The natural history of bone marrow lesions in community-based adults with no clinical knee osteoarthritis

Objectives:To describe the natural history of subchondral bone marrow lesions (BMLs) in a sample of subjects with knee osteoarthritis (OA) or at risk of developing it. Additionally, to examine the association of change in BMLs from baseline to 30-month follow-up with the risk of cartilage loss in the same subregion at follow-up.Methods:1.0 T MRI was performed using proton density-weighted, fat-suppressed sequences. BML size and cartilage status were scored in the same subregions according to the WORMS system. Subregions were categorised based on comparison of baseline and follow-up BML status. A logistic regression model was used to assess the association of change in BML status with cartilage loss over 30 months using stable BMLs as the reference group.Results:395 knees were included. 66% of prevalent BMLs changed in size; 50% showed either regression or resolution at follow-up. The adjusted odds ratios (95% confidence intervals) of cartilage loss in the same subregion at follow-up for the different groups were 1.2 (0.5 to 1.6) for regressing BMLs, 0.9 (0.5 to 1.6) for resolving BMLs, 2.8 (1.5 to 5.2) for progressing BMLs, 0.2 (0.1 to 0.3) for subregions with no BMLs at baseline and follow-up and 3.5 (2.1 to 5.9) for newly developing BMLs. BML size at baseline was associated with risk of subsequent cartilage loss.Conclusions:The majority of pre-existing BMLs decreased in size at follow-up. Absence of BMLs was associated with a decreased risk of cartilage loss, while progressing and new BMLs showed a high risk of cartilage loss in the same subregion.

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The Natural History of Knee Osteoarthritis: India-based Knee Osteoarthritis Evaluation (iKare): A Study Protocol

Journal of Long-Term Effects of Medical Implants ◽

10.1615/jlongtermeffmedimplants.2013010138 ◽

2013 ◽

Vol 23 (2-03) ◽

pp. 93-104

Author(s):

Alexa Gilbert ◽

Chuan Silvia Li ◽

Parag Sancheti ◽

Beate Hanson ◽

Mandeep S. Dhillon ◽

...

Keyword(s):

Natural History ◽

Knee Osteoarthritis ◽

Study Protocol ◽

History Of

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Faculty Opinions recommendation of Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13901.471406 ◽

2006 ◽

Author(s):

Elizabeth Arner

Keyword(s):

Magnetic Resonance Imaging ◽

Bone Marrow ◽

Magnetic Resonance ◽

Knee Osteoarthritis ◽

Imaging Study ◽

Cartilage Loss ◽

Magnetic Resonance Imaging Study ◽

Resonance Imaging ◽

Bone Marrow Lesions

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Greater heterogeneity of the bone mineralisation density distribution and low bone matrix mineralisation characterise tibial subchondral bone marrow lesions in knee osteoarthritis patients

Bone ◽

10.1016/j.bone.2021.115979 ◽

2021 ◽

Vol 149 ◽

pp. 115979

Author(s):

Yea-Rin Lee ◽

David M. Findlay ◽

Dzenita Muratovic ◽

Julia S. Kuliwaba

Keyword(s):

Bone Marrow ◽

Knee Osteoarthritis ◽

Density Distribution ◽

Subchondral Bone ◽

Bone Matrix ◽

Bone Marrow Lesions ◽

Bone Mineralisation ◽

Matrix Mineralisation

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The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study

Arthritis & Rheumatism ◽

10.1002/art.34415 ◽

2012 ◽

Vol 64 (7) ◽

pp. 2243-2251 ◽

Cited By ~ 73

Author(s):

K. M. Leyland ◽

D. J. Hart ◽

M. K. Javaid ◽

A. Judge ◽

A. Kiran ◽

...

Keyword(s):

Cohort Study ◽

Natural History ◽

Knee Osteoarthritis ◽

Population Based ◽

History Of ◽

Radiographic Knee Osteoarthritis

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Natural history of mixed chimerism after bone marrow transplantation with CD6-depleted allogeneic marrow: a stable equilibrium

Blood ◽

10.1182/blood.v75.1.296.bloodjournal751296 ◽

1990 ◽

Vol 75 (1) ◽

pp. 296-304 ◽

Cited By ~ 1

Author(s):

DC Roy ◽

R Tantravahi ◽

C Murray ◽

K Dear ◽

B Gorgone ◽

...

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Natural History ◽

Marrow Transplantation ◽

Cytogenetic Analysis ◽

Common Finding ◽

Mixed Chimerism ◽

Allogeneic Bone ◽

Donor Cells ◽

History Of

Mixed hematopoietic chimerism (MC) is a common finding after allogeneic bone marrow transplantation (BMT), but the natural history of this phenomenon remains unclear. To understand the evolution and the implications of this finding, we performed a prospective analysis of the development of mixed chimerism in 43 patients with hematologic malignancies who received bone marrow (BM) from human leukocyte antigen (HLA)-identical sibling donors. T-cell depletion in vitro with anti-T12 (CD6) monoclonal antibody and rabbit complement was used as the only method of graft-versus-host disease (GVHD) prophylaxis. Overall, MC was identified in peripheral blood (PB) and BM in 22 of 43 (51%) patients evaluated. MC was found by restriction fragment length polymorphism (RFLP) analysis in 21 of 40 (53%) patients, by cytogenetic analysis in 6 of 29 (21%) patients, and by red blood cell phenotyping in 4 of 9 (44%) patients. RFLP studies were performed at 0.5, 1, 3, 6, 9, and 12 months post-BMT and then every 6 months, and showed a high probability of developing MC in the first 6 months after BMT followed by stabilization after 12 months. Cytogenetic analysis was less sensitive in detecting MC. Once MC was detected after BMT, the percentage of recipient cells increased very slowly over more than 3 years of follow- up, and no patient reverted to complete donor hematopoiesis (CDH). Thus, recipient and donor cells remained in a relative state of equilibrium for prolonged periods that seemed to favor recipient cells over donor cells. Patient's disease, remission status, or intensity of the transplant preparative regimen did not influence the subsequent development of mixed chimerism. Early immunologic reconstitution was the only factor that correlated with the subsequent chimeric status of the patients. The percentage and absolute number of T3 (CD3) and T4 (CD4) positive cells at day 14 after BMT were significantly higher in the patients who maintained CDH but NK cell reconstitution was similar in both groups, suggesting that early reconstitution with T cells may play a role in preventing recovery of recipient cells after BMT. GVHD was also associated with maintenance of CDH, but the probability of relapse, survival, and disease-free survival was identical in patients with MC and CDH.

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