PO-0357 Prenatal Exposure To Endocrine Disrupting Chemicals (edcs) In Relation To Thyroid Hormone Levels In Infants

AbstractIn this systematic review, the association between prenatal exposure to organochlorine pesticides (OCPs) and neonatal thyroid hormone levels was studied. A systematic search of scientific literature was performed from the PubMed, SCOPUS and ISI web of science electronic bibliographic databases. The search strategy for the review was [(organochlorine OR “organochlorine pesticides” OR “organochlorine pollutants” OR “organochlorine pollutant”) AND (“thyroid hormone” OR triiodothyronine OR Thyroxine OR “fetal thyroid function” OR “thyroid function” OR “Thyroid Stimulating Hormone” AND “prenatal” AND “maternal exposure”)] in English sources. In this review, 305 papers (PubMed: 30; Scopus: 29; ISI: 246) were identified through an electronic database search. Twenty-seven articles were assessed for eligibility, from which 16 qualified articles were selected for the final evaluation. The most common OCP metabolites which were evaluated in order were hexachlorobenzene (HCB) (13 studies), pp-dichlorodiphenyldichloroethylene (pp-DDE) (13 studies), hexachlorocyclohexane (HCH) (10 studies) and dichlorodiphenyltrichlorethane (DDT) (eight studies). A review of the documents related to the association of prenatal exposure of OCPs with fetal or neonatal thyroid function tests provides us with heterogeneous data in this field. Factors such as differences in the studied populations and their area, ethnic and genetic background, time and rate of exposure, possible interaction of other thyroid-disrupting environmental factors and dietary intake of micronutrients such as iodine and/or selenium are considered the main limitations for making an accurate conclusion. For some OCPs including DDT, DDE, HCH and HCB, there are supporting evidences, and it is suggested that their exposure could potentially alter the fetal thyroid function and consequently impair the neurodevelopment process of the infants.

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The association between prenatal exposure to organochlorine pesticides and thyroid hormone levels in newborns in Yancheng, China

Environmental Research ◽

10.1016/j.envres.2013.12.009 ◽

2014 ◽

Vol 129 ◽

pp. 47-51 ◽

Cited By ~ 33

Author(s):

Chengcheng Li ◽

Yibin Cheng ◽

Quan Tang ◽

Shaobin Lin ◽

Yonghong Li ◽

...

Keyword(s):

Thyroid Hormone ◽

Organochlorine Pesticides ◽

Prenatal Exposure ◽

Hormone Levels ◽

Thyroid Hormone Levels

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Association between prenatal exposure to multiple metals and maternal and child thyroid hormone levels

Environmental Epidemiology ◽

10.1097/01.ee9.0000608760.49099.fd ◽

2019 ◽

Vol 3 ◽

pp. 260

Author(s):

Margetaki K ◽

Vafeiadi M ◽

Roumeliotaki T ◽

Karakosta P ◽

Daraki V ◽

...

Keyword(s):

Thyroid Hormone ◽

Prenatal Exposure ◽

Hormone Levels ◽

Thyroid Hormone Levels

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Longitudinal Study of Thyroid Hormones between Conventional and Organic Farmers in Thailand

Toxics ◽

10.3390/toxics8040082 ◽

2020 ◽

Vol 8 (4) ◽

pp. 82

Author(s):

Noppanun Nankongnab ◽

Pornpimol Kongtip ◽

Nichcha Kallayanatham ◽

Ritthirong Pundee ◽

Jutharak Yimsabai ◽

...

Keyword(s):

Thyroid Hormone ◽

Mixed Model ◽

Linear Mixed Model ◽

Longitudinal Impact ◽

Free Triiodothyronine ◽

Hormone Levels ◽

Endocrine Disrupting ◽

Organic Farmers ◽

Thyroid Hormone Levels ◽

The Impact

Many pesticides are endocrine-disrupting chemicals that can interfere with hormone levels. This study aimed to assess the longitudinal impact of exposure to pesticides on thyroid hormone levels, including Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (FT3), Free Thyroxine (FT4), Triiodothyronine (T3), and Thyroxine (T4). Both conventional (i.e., pesticide using) and organic farmers were interviewed using questionnaires, and blood samples were collected at 7–9 a.m. to determine thyroid hormone levels for four rounds, with a duration of eight months between each round. A linear mixed model of the natural log of the individual hormone levels used random intercepts for subjects while controlling gender, baseline age, and body mass index (BMI) was used to compare between conventional and organic farmers or the impact of cumulative days of spraying insecticides, herbicides or fungicides. The estimated marginal means of the thyroid hormone levels (TSH, FT3, T3, and T4) estimated from the linear mixed models were significantly higher among the conventional farmers than organic farmers. As cumulative spray days of insecticide, herbicide or fungicide increased, TSH and FT3 increased significantly. FT4 decreased significantly as cumulative spray days of insecticide or fungicide increased. These findings suggest that the insecticides, herbicides, and fungicides sprayed by conventional farmers exert endocrine-disrupting activities, altering the hypothalamic-pituitary-thyroid (HPT) axis homeostasis.

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Associations of Prenatal Exposure to Triclosan and Maternal Thyroid Hormone Levels: A Systematic Review and Meta-Analysis

Frontiers in Endocrinology ◽

10.3389/fendo.2020.607055 ◽

2021 ◽

Vol 11 ◽

Author(s):

Danrong Chen ◽

Jiani Liu ◽

Wu Yan ◽

Kacey Fang ◽

Yankai Xia ◽

...

Keyword(s):

Thyroid Hormone ◽

Prenatal Exposure ◽

Meta Analysis ◽

Descriptive Analysis ◽

Cochrane Library ◽

Hormone Levels ◽

Thyroid Hormone Levels ◽

Maternal Thyroid ◽

The Relationship ◽

Tsh Levels

ObjectiveTo quantitatively evaluate associations between exposure to triclosan during pregnancy and maternal thyroid hormone levels.MethodThe databases of PubMed, Embase, Web of Science and Cochrane Library were systematically searched to identify relevant studies on the relationship between prenatal exposure to triclosan and maternal levels of serum thyroid hormone published before October 22, 2019. Stata 12.0 was used to examine the heterogeneity among the eligible studies.ResultsSeven studies involving a total of 4,136 participants were included. Overall, descriptive analysis provided no indication that exposure to TCS during pregnancy was related to either maternal FT4 levels (ES = 0.01, 95% CI: −0.03 to 0.05, P = 0.00) or TSH levels (ES = −0.03, 95% CI: −0.13 to 0.07, P = 0.412). Although the results were statistically insignificant, with the increase of urine TCS concentration, maternal FT4 levels exhibited a tendency to increase while TSH levels had a tendency to decrease during pregnancy.ConclusionThe results indicated that exposure to triclosan during pregnancy has no significant influence on maternal levels of thyroid hormone. On account of the inconsistency of existing research designs and study locations, further studies and replication are necessary to confirm these findings.

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