High-sensitivity C-reactive protein and erythrocyte sedimentation rate in systemic lupus erythematosus

Lupus ◽  
2011 ◽  
Vol 20 (6) ◽  
pp. 588-597 ◽  
Author(s):  
N Firooz ◽  
DA Albert ◽  
DJ Wallace ◽  
M Ishimori ◽  
D Berel ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Lupus Erythematosus ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

scholarly journals The ratio of erythrocyte sedimentation rate to C-reactive protein is useful in distinguishing infection from flare in systemic lupus erythematosus patients presenting with fever

Lupus ◽  
2018 ◽  
Vol 27 (7) ◽  
pp. 1123-1129 ◽  
Author(s):  
E Littlejohn ◽  
W Marder ◽  
E Lewis ◽  
S Francis ◽  
J Jackish ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Lupus Erythematosus ◽  
Laboratory Data ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Background Both C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) can be elevated in systemic lupus erythematosus (SLE) flare and infection, and are therefore of limited utility for distinguishing between the two conditions in febrile SLE patients. Methods A medical records review of hospitalizations (1997–2006) of SLE patients in the Michigan Lupus Cohort was performed. Eligible hospitalizations were those in which patients presented with a temperature of >100.3°F or with subjective fevers as a presenting complaint at admission. Detailed demographic, clinical, and laboratory data were collected. Multivariable logistic regression was used to examine the associations between ESR and CRP and the outcome of flare vs infection, adjusted for confounders. Results Among 557 SLE patients screened, there were 53 eligible hospitalizations (28 flares and 25 infections). Each unit increase in the ratio of ESR:CRP was associated with a 17% increase in the odds of fever being attributable to SLE flare compared to infection (OR 1.17, 95% CI 1.04, 1.31; p = 0.009), when adjusted for white blood cell count, SLE duration, sex, race, and age. ESR and CRP were not individually associated with flare vs infection when modeled with their ratio. Conclusions The ratio of ESR:CRP may provide diagnostic value beyond individual ESR and CRP levels in distinguishing flare vs infection in SLE patients presenting with fever.

scholarly journals MODULASI SEL PUNCA MESENKIMAL DALAM MENURUNKAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SEBAGAI TERAPI NEFRITIS LUPUS

Biomedika ◽  
2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Indah Putri Maharani ◽  
Zainal Arifin Adnan ◽  
Arief Nurudhin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Systemic Lupus ◽  
Control Group Design ◽  
Group Design ◽  
Reactive Protein ◽  
Post Test

Systemic Lupus Erythematosus merupakan penyakit inflamasi autoimun kronis dengan gambaran klinis luas dan perjalanan penyakit beragam. Pemberian pristan intraperitoneal dapat menginduksi lupus pada mencit. Secretome sel punca mesenkimal bekerja secara parakrin memberikan efek antinflamasi dan imunomodulasi antara lain mensupresi sel T dan sel B autoreaktif. High Sensitivity C-Reactive Protein (hsCRP) terkait dengan patogenesis SLE dan selaras dengan aktifitas penyakit.Tujuan Penelitian adalah untuk mengetahui pengaruh secretome sel punca mesenkimal terhadap kadar hsCRP pada mencit model lupus dengan induksi pristan. Desain penelitian adalah eksperimental dengan randomisasi, post test only control group design, sampel 21 ekor mencit betina Mus Musculus galur Balb/C, dibagi 3 kelompok yaitu kelompok kontrol (injeksi intraperitoneal NaCl 0,9% 0,5 ml), kelompok perlakuan (injeksi pristan intraperitoneal 0,5 ml) dan kelompok terapi (injeksi intraperitoneal pristan 0,5 ml dan secretome 0,45 ml). Penelitian dilakukan selama 3 minggu, secretome diberikan pada akhir penelitian. Sesudah perlakuan dinilai kadar hsCRP secara ELISA. Analisis statistik menggunakan SPSS 22 for windows dengan uji Kruskal-Wallis dilanjutkan Mann-Whitney U test. P bermakna jika p<0,05. Hasil penelitian menunjukkan bahwa rata-rata kadar hsCRP pada ketiga kelompok yaitu kontrol 440.68(110.08-564.29) ng/ mL; perlakuan (pristan) 2964.26(601.13-3926.10) ng/mL; terapi pristan+secretome) 506.93(207.62-1473.46) ng/mL, dengan kemaknaan p=0.008. Terdapat perbedaan bermakna kadar hsCRP antara kelompok pristan vs pristan+secretome (2457.33 ng/mL; p=0.047). Secretome sel punca mesenkimal mampu menurunkan kadar hsCRP pada mencit model lupus dengan induksi pristan.Kata Kunci: High Sensitivity C-Reactive Protein, Nefritis lupus, Secretome

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