scholarly journals Subcutaneous fat necrosis of the newborn

2019 ◽  
Vol 12 (12) ◽  
pp. e231458 ◽  
Author(s):  
Niamh O' Brien ◽  
Breda Hayes
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Hand Preference ◽  
Skin Lesions ◽  
Term Infant ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Motor Delay ◽  
Full Resolution ◽  
Outcome Information

A term infant developed subcutaneous fat necrosis of the newborn (SFNN) 17 days following completion of therapeutic hypothermia for hypoxic ischaemic encephalopathy. Initial calcium was normal, however hypercalcaemia requiring hyperhydration and furosemide developed at 4 weeks. Parathyroid hormone and vitamin D were suppressed. At 13 months, she remains on low calcium formula, and has gross motor delay, central hypotonia and early hand preference. Review of 102 articles yielded 119 SFNN cases. Asphyxia was reported in 78%. Twenty-one per cent had hypoglycaemia. Twenty per cent underwent therapeutic hypothermia. Median onset of skin lesions was day 6 (range: 1–70), with a median duration of 62 days (range: 14–390). Hypercalcaemia developed in 53% (median onset day 28, range: 1–210). Fifty-two per cent of hypercalcaemia was asymptomatic. Outcome information was provided in 106/119 cases; 87% reported a full resolution. Persistent calcinosis was present in 6%. Babies treated with therapeutic hypothermia should be closely monitored for SFNN, and development of hypercalcaemia.

Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates

PEDIATRICS ◽  
2011 ◽  
Vol 128 (2) ◽  
pp. e450-e452 ◽  
Author(s):  
B. Strohm ◽  
A. Hobson ◽  
P. Brocklehurst ◽  
A. D. Edwards ◽  
D. Azzopardi ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

Subcutaneous Fat Necrosis in a Newborn after Brief Therapeutic Hypothermia: Ultrasonographic Examination

2014 ◽  
Vol 32 (3) ◽  
pp. 427-429 ◽  
Author(s):  
Linda Tognetti ◽  
Georgios Filippou ◽  
Sara Bertrando ◽  
Valentina Picerno ◽  
Giuseppe Buonocore ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Ultrasonographic Examination

Haematoma complicating subcutaneous fat necrosis of the newborn: a rare complication following therapeutic hypothermia

2020 ◽  
Vol 13 (6) ◽  
pp. e234360
Author(s):  
Elhaytham Omar Sanad Elsayed ◽  
Kamran Yusuf ◽  
Frankie O G Fraulin ◽  
Prashanth Murthy
Keyword(s):  
Therapeutic Hypothermia ◽  
Neonatal Intensive Care ◽  
Rare Complication ◽  
Subcutaneous Fat ◽  
Meconium Aspiration Syndrome ◽  
Large For Gestational Age ◽  
Unusual Complication ◽  
Skin Defect ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

A term, large for gestational age male newborn, was admitted to the neonatal intensive care unit with meconium aspiration syndrome and severe hypoxic-ischaemic encephalopathy. The baby was treated with therapeutic hypothermia using a total body cooling blanket. After 48 hours, the baby developed tender, indurated subcutaneous nodules consistent with subcutaneous fat necrosis (SCFN). The lesions started initially over the back but gradually spread to cover both shoulders, upper arms, chest area and both thighs. On day 19 of life, multiple small nodules on the back softened and coalesced to form one sizeable fluctuant swelling over the thoracolumbar area. Over a few hours, the swelling rapidly progressed to a large, tense mass with sloughing of the gangrenous overlying skin. This unusual complication of SCFN required surgical intervention for evacuation and debridement of the haematoma followed by graft repair of the skin defect.

Is Therapeutic Hypothermia Real Cause of Subcutaneous Fat Necrosis in Newborns?

2012 ◽  
Vol 80 (4) ◽  
pp. 355-356
Author(s):  
Nilay Hakan ◽  
Mustafa Aydin ◽  
Ayşegül Zenciroğlu ◽  
Sara Erol ◽  
Nurullah Okumuş
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

Occult Massive Visceral Fat Necrosis Following Therapeutic Hypothermia for Neonatal Encephalopathy

2017 ◽  
Vol 21 (5) ◽  
pp. 502-506
Author(s):  
Salwa Khedr ◽  
Anna Piskorski ◽  
Adrienne R Bingham ◽  
Justin Goldstein ◽  
Abbot R Laptook ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Neurodevelopmental Outcome ◽  
Pulmonary Artery Hypertension ◽  
Whole Body ◽  
Common Side Effect ◽  
Close Monitoring ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis

Therapeutic hypothermia (head or whole-body cooling) improves survival and neurodevelopmental outcome in term newborns with moderate-to-severe encephalopathy. Hypothermia treatment is well tolerated; the most common side effect is thrombocytopenia. In about 1% of infants, focal subcutaneous fat necrosis has been reported. We describe a case of clinically unsuspected massive visceral fat necrosis in a term infant with Apgar score 0 at 1 min (“resuscitated apparently stillborn” infant) who was treated with therapeutic hypothermia for 72 h and expired on the 25th day of life following a neonatal course complicated by severe encephalopathy, pulmonary artery hypertension, persistent thrombocytopenia, hypoglycemia, and severe basal ganglia-thalamic abnormalities on magnetic resonance imaging. Postmortem examination revealed extensive visceral (brown) fat necrosis, involving thoracic, abdominal, and retroperitoneal adipose tissue, with distinctive sparing of the subcutaneous (white) fat. The fulminant—yet clinically occult—visceral fat necrosis seen in this case suggests that (lesser degrees of) fat necrosis may go unrecognized in hypoxic-ischemic newborns, especially in those treated with hypothermia, and underscores the importance of close monitoring of encephalopathic newborns both in the short and long terms for complications of fat necrosis (hypercalcemia and nephrocalcinosis).

scholarly journals Nefrocalcinose e Necrose Gorda do Tecido Celular Subcutâneo

2014 ◽  
Vol 28 (1) ◽  
pp. 119 ◽  
Author(s):  
Cláudia Gomes ◽  
Luísa Lobo ◽  
António Siborro Azevedo ◽  
Carla Simão
Keyword(s):  
Chronic Kidney Disease ◽  
Subcutaneous Fat ◽  
Skin Lesions ◽  
Urinary Calcium ◽  
Self Healing ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Prompt Treatment ◽  
Infant Newborn ◽  
Serial Serum

<p>Subcutaneous fat necrosis of the newborn is an uncommon, transient and self-healing panniculits. This entity generally follows an uncomplicated course, however there are rare and important complications. The authors present a case of a newborn with subcutaneous fat necrosis complicated by hypercalcemia and nephrocalcinosis. The pathogenesis of hypercalcemia is not fully understood and the nephrocalcinosis can evolve to chronic kidney disease. Clinicians should be aware of subcutaneous fat necrosis as a possible risk<br />factor for hypercalcemia and patients should have serial serum and urinary calcium determinations for up to 6 months after the appearance of the skin lesions. The early diagnosis and prompt treatment of hypercalcemia are essential to prevent severe complications.<br /><strong>Keywords:</strong> Hypercalcemia; Fat Necrosis; Infant, Newborn; Nephrocalcinosis; Subcutaneous Fat. </p>

scholarly journals Subcutaneous Fat Necrosis of the Newborn: A Case Report of a Term Infant Presenting with Malaise and Fever at Age of 9 Weeks

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ayuk Adaeze Chikaodinaka ◽  
Anikene Chukwuemeka Jude
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Fat ◽  
Late Complications ◽  
Term Infant ◽  
Rare Entity ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Common Diagnosis ◽  
Prompt Diagnosis

Background. Subcutaneous fat necrosis (SFN) is a rare, temporary, self-limited pathology affecting adipose tissue of full-term or postmature neonates. It is a rare entity especially in Nigeria and usually occurs in the first weeks following a complicated delivery. Because it is not very common, diagnosis is easily missed. It may resolve spontaneously without sequelae but patients need to be followed up because of development of late complications especially hypercalcemia. We report a case of SFN of the newborn noted within one week of birth and highlight the need for proper prompt diagnosis and the need for follow-up to assess possible complications.

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