scholarly journals Urine neopterin as a parameter of disease activity in patients with systemic lupus erythematosus: comparisons with serum sIL-2R and antibodies to dsDNA, erythrocyte sedimentation rate, and plasma C3, C4, and C3 degradation products.

1993 ◽  
Vol 52 (6) ◽  
pp. 429-435 ◽  
Author(s):  
K L Lim ◽  
A C Jones ◽  
N S Brown ◽  
R J Powell
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Lupus Erythematosus ◽  
Degradation Products ◽  
Systemic Lupus ◽  
Erythrocyte Sedimentation ◽  
Antibodies To Dsdna

scholarly journals Azathioprine Treatment in Systemic Lupus Erythematosus: A Double Edged Sword

2020 ◽  
Vol 14 (2) ◽  
Author(s):  
Jia XIA ◽  
Xiao SU ◽  
Wei-wei CHEN ◽  
Li-qun HE
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Oral Ulceration ◽  
Erythrocyte Sedimentation ◽  
Azathioprine Treatment ◽  
Severe Pancytopenia ◽  
Low Dosage

Extremely severe pancytopenia induced by low dosage of azathioprine in systemic lupus erythematosus patients is rare. A 40-year-old Chinese female was diagnosed with systemic lupus erythematosus. She suffered worse erythema, oral ulceration, raised erythrocyte sedimentation rate and high anti-dsDNA in August 2013. Then she was initiated on oral azathioprine 50mg/d and extremely severe pancytopenia was seen in September 2013. She was recovered by a series of treatments. Regular monitoring of blood counts is highly recommended to reduce the possible serious myelosuppression induced by azathioprine.

scholarly journals The ratio of erythrocyte sedimentation rate to C-reactive protein is useful in distinguishing infection from flare in systemic lupus erythematosus patients presenting with fever

Lupus ◽  
2018 ◽  
Vol 27 (7) ◽  
pp. 1123-1129 ◽  
Author(s):  
E Littlejohn ◽  
W Marder ◽  
E Lewis ◽  
S Francis ◽  
J Jackish ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Lupus Erythematosus ◽  
Laboratory Data ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Background Both C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can be elevated in systemic lupus erythematosus (SLE) flare and infection, and are therefore of limited utility for distinguishing between the two conditions in febrile SLE patients. Methods A medical records review of hospitalizations (1997–2006) of SLE patients in the Michigan Lupus Cohort was performed. Eligible hospitalizations were those in which patients presented with a temperature of >100.3°F or with subjective fevers as a presenting complaint at admission. Detailed demographic, clinical, and laboratory data were collected. Multivariable logistic regression was used to examine the associations between ESR and CRP and the outcome of flare vs infection, adjusted for confounders. Results Among 557 SLE patients screened, there were 53 eligible hospitalizations (28 flares and 25 infections). Each unit increase in the ratio of ESR:CRP was associated with a 17% increase in the odds of fever being attributable to SLE flare compared to infection (OR 1.17, 95% CI 1.04, 1.31; p = 0.009), when adjusted for white blood cell count, SLE duration, sex, race, and age. ESR and CRP were not individually associated with flare vs infection when modeled with their ratio. Conclusions The ratio of ESR:CRP may provide diagnostic value beyond individual ESR and CRP levels in distinguishing flare vs infection in SLE patients presenting with fever.

scholarly journals Relationship of profiles of antinuclear antibodies and cytokines in systemic lupus erythematosus

2019 ◽  
Vol 3 (22) ◽  
pp. 37-42
Author(s):  
E. N. Aleksandrova ◽  
A. A. Novikov ◽  
Zh. G. Verizhnikova ◽  
T. A. Panafidina ◽  
G. V. Lukina
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Systemic Autoimmune Disease ◽  
Systemic Lupus ◽  
Gm Csf ◽  
Healthy Donors ◽  
Relationship Of ◽  
Antibodies To Dsdna

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by pathological activation of the innate and acquired immune response, the formation of antinuclear antibodies (ANA), and dysregulation of cytokine production. Objective: to study the relationship of ANA and cytokine profiles in patients with SLE using multiplex immune analysis (MIA) of these biomarkers. We examined 94 patients with SLE (SLICC diagnosis criteria, 2012) and 28 healthy donors. Profiles of ANA and cytokines in blood serum were determined on the basis of suspension microarray technology xMAP. In SLE, antibodies to dsDNA (52.1 %), nucleosomes (54.3 %) and SS-A/Ro (37.2 %), less often to Sm (28.7 %), RibP (14, 9 %), RNP-70 (13.8 %) and SS-B/La (11.7 %). Disease activity (SLEDAI-2K) positively correlated with the concentration of antibodies to dsDNA (r = 0.6), nucleosomes (r = 0.7), Sm (r = 0.4) and RibP (r = 0.3) (p < 0.05). In the sera of patients with SLE, an increase in the levels of IL-4, -6, -8, -12, GM-CSF, MCP-1, MIP-1β, RANTES and a decrease in the content of IL-1β, IL-1ra, IL-2, IL-9, IL-10, eotaxin, G-CSF, IFN-γ, MIP-1α, TNF-α, FGF, PDGF-BB, VEGF compared to donors (p < 0.05). An increase in the concentration of IP-10 and MCP-1 was associated with high disease activity (r = 0.4; r = 0.3; p < 0.05), hyperproduction of antibodies to dsDNA (r = 0.3), nucleosomes (r = 0.5), Sm (r = 0.5), SS-B/La (r = 0.3), RibP (r = 0.4) (p < 0.05) and antibodies to Sm (r = 0.3), SS-B/La (r = 0.3), RibP (r = 0.3) (p < 0.05), respectively.Conclusion: the formation of ANA and high activity of SLE are associated with the overexpression of chemokines IP-10 and MCP-1 induced by IFN. 

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