AB1012 INVESTIGATION OF RELATIONSHIP BETWEEN SEXUAL FUNCTION AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH BEHÇET’S: PRELIMINARY STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1799-1800
Author(s):  
A. Ayan ◽  
M. F. Kucuk ◽  
S. Y. Cetin ◽  
M. K. Erol
Keyword(s):  
Optical Coherence Tomography ◽  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Sexual Satisfaction ◽  
Erectile Function ◽  
Positive Relationship ◽  
Optical Coherence Tomography Angiography ◽  
Depression And Anxiety ◽  
Strong Positive Relationship ◽  
Preliminary Study

Background:Patients with Behçet’s have sexual dysfunction in recently literature. However, depression and anxiety accompanying these studies were not excluded. In addition, increased sexual dysfunction in patients with Behçet’s has been reported in these studies in relation to depression and anxiety. Also it has been stated that endothelial dysfunction decreases the vasodilator neurotransmitter level. It was emphasized that this may lead to erectile dysfunction in disease of Behçet’s.Objectives:The aim of this study is to evaluate the relationship between erectile dysfunction (ED) and radial peripapillary capillary (RPC) density determined by Optical Coherence Tomography Angiography (OCTA).Methods:Patients under 45 years old who had no known additional disease and had no eye and neurological involvement were included in the study. The patients were evaluated with Beck Depression and Anxiety Scale. Accordingly, patients without anxiety and depression were included in the study. An International Index of ErectileFunction (IIEF) questionnaire was applied to a total of 18 patients who met the inclusion criteria. Detailed ophthalmological examination and OCTA imaging were performed by the ophthalmologist. Patients whose eye bottom could not be evaluated clearly (Corneal pathology, cataracts, etc.), image quality was 0.5 and below, and additional eye disease (glaucoma, optic neuropathy, maculopativb) were excluded from the study.Results:The mean age of the patients was 37 ± 6.5 years, and the duration of the disease was 82.37 ± 47.78 months. There was a strong relationship between RPC Small Vessel Whole Density (RPC-SVWD) and overall satisfaction and sexual satisfaction (p: 0.036 and 0.045). There was a strong positive relationship between RPC Small Vessel Peripapillary Density (RPC-SVPD) and erectile function, sexual desire, sexual satisfaction and general satisfaction (p: 0.036, 0.032, 0.005, 0.004). There was a strong positive relationship between RPC All Vessel Peripapillary Density (RPC-AVPD) and erectile function and sexual satisfaction (p: 0.048, 0.015).Conclusion:In our study, a significant relationship was found between sexual function and RPC density. In the literature, it has been found that nitric oxide synthesis decreases due to endothelial dysfunction in patients with Behçet’s. Although there are preliminary study data, we found a significant relationship between the vascular layer of both the penis and the eye in our study. The data we obtained in this study, in which all factors that may cause erectile dysfunction are excluded, show that Behçet’s, which is theoretically known to affect all vascular structures, can affect sexual functions by its nature. In our study, although there is a relationship between ED and OCTA data in Behçet’s disease, the large number of cases of our ongoing study will provide clearer information.References:[1]Erdemir F, Atilgan D, Boztepe Ö, Aytan P, Uluocak N, Taliyurt T. Is there a relationshipbetween Behçet disease and erectile dysfunction? Turkish Journal of Urology 2010; 36:380-386.[2]Rosen RC, Riley A, Wagner G Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectilefunction (IIEF): a multidimensional scale for assesment of erectile dysfunction. Urology 1997; 49: 822–830.[3]Validation Group of Turkish Society of Andrology. International Index of Erectile Function (IIEF) Turkish version, 4th National Sexual Dysfunction Congress Abstract Book, pp 43, 2002.[4]Örem A, Ertürk M, Cimşit G, Kural BV. Effect of plasma from patients with Behçet disease on the production of nitricoxide in cultured human umbilical vein endothelial cells. Med Princ Pract 2004;13:35-8.Disclosure of Interests:None declared

scholarly journals Effects of Two Different Dosages of Sildenafil on Patients With Erectile Dysfunction

2015 ◽  
Vol 11 (3) ◽  
pp. 525-530 ◽  
Author(s):  
Hongjun Li ◽  
Gang Bai ◽  
Xinyu Zhang ◽  
Bingbing Shi ◽  
Defeng Liu ◽  
...  
Keyword(s):  
Health Care ◽  
Erectile Dysfunction ◽  
Sexual Intercourse ◽  
Health Care Providers ◽  
Sexual Satisfaction ◽  
Erectile Function ◽  
Care Providers ◽  
Self Assessment ◽  
Sexual Enjoyment

To investigate the effects of two different dosages of sildenafil on patients with erectile dysfunction (ED), a total of 3,674 patients with ED were recruited to answer questionnaires designed specifically for this study. There were 977 patients in the 50 mg group and there were 2,697 patients in the 100 mg group. Both 50 mg and 100 mg of sildenafil therapy increased the ED patients’ average monthly frequency of sexual intercourse, improved erectile function state in self-assessment, and elevated sexual satisfaction and enjoyment. Despite a higher rate of concomitant diseases, patients in the higher dosage of sildenafil group had a better outcome in the average monthly frequency of sexual intercourse and sexual enjoyment compared with those in the lower dosage. Such a study might be helpful for health care providers to choose sildenafil dosage for patients with ED.

Erectile Dysfunction in War Veterans in Bosnia-Herzegovina

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
E. Becirovic ◽  
E. Avdibegovic
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Sexual Functioning ◽  
Erectile Function ◽  
Stress Disorder ◽  
Traumatic Experiences ◽  
Drug Addicts ◽  
Ptsd Symptoms ◽  
War Veterans ◽  
Harvard Trauma Questionnaire

Results of previous studies suggest that people with traumatic experiences frequently have sexual problems. This study aimed to assess erectile function in war veterans. One hundred and five war veterans were tested using the Harvard Trauma Questionnaire (HTQ) and the International Index of Erectile Function (IIEF). They were divided into two groups; those with symptoms of Posttraumatic Stress Disorder (PTSD) and those without, measured with the HTQ. We tested war veterans that hadn"t been using psychotropic or other medications that could cause sexual dysfunction and who did not have either a physical or psychological disease and were not alcohol or drug addicts. The average age of the group tested was 40.84±5.94 years. All participants had had a sexual partner for longer than 6 months. We found that 67.6% of all tested veterans showed below normal erectile function. Average results of erectile function in both groups were 22.10±5.73 as measured by the IIEF. Participants without PTSD symptoms had significantly better results of erectile functioning (χ2=44.62, p=0.001). There was a significant negative corrrelation (p<0.01) between the intensity of PTSD symptoms of intrusion, avoidance and hyperarousal and the intensity of sexual dysfunction as measured by the IIEF. War veterans with more intensive symptoms of PTSD and a higher number of traumatic experiences have more problems with sexual functioning.

scholarly journals Evaluation of Therapy Effectiveness in Men with Different Erectile Dysfunction Severity

Health of Man ◽  
2021 ◽  
pp. 71-78
Author(s):  
Volodymyr Trishch ◽  
Andrii Mysak
Keyword(s):  
Erectile Dysfunction ◽  
Combination Therapy ◽  
Sexual Intercourse ◽  
Sexual Satisfaction ◽  
Erectile Function ◽  
Control Group ◽  
Healthy Men ◽  
Group I ◽  
Group Ii

Sexual health is an integral part of everyone’s quality of life. Sexual harmony depends on a man’s sexual desire and erectile function. The most common disorder of male sexual health is erectile dysfunction. Improving the treatment of patients with this pathology helps to improve both physical and mental health and thus improve the quality of life. The objective: the aim of the study was to evaluate the efficacy and safety of combination course therapy and monotherapy in patients with erectile dysfunction. Materials and methods. The observation included 89 men with erectile dysfunction of mixed genesis aged 25 to 50 years with mild to moderate severity. All patients were divided into three groups. The I group of 32 patients with moderate ED, received during the month in the morning Bodrex 1 sachet 60 minutes before meals and in the evening Strondex one spray into the oral cavity (12,5 mg sildenafil), regardless of the presence or absence of sexual activity in this day and an additional 30 minutes before sexual intercourse from 12,5 to 25 mg, followed by a comparative assessment of clinical results immediately after treatment in relation to a group of patients (II group – 32), also with moderate ED who received sildenafil in tablet form dose of 25 mg 1 hour before sexual intercourse, but not more often than once a day. The third group (III group – 25) of patients consisted of men with mild ED, who received during the month only Bodrex in the morning 1 sachet 60 minutes before meals, with comparing clinical data before and after treatment. Bodrex and Strondex preparations are presented on the market by the pharmaceutical company Geolik Pharm Marketing Group. Results. The use of course combination therapy (Strondex + Bodrex) in the treatment of patients with moderate ED was found to be significantly more effective than sildenafil monotherapy at a dose of 50 mg on demand before sexual intercourse, as evidenced by subjective assessment of patients and objective data. Namely, the integrative indicator «erectile function» in this group of patients improved almost twice, while in the second group of patients this indicator improved by 62,9% (p<0,05). Accordingly «оverall satisfaction" in group I patients improved 2,3 times, and in group II patients 1,8 times. Dopplerosonography of the penis in patients with moderate ED showed a probable decrease in hemodynamics in the corpora cavernosa, which indicated the presence of vascular factor with impaired vascular endothelial function (p<0,05). After treatment, a more pronounced increase in cavernous blood flow occurred in group I, namely an increase in peak systolic velocity by 69,5%, while in group II by 38,5% (p1<0,05). It was noted that the concentration of ET-1 in the serum of patients with moderate ED was 3 times higher than the average in the group of almost healthy men, which may indicate severe endothelial dysfunction (p<0,05). Accordingly, after treatment, the level of ET-1 in the blood of patients decreased in group I, who received combination therapy, by 44,2%, while in group II by 28,3% (p1<0,05). Before treatment, the majority of patients with moderate ED, namely 78,1%, could not have sexual intercourse due to insufficient erection. After treatment in 53,1% of group I patients receiving combination therapy (Strondex + Bodrex), erection was completely restored, while in group II erection was completely restored in 28,1% of patients. Also, according to the obtained data, it should be noted a significant positive dynamics of all integrative indicators of IIEF on the background of taking Bodrex in patients with mild ED (p<0,05). An increase in the baseline «erectile function» by 1,4 times, contributed to an increase in sexual satisfaction and sexual satisfaction in general by 2,3 times. The mean peak systolic rate of cavernous blood flow before treatment in this group of patients was lower compared with the control group by 21,2% (p<0,05). This indicator improved after treatment by 21,7%, and became not significantly different from this indicator in the control group of almost healthy men (p1<0,05; p2>0,05), which indicated the normalization of hemodynamics in penis. In patients with mild ED, the concentration of ET-1 in the serum was 1,7 times higher than in the control group (p<0,05). After treatment, this index decreased by 1.5 times, approaching the rate in the group of almost healthy men (p2>0,05). Before treatment in this group, no patient had a complete erection, and less than half of the patients (45,5%) had a pratial erection. After a course of treatment with Bodrex, complete erection was restored in 68,2% of patients, and a total of 86,4% of patients were able to have sexual intercourse. Conclusions. The use of combination course therapy (Strondex + Bodrex) in patients with moderate ED and course monotherapy (Bodrex) in patients with mild ED contributes to a more stable clinical effect, as evidenced by the dynamics of the data.

scholarly journals Cross Sectional Survey of Priapism and Sexual Dysfunction in 353 Men with Sickle Cell Disease

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 2302-2302
Author(s):  
Ibrahim Musa Idris ◽  
Jamil Aliyu Galadanci ◽  
Akib Abba ◽  
Sharfuddeen Abbas Mashi ◽  
Anele Uzoma ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Focus Group ◽  
Sexual Function ◽  
Sickle Cell ◽  
Sexual Desire ◽  
Erectile Function ◽  
Clinical Epidemiology ◽  
Cross Sectional ◽  
Significant Difference

Introduction: In both high and low income countries, life span in sickle cell disease (SCD) is increasing and quality of life is improving. Recent research activities have focused on decreasing SCD-related morbidities. However, limited research has been done on clinical epidemiology of priapism, sexual dysfunction and libido in men with SCD. As part of our ongoing Priapism in Nigeria (PIN) cohort to assess knowledge gap in clinical epidemiology of priapism and sexual dysfunction in men with SCD, we tested the hypothesis that sexual dysfunction is high in men with SCD compared to age/race matched men without SCD. Methods: We utilized a mixed method study design (cross-sectional survey and focus group discussions) in men, aged 18-40 years, with confirmed SCD and men without SCD as comparators for the survey. Participants were recruited from the adult sickle cell clinic and general outpatients department of Aminu Kano Teaching Hospital (AKTH) and Murtala Mohammed Specialists Hospital (MMSH) in Kano, Nigeria from February to July 2019. Priapism is defined as a purposeless painful erection, unrelated to sexual desire; and mostly occurs in the stuttering or recurrent ischemic form, which lasts less than 4 hours. We used the validated International Index of Erectile Function (IIEF) questionnaire to assess erectile dysfunction in this population. Additionally, we conducted 6 focus group discussions in Nigeria (3 sessions) and United States (3 sessions), respectively; in which we asked open ended questions about symptoms, experiences, beliefs and life impacts of priapism. Data were presented as means ± standard deviation or proportions with 95% Confidence Intervals. The t-test and Chi square test were used to compare demographic data. Similarly, domain-specific scores, which included: 1) erectile function, 2) sexual desire, 3) orgasmic function, 4) overall satisfaction with sex life, and 5) intercourse satisfaction- were compared between the two groups using t-test; where higher scores indicate better sexual function. Erectile domain was further sub-classified into normal (26-30), mild ED (22-25), mild-moderate ED (17-21), moderate ED (11-16) and severe ED (0-10). We considered alpha level of significance to be <0.05. The focus group data was analyzed using an iterative inductive/deductive approach. Results: A total of 353 men with SCD and 250 men without SCD were evaluated; for the demographic features the only significant difference was in monthly income (p 0.007) with SCD being higher, table 1. The prevalence of any priapism episode (major or stuttering) in men with and without SCD was 31.72% (112 of 353) and 2% (5 of 250). Among men with SCD, 25.9% (29 of 112) and 74.1% (83 of 112) had major and stuttering priapism episodes, respectively. Based on the IIEF, the men with SCD when compared to men without SCD had significantly lower total mean scores (24.9 vs 29.6, p 0.0002), erectile function (9.9 vs 11.5, p 0.005), sexual desire (5.8 vs 7.1, p<0.0001), and overall satisfaction with sex life (2.3 vs 3.5, p<0.0001). No significant difference in orgasmic function (p=0.29) and intercourse satisfaction (p=0.12) was observed. Among the married men with and without SCD, 55% (21 of 38) and 84% (22 of 26) had normal erectile function, and 26.3% (10 of 38) and 11.5% (3 of 26) had severe erectile dysfunction, respectively. Based on the data from our focus groups with a total of 28 and 7 participants (n=35), in Nigeria and United States respectively, we were guided by biopsychosocial and socio-ecological models to develop a conceptual framework (not shown). We identified themes on cultural context, priapism (triggers, schema, episodes and coping strategies), emotional and sexual function impacts, with respective quotes (results not shown). Conclusions: In the largest cross-sectional and qualitative study of priapism in men with SCD to date, we demonstrated that priapism and sexual dysfunction are significant cause of morbidity when compared to men without SCD. Married participants with SCD have 2-fold greater proportion of severe erectile dysfunction than those without SCD. Our qualitative results revealed tremendous impact of priapism and sexual dysfunction in men with SCD. Participants with priapism experience shame, anxiety and depression, and declined sexual function. There was diversity in causal attribution and coping strategies of priapism. Disclosures Idris: Fogarty International Center: Research Funding.

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