scholarly journals Unusual cause of congenital hypothyroidism in a term infant

2021 ◽  
Vol 14 (2) ◽  
pp. e237930
Author(s):  
Hester Vlaardingerbroek
Keyword(s):  
Congenital Hypothyroidism ◽  
East Asian ◽  
Neurodevelopmental Outcome ◽  
Daily Basis ◽  
Term Infant ◽  
Pregnancy And Lactation ◽  
Transient Congenital Hypothyroidism ◽  
Dutch Family

Both insufficient and excessive maternal iodine consumption can result in congenital hypothyroidism. In East Asian cultures, seaweed is traditionally consumed in high quantities by peripartum women as it is thought to improve lactation. We present a case of transient congenital hypothyroidism due to maternal seaweed consumption at a daily basis during pregnancy and lactation in a Dutch family without Asian background. This case highlights that even in families of non-Asian background, high maternal intake of iodine-rich seaweed occurs and can result in transient or permanent hyperthyrotropinemia in the neonate with risk of impaired neurodevelopmental outcome if untreated.

scholarly journals Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria C. Opazo ◽  
Juan Carlos Rivera ◽  
Pablo A. Gonzalez ◽  
Susan M. Bueno ◽  
Alexis M. Kalergis ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Congenital Hypothyroidism ◽  
Gene Mutations ◽  
Genetic Variations ◽  
Hormone Deficiency ◽  
Iodide Transport ◽  
Transport Defect ◽  
Pregnancy And Lactation ◽  
Transient Congenital Hypothyroidism

Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant. Genetic variations on thyroid proteins that cause dyshormonogenic congenital hypothyroidism could in pregnant and breastfeeding women impair the delivery of thyroid hormones and iodine to the offspring. The review discusses maternal genetic variations in thyroid proteins that, in the context of pregnancy and/or breastfeeding, could trigger thyroid hormone deficiency or iodide transport defect that will affect the proper development of the offspring.

scholarly journals Diagnosis and Management of Central Congenital Hypothyroidism

2021 ◽  
Vol 12 ◽  
Author(s):  
Peter Lauffer ◽  
Nitash Zwaveling-Soonawala ◽  
Jolanda C. Naafs ◽  
Anita Boelen ◽  
A. S. Paul van Trotsenburg
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Congenital Hypothyroidism ◽  
Neonatal Period ◽  
Neurodevelopmental Outcome ◽  
Pituitary Hormone ◽  
Feeding Problems ◽  
Severe Condition ◽  
Diagnosis And Management ◽  
Prolonged Jaundice

Central congenital hypothyroidism (CH) is defined as thyroid hormone (TH) deficiency at birth due to insufficient stimulation by the pituitary of the thyroid gland. The incidence of central CH is currently estimated at around 1:13,000. Central CH may occur in isolation, but in the majority of cases (60%) it is part of combined pituitary hormone deficiencies (CPHD). In recent years several novel genetic causes of isolated central CH have been discovered (IGSF1, TBL1X, IRS4), and up to 90% of isolated central CH cases can be genetically explained. For CPHD the etiology usually remains unknown, although pituitary stalk interruption syndrome does seem to be the most common anatomic pituitary malformation associated with CPHD. Recent studies have shown that central CH is a more severe condition than previously thought, and that early detection and treatment leads to good neurodevelopmental outcome. However, in the neonatal period the clinical diagnosis is often missed despite hospital admission because of feeding problems, hypoglycemia and prolonged jaundice. This review provides an update on the etiology and prognosis of central CH, and a practical approach to diagnosis and management of this intriguing condition.

Impact of compliance to therapy of congenital hypothyroidism on the neurodevelopmental outcome in Sharkia Governorate

2017 ◽  
Vol 30 (1) ◽  
pp. 39
Author(s):  
WalaaS Mohamed ◽  
TaghreedM Farahat ◽  
EmanA Elshorbagy ◽  
NagwaN Hegazy
Keyword(s):  
Congenital Hypothyroidism ◽  
Neurodevelopmental Outcome

scholarly journals OUTCOME OF 3 SIBLINGS WITH ANTIBODY-MEDIATED TRANSIENT CONGENITAL HYPOTHYROIDISM

1993 ◽  
Vol 33 ◽  
pp. S92-S92
Author(s):  
D Pacaud ◽  
C Huot ◽  
A Gattereau ◽  
R S Brown ◽  
J Glorieux ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Transient Congenital Hypothyroidism

scholarly journals Transient Congenital Hypothyroidism Alters Gene Expression of Glucose Transporters and Impairs Glucose Sensing Apparatus in Young and Aged Offspring Rats

2017 ◽  
Vol 43 (6) ◽  
pp. 2338-2352 ◽  
Author(s):  
Hanieh Gholami ◽  
Sajad Jeddi ◽  
Azita Zadeh-Vakili ◽  
Khadije Farrokhfall ◽  
Fatemeh Rouhollah ◽  
...  
Keyword(s):  
Carbohydrate Metabolism ◽  
Congenital Hypothyroidism ◽  
Glucose Transporter ◽  
Glucose Transporters ◽  
Glucose Sensing ◽  
Hormone Deficiency ◽  
Gene Expressions ◽  
Glut4 Expression ◽  
Increased Risk ◽  
Transient Congenital Hypothyroidism

Background/Aims: Transient congenital hypothyroidism (TCH) could disturb carbohydrate metabolism in adulthood. Aging is associated with increased risk of type 2 diabetes. This study aims to address effects of TCH on mRNA expressions of glucose transporters (GLUTs) and glucokinase (GcK) in islets and insulin target tissues of aged offspring rats. Methods: The TCH group received water containing 0.025% 6-propyl-2-thiouracil during gestation. Offspring from control and TCH groups (n=6 in each group) were followed until month 19. Gene expressions of GLUTs and GcK were measured at months 3 and 19. Results: Compared to controls, aged TCH rats had higher GLUT4 expression in heart (4.88 fold) and soleus (6.91 fold), while expression was lower in epididymal fat (12%). In TCH rats, GLUT2 and GcK expressions in islets were lower in young (12% and 10%, respectively) and higher in aged (10.85 and 8.42 fold, respectively) rats. In addition, liver GLUT2 and GcK expressions were higher in young (13.11 and 21.15 fold, respectively) and lower in aged rats (44% and 5%, respectively). Conclusion: Thyroid hormone deficiency during fetal period impaired glucose sensing apparatus and changed glucose transporter expression in insulin-sensitive tissues of aged offspring rats. These changes may contribute to impaired carbohydrate metabolism.

scholarly journals Treatment and follow-up of children with transient congenital hypothyroidism

2005 ◽  
Vol 6 (12) ◽  
pp. 1206-1209 ◽  
Author(s):  
Ru-lai Yang ◽  
Zhi-wei Zhu ◽  
Xue-lian Zhou ◽  
Zheng-yan Zhao
Keyword(s):  
Congenital Hypothyroidism ◽  
Transient Congenital Hypothyroidism
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