mouth. Salivary gland dysfunction is associated with different diseases, including Sjögren syndrome, sialadenitis, and iatrogenic disease, due to radiotherapy and medications and is usually reported as a loss of secretory volume, which can range in severity. Defining salivary gland dysfunction by measuring salivary flow rates can be difficult since these vary widely in the healthy population. However, saliva can be sampled noninvasively and repeatedly, which facilitates longitudinal studies of subjects, providing a clearer picture of altered function. The application of omics technologies has revealed changes in saliva composition in many systemic diseases, offering disease biomarkers, but these compositional changes may not be related to salivary gland dysfunction. In Sjögren syndrome, there appears to be a change in the rheology of saliva due to altered mucin glycosylation. Analysis of glandular saliva in diseases or therapeutic interventions causing salivary gland inflammation frequently shows increased electrolyte concentrations and increased presence of innate immune proteins, most notably lactoferrin. Altering nerve-mediated signaling of salivary gland secretion contributes to medication-induced dysfunction and may also contribute to altered saliva composition in neurodegenerative disease.

Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjögren Syndrome and Age-matched Controls

2014 ◽  
Vol 41 (6) ◽  
pp. 1178-1182 ◽  
Author(s):  
Naoto Yokogawa ◽  
Scott M. Lieberman ◽  
Faizan Alawi ◽  
Sharon Bout-Tabaku ◽  
Marta Guttenberg ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Sjögren Syndrome ◽  
Classification Criteria ◽  
Sjogren Syndrome ◽  
Labial Salivary Gland ◽  
Focus Score ◽  
Salivary Gland Tissue ◽  
Gland Tissue ◽  
Control Samples

Objective.To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS).Methods.Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.Results.The presence of any focal sialadenitis (focus score > 0 foci/4 mm2) was common among childhood SS samples but present in only 1 of 8 control samples.Conclusion.The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.

FRI0311 Is ultrasonography of salivary gland a useful tool in sjögren syndrome? a systematic review.

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A479.3-A480
Author(s):  
S. Jousse-Joulin ◽  
S. Bowman ◽  
V. Milic ◽  
M. V. Jonsson ◽  
A. Plagou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Salivary Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome

scholarly journals Minor Salivary Gland Inflammatory Lesions in Sjögren Syndrome: Do They Evolve?

2013 ◽  
Vol 40 (9) ◽  
pp. 1566-1571 ◽  
Author(s):  
Efstathia K. Kapsogeorgou ◽  
Maria I. Christodoulou ◽  
Demosthenes B. Panagiotakos ◽  
Spyros Paikos ◽  
Anna Tassidou ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Cell Types ◽  
Sjögren Syndrome ◽  
Time Interval ◽  
Sjogren Syndrome ◽  
T And B Cells ◽  
Biopsy Specimens ◽  
Lymphocytic Infiltrates ◽  
Significant Disease

Objective.The lymphocytic infiltrates of minor salivary gland (MSG) lesions of Sjögren syndrome (SS) vary in grade and composition and are generally thought to develop in stepwise manner. Their progression over time is not well defined.Methods.We studied repetitive MSG biopsy specimens from 28 patients with primary SS.Results.The infiltration grade and prevalence of the major infiltrating cell types (T and B cells, macrophages, dendritic cells, natural killer cells) remained largely unchanged during a median 55 month biopsy time interval followup (quartiles 42–81).Conclusion.We found significant disease progression involving the development of mucosa-associated lymphoid tissue lymphoma in patients expressing adverse serologic prognostic factors, such as low serum C4 complement levels and cryoglobulinemia.

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