Solitary extramedullary plasmacytoma of the larynx: a rare cause of dysphonia

2020 ◽  
Vol 13 (9) ◽  
pp. e234478
Author(s):  
Hannes Hermann Brandt ◽  
Steffi Johanna Brockmeier ◽  
Nora Tetter
Keyword(s):  
Plasma Cell ◽  
Progressive Disease ◽  
Thyroid Cartilage ◽  
Extramedullary Plasmacytoma ◽  
Secondary Amyloidosis ◽  
Systemic Involvement ◽  
Amyloid Deposits ◽  
History Of ◽  
Solitary Extramedullary Plasmacytoma

Solitary extramedullary plasmacytoma (SEP) of the larynx is a rare haematological malignancy and an infrequent cause of persisting dysphonia. We present the case of a 54-year-old woman with a long-standing history of dysphonia. While clinical examination showed a rather inconspicuous prominent right vestibular fold, an MRI revealed a laryngeal mass with erosion of the thyroid cartilage. A biopsy taken during rigid endoscopy demonstrated plasma cell infiltration with light chain restriction amidst amyloid deposits. After exclusion of systemic involvement, the diagnosis of an SEP of the larynx with secondary amyloidosis was made. The patient received primary radiation therapy. Another biopsy taken 3 months after the end of therapy did not show any signs of ongoing neoplastic plasma cell disease. The patient was therefore considered to be in remission. She is currently receiving regular follow-up and has not shown signs of persistent or progressive disease for the past 18 months.

Extramedullary Plasmacytoma of The Frontal Sinus: A Case Report

FACE ◽  
2021 ◽  
pp. 273250162110536
Author(s):  
Joshua Harrison ◽  
Samantha Marley ◽  
Shawhin Shahriari ◽  
Christian Bowers ◽  
Anil Shetty
Keyword(s):  
Frontal Sinus ◽  
Surgical Excision ◽  
Extramedullary Plasmacytoma ◽  
High Rate ◽  
Solitary Plasmacytoma ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
History Of

We report a rare case of an extramedullary plasmacytoma (EMP) in the frontal sinus with an indolent clinical presentation. Although a history of trauma was absent, the initial diagnosis was a mucocele, based on the radiological findings. Upon surgical excision, the patient was found to have an EMP. EMP, a form of solitary plasmacytoma, has a significantly high rate of conversion to multiple myeloma. This mandates long-term follow-up, even after successful radiotherapy and/or resection. While radiation therapy is generally considered a first line treatment for EMP, surgical intervention may provide optimal treatment in complicated cases. This case presentation highlights the prognosis of patients diagnosed with EMP.

Primary Plasmacytoma of the Breast

2001 ◽  
Vol 125 (8) ◽  
pp. 1078-1080 ◽  
Author(s):  
Annarosaria De Chiara ◽  
Simona Losito ◽  
Luigi Terracciano ◽  
Raimondo Di Giacomo ◽  
Giancarla Iaccarino ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Differential Diagnosis ◽  
Correct Diagnosis ◽  
Extramedullary Plasmacytoma ◽  
Frozen Sections ◽  
Solitary Extramedullary Plasmacytoma ◽  
Extramedullary Plasmacytomas

Abstract We describe a solitary extramedullary plasmacytoma of the breast in a 37-year-old woman. No other involvement was detected in the bone marrow or in any other site during a 15-month follow-up period. Extramedullary plasmacytomas of the breast are extremely rare, especially those that are not associated with multiple myeloma. We review the histologic features of the previously reported cases with an emphasis on differential diagnosis and the difficulties encountered in arriving at the correct diagnosis in frozen sections.

scholarly journals Extramedullar Plasmacytoma Arising from the Nasal Septum

2005 ◽  
Vol 84 (11) ◽  
pp. 720-722 ◽  
Author(s):  
Byoung J. Baek ◽  
Seong W. Kim ◽  
Hoon Park ◽  
Jin K. Park ◽  
Kyung Y. Han ◽  
...  
Keyword(s):  
Nasal Septum ◽  
Biopsy Specimen ◽  
Extramedullary Plasmacytoma ◽  
Screening Tests ◽  
Bence Jones Protein ◽  
Light Chain Type ◽  
History Of ◽  
Chain Type ◽  
Rule Out

We report a rare case of extramedullary plasmacytoma of the nasal septum in a 65-year-old woman. She presented with a 2-month history of left-sided nasal obstruction and intermittent blood-tinged nasal crusting. Nasal endoscopy revealed that a dark-red mass had arisen from the nasal septum; no evidence of invasion to adjacent tissues was seen. A biopsy specimen was diagnosed as a plasmacytoma (kappa light chain—type). Serum and urine electrophoresis failed to detect any myeloma component or Bence Jones protein. All other screening tests to rule out multiple myeloma were negative. These findings confirmed the diagnosis of extramedullary plasmacytoma. The mass was completely removed via an endoscopic approach. No recurrence was noted at the 2-year follow-up.

scholarly journals Extramedullary Plasmacytoma Mimicking Pancreatic Cancer: An Unusual Presentation

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Daniela Sciancalepore ◽  
Sergio Musci ◽  
Maria Rosaria Fracella ◽  
Grazia D’Alesio ◽  
Azzurra Sportelli ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cell ◽  
Extramedullary Plasmacytoma ◽  
Endocrine Glands ◽  
Autologous Transplant ◽  
History Of ◽  
Remission Phase ◽  
Timing Of Onset ◽  
Gallbladder Fossa

Multiple myeloma is a plasma cell tumor that homes to and expands in the bone marrow and that, despite the new available drugs, remains incurable. Extramedullary plasmacytoma is a not frequent manifestation during the natural history of multiple myeloma and is frequently associated with plasma cell bone marrow infiltration. The most common locations for an EMP include the gastrointestinal tract, pleura, testis, skin, peritoneum, liver, endocrine glands, and lymph nodes. Primary involvement of the gallbladder fossa is exceedingly rare. In this report, we describe a patient with multiple myeloma who achieved a clinical and serological remission after autologous transplant but progressed rapidly at extramedullary site mimicking a second cancer (i.e., pancreatic or biliary cancer). In this case, the extramedullary localization was refractory to standard therapy, differently from bone marrow localization, but responded to lymphoma-like therapy. In this patient (i) the particular site of developing plasmacytoma is the gallbladder fossa, (ii) the timing of onset of this neoplasm is immediately after autologous transplant, and (iii) its disjunction from primary myeloma is that it appears in clinical and serological remission phase which may be confounding during the diagnostic approach simulating a different tumor (solid tumor).

scholarly journals Strategy for the treatment and follow-up of sinonasal solitary extramedullary plasmacytoma: a case series

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Elena Cantone ◽  
Antonella Miriam Di Lullo ◽  
Luana Marano ◽  
Elia Guadagno ◽  
Gelsomina Mansueto ◽  
...  
Keyword(s):  
Case Series ◽  
Extramedullary Plasmacytoma ◽  
Solitary Extramedullary Plasmacytoma

scholarly journals Solitary Plasmacytoma of the Mesentery: A Systematic Clinician’s Diagnosis

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Georgia Mitropoulou ◽  
Adamantia Zizi-Sermpetzoglou ◽  
Hippokrates Moschouris ◽  
Athanasios Kountourogiannis ◽  
Despoina Myoteri ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Plasma Cells ◽  
Histopathological Examination ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Plasma Cell Neoplasm ◽  
Mesenteric Root ◽  
Laparoscopic Biopsy ◽  
Bone Marrow Plasma ◽  
Solitary Extramedullary Plasmacytoma

Introduction. Plasmacytoma is an uncommon plasma cell neoplasm and its localized form is solitary plasmacytoma of the bone and solitary extramedullary plasmacytoma. Solitary plasmacytoma of the mesentery is extremely rare, reported only in a handful of cases. Case Presentation. A 47-year-old man with nonspecific abdominal complains was found to have an ill-defined mass on his mesenteric root. Laparoscopic biopsy and stepwise histopathological examination revealed a mesenteric plasmacytoma, and extensive imaging and laboratory investigations led to the diagnosis of the solitary mesenteric plasmacytoma. The patient underwent definitive radiotherapy and remains under remission one year later. Discussion. Plasma cell dyscrasias include a variant of proliferative disease, characterized by clonal expansion of bone marrow plasma cells, producing a massive quantity of monoclonal immunoglobulin called paraprotein or M-protein. Solitary extramedullary plasmacytoma accounts for only 3–5% of all plasma cell neoplasms. Meticulous adherence to the established diagnostic criteria helps the clinician to set the correct, yet very unusual and unexpected diagnosis.

scholarly journals Solitary Extramedullary Plasmacytoma Presenting as Asymptomatic Palatal Erythroplakia: Report of a Case

2021 ◽  
Vol 18 (7) ◽  
pp. 3762
Author(s):  
Francesca Lalla ◽  
Alessandro Vinciguerra ◽  
Alessandra Lissoni ◽  
Gianluigi Arrigoni ◽  
Francesca Lira Luce ◽  
...  
Keyword(s):  
Plasma Cells ◽  
Excisional Biopsy ◽  
Extramedullary Plasmacytoma ◽  
Definitive Diagnosis ◽  
Solitary Plasmacytoma ◽  
Systemic Spread ◽  
Solitary Bone Plasmacytoma ◽  
Immunohistochemical Studies ◽  
Solitary Extramedullary Plasmacytoma

Solitary plasmacytoma (SP) is a rare malignant tumor of plasma cells with no systemic spread; however, when it disseminates and affects multiple skeletal sites, it is called multiple myeloma (MM). The etiology of solitary plasmacytoma is unknown, with two possible subtypes: solitary extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP). We present a case of EMP arising as asymptomatic erythroplakia of the palate, which is rarely described in the literature. The definitive diagnosis was obtained with immunohistochemical studies, after which the lesion was subjected to excisional biopsy. At present, after two years of close follow-up, the patient has shown no signs of relapse or conversion to MM. The uniqueness of the case highlights the possibility of an atypical EMP lesion in the head and neck, thus posing a diagnostic and therapeutic challenge for physicians.

scholarly journals Septal Nasal Extramedullary Plasmacytoma: A Rare Tumor in an Unusual Area

2020 ◽  
pp. 014556132091173
Author(s):  
Arianna Di Stadio ◽  
Massimo Ralli ◽  
Daniela Messineo ◽  
Giuseppe Ciancia ◽  
Annamaria Cascone ◽  
...  
Keyword(s):  
Nasal Septum ◽  
Rare Case ◽  
Extramedullary Plasmacytoma ◽  
Rare Tumor ◽  
Short Cycle ◽  
Systemic Involvement

We present an extreme rare case of extramedullary nasal plasmacitoma that arise from nasal septum. The mass surgically removed was analyzed by a pathologist who diagnosed an extramedullary nasal plasmacytoma. The patient did not present systemic involvement. A short cycle of radiotherapy was performed after the surgery. At 9-month follow-up, the patient is recurrence free.

scholarly journals SOLITARY PLASMACYTOMA

2017 ◽  
Vol 9 (1) ◽  
pp. e2017052 ◽  
Author(s):  
Sara Grammatico ◽  
Emilia Scalzulli ◽  
Maria Teresa Petrucci
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cells ◽  
Systemic Disease ◽  
Extramedullary Plasmacytoma ◽  
Bone Lesions ◽  
Solitary Plasmacytoma ◽  
Systemic Involvement ◽  
Number Of Patients ◽  
Solitary Bone Plasmacytoma ◽  
Solitary Extramedullary Plasmacytoma

Solitary plasmacytoma is a rare disease characterized by a localized proliferation of neoplastic monoclonal plasma cells, without evidence of systemic disease. It can be subdivided into solitary bone plasmacytoma, if the lesion originates in bone, or solitary extramedullary plasmacytoma, if the lesion involves a soft tissue. Incidence of solitary bone plasmacytoma is higher than solitary extramedullary plasmacytoma. Also prognosis is different: even if both forms respond well to treatment, overall survival and progression free survival of solitary bone plasmacytoma is poorer than solitary extramedullary plasmacytoma due to its higher rate of evolution in multiple myeloma. However, the recent advances in the diagnosis of multiple myeloma can better refine also the diagnosis of plasmacytoma. Flow cytometry studies and molecular analysis may reveal clonal plasma cells in the bone marrow; magnetic resonance imaging or 18 Fluorodeoxyglucose positron emission tomography could better define osteolytic bone lesions. A more precise exclusion of eventual occult systemic involvement can avoid cases of misdiagnosed multiple myeloma patients, that were previously considered solitary plasmacytoma and less treated, with an unavoidable poor prognosis.Due to the rarity of the disease, there is no uniform consensus about prognostic factors and treatment. Radiotherapy is the treatment of choice; however, some authors debates about the radiotherapy dose and the relationship with the response rate. Moreover, the role of surgery and chemotherapy is still under debate. Nevertheless, we must consider that the majority of studies include a small number of patients and analyze the efficacy of conventional chemotherapy; few cases are reported concerning the efficacy of novel agents.Keywords: solitary plasmacytoma; myeloma; radiotherapy; osteolytic lesions  

Primary Solitary Extramedullary Plasmacytoma Involving the True Vocal Cords in a Pregnant Woman

2013 ◽  
Vol 99 (1) ◽  
pp. e14-e18 ◽  
Author(s):  
Soumya Ghatak ◽  
Mainak Dutta ◽  
Indranath Kundu ◽  
Rajendra Prasad Ganguly
Keyword(s):  
Pregnant Woman ◽  
Subsequent Treatment ◽  
Extramedullary Plasmacytoma ◽  
Rare Entity ◽  
Vocal Cords ◽  
First Time ◽  
Solitary Extramedullary Plasmacytoma ◽  
Bence Jones Proteinuria ◽  
In Pregnancy

Primary solitary extramedullary plasmacytoma of the larynx involving the true vocal cords is an extremely rare entity. Extramedullary plasmacytoma has the potential to transform into multiple myeloma and mandates strict vigilance and routine follow-up. We describe such a case in a 29-year-old pregnant woman who presented with progressive hoarseness, dysphagia and intermittent respiratory difficulty. Fiberoptic laryngoscopy revealed a fleshy mass involving the posterior third of the true vocal cords, encroaching on the ventricle and false cords. Histopathology and immunohistochemistry revealed extramedullary plasmacytoma of a monoclonal nature. In spite of Bence Jones proteinuria and a rising serum β2-microglobulin level, a thorough search for metastasis and subsequent treatment with radiotherapy were delayed due to the patient's pregnancy. She is the youngest adult ever reported with primary solitary extramedullary plasmacytoma involving the true cords. Described for the first time in pregnancy, the relevant issues in management are highlighted.

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