Unique case of glandular odontogenic cyst showing mucoepidermoid carcinoma-like islands in cystic wall

2021 ◽  
Vol 14 (2) ◽  
pp. e239362
Author(s):  
Harpreet Kaur ◽  
Deepika Mishra ◽  
Rahul Yadav
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Final Diagnosis ◽  
Odontogenic Cyst ◽  
Odontogenic Cysts ◽  
Low Grade ◽  
Male Predominance ◽  
Glandular Odontogenic Cyst ◽  
Jaw Cyst ◽  
Intermediate Cells ◽  
Anterior Mandible

Glandular odontogenic cyst (GOC) is a very rare jaw cyst accounting for 0.2% of all odontogenic cysts. It presents usually in adults with a slight male predominance. It shows radiological, histopathological and even immunohistochemical overlap with low grade intraosseous mucoepidermoid carcinoma (MEC) but their distinction is crucial. A 57-year-old woman with bilocular radiolucency in the anterior mandible crossing the midline is described here. Microscopy features were consistent with glandular odontogenic cyst but multiple MEC-like islands were seen in the capsule, creating a diagnostic head trip with low grade intraosseous MEC. However, the absence of cellular atypia and epidermoid and intermediate cells led to a final diagnosis of GOC, with close follow-up of the patient recommended. This rare finding shows the relation between GOC and MEC or the origin of MEC from GOC.

Glandular Odontogenic Cyst – a Case Report

Dental Update ◽  
2020 ◽  
Vol 47 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Manouchehri Shaadi ◽  
Amini Ali
Keyword(s):  
Case Report ◽  
Odontogenic Cyst ◽  
Treatment Modalities ◽  
Occurrence Rate ◽  
Odontogenic Cysts ◽  
Glandular Odontogenic Cyst ◽  
Wide Range ◽  
Odontogenic Origin ◽  
The Right ◽  
Anterior Mandible

Abstract: A Glandular Odontogenic Cyst (GOC) is a rare developmental cyst of odontogenic origin. Occurrence rate is low, with less than 150 cases reported in the literature thus far. 1 GOCs can be misdiagnosed due to clinicopathological similarities to other odontogenic cysts, including those of a benign and malignant nature. A wide range of ages can be affected, with a mean age of 45.7. 2 The most commonly affected site appears to be the anterior mandible. An unusual presentation of a GOC affecting the right posterior mandible of a 42-year-old male is reported. CPD/Clinical Relevance: This article highlights the importance of appropriate special investigations for a glandular odontogenic keratocyst and treatment modalities.

Glandular Odontogenic Cyst Mimicker: A Novel Entity

2016 ◽  
Vol 6 (2) ◽  
pp. 145-148
Author(s):  
Kehkashan E Azmi
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Dentigerous Cyst ◽  
Odontogenic Cyst ◽  
Biological Behavior ◽  
Low Grade ◽  
Glandular Odontogenic Cyst ◽  
Transformation Potential ◽  
Collaborative Efforts ◽  
Lateral Periodontal Cyst ◽  
Maxillary Region

ABSTRACT Glandular odontogenic cyst (GOC) is an uncommon developmental odontogenic cyst of jaws with a frequency of approximately 0.2%. Because of its aggressive biological behavior including its malignant transformation potential, recently collaborative efforts by few researchers have laid down certain histopathological criteria segregating it from its mimickers which include dentigerous cyst, lateral periodontal cyst (LPC), or botryoid cyst, radicular cyst, and central low-grade mucoepidermoid carcinoma. Therefore, cautious histopathological evaluation is necessary of GOC mimickers in order to prevent its overdiagnosis. Here, we present a case of GOC mimicker in a 12-year-old male patient in left maxillary region. How to cite this article Azmi KE, Patel S, Pathak J, Swain N. Glandular Odontogenic Cyst Mimicker: A Novel Entity. J Contemp Dent 2016;6(2):145-148.

scholarly journals Central Mucoepidermoid Carcinoma Arising Directly From a Glandular Odontogenic Cyst of the Mandible: A Case Report

2021 ◽  
Author(s):  
Satoshi Maruyama ◽  
Taisuke Mori ◽  
Manabu Yamazaki ◽  
Tatsuya Abé ◽  
Eijitsu Ryo ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Salivary Gland Tumor ◽  
Third Molar ◽  
Odontogenic Cyst ◽  
Glandular Odontogenic Cyst ◽  
Old Japanese ◽  
Central Mucoepidermoid Carcinoma ◽  
Intermediate Cells ◽  
The Right

Abstract BackgroundCentral mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jaw bone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. Case presentationA 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The immunohistochemistry for cytokeratin (CK) profile results demonstrated that while both central MEC and GOC expressed CKs 7, 14, 18, and 19, interestingly CK13 was only expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both MEC and GOC components. ConclusionsOur case suggests that central MEC and GOC may be in the same spectrum of diseases caused by rearrangement of the MAML-2 gene. At the same time, the expression profile of CK13 was completely different in both central MEC and GOC. This also suggests that central MEC is a distinct tumor from GOC. Thus, we demonstrated the rare case that central MEC may have originated directly from the GOC.

scholarly journals Central mucoepidermoid carcinoma arising directly from a glandular odontogenic cyst of the mandible: a case report

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Satoshi Maruyama ◽  
Taisuke Mori ◽  
Manabu Yamazaki ◽  
Tatsuya Abé ◽  
Eijitsu Ryo ◽  
...  
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Rare Case ◽  
Salivary Gland Tumor ◽  
Third Molar ◽  
Odontogenic Cyst ◽  
Glandular Odontogenic Cyst ◽  
Old Japanese ◽  
Central Mucoepidermoid Carcinoma ◽  
Intermediate Cells ◽  
The Right

Abstract Background Central mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jawbone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible. Case presentation A 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical findings of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The results from the immunohistochemistry for cytokeratin (CK) profiling demonstrated that, while both central MEC and GOC expressed CKs 7, 14, 18, and 19, CK13 was interestingly exclusively expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both the MEC and GOC components. Conclusions Our case suggests that central MEC and GOC may be in the same spectrum of diseases caused by the rearrangement of the MAML-2 gene. However, given that the expression profile of CK13 was completely different between central MEC and GOC, they can be considered as separate tumors. Overall, we demonstrated a rare case in which central MEC may have originated directly from the GOC.

LESION IN THE ANTERIOR MANDIBLE: CASE REPORT OF A GLANDULAR ODONTOGENIC CYST IN AN ELDERLY PATIENT

2020 ◽  
Vol 129 (1) ◽  
pp. e62
Author(s):  
ARTHUR PIAS SALGUEIRO ◽  
JULIANA ROMANINI ◽  
ISADORA FOLLAK DE SOUZA ◽  
LAURA CAMPOS HILDEBRAND ◽  
FERNANDA VISIOLI ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Odontogenic Cyst ◽  
Glandular Odontogenic Cyst ◽  
Anterior Mandible

scholarly journals Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features

2019 ◽  
Vol 12 (4) ◽  
pp. e224612
Author(s):  
Nicholas B Abt ◽  
Matthew E Lawler ◽  
Joseph Zacharias ◽  
Edward T Lahey
Keyword(s):  
Mucoepidermoid Carcinoma ◽  
Malignant Neoplasm ◽  
Inflammatory Lesion ◽  
Advancement Flap ◽  
Careful Examination ◽  
Iliac Crest Bone Graft ◽  
Odontogenic Cysts ◽  
Low Grade ◽  
Malignant Tumours ◽  
Second Molar

Mucoepidermoid carcinoma (MEC) can be rarely found as a primarily intraosseous lesion and mistaken for other intraosseous or odontogenic pathology. A 65-year-old man had a poorly defined radiolucency distal to the left mandibular second molar root. Periapical radiographs demonstrated a minor radiolucency from 2.5 years prior. An oral and maxillofacial surgeon felt the radiolucency represented periodontal disease, extracting tooth #18. The differential diagnosis of mixed radiolucent/radio-opaque mandibular lesions includes: (1) fibro-osseous lesion, (2) odontogenic and non-odontogenic cyst, (3) infection and inflammatory lesion, or (4) benign or malignant neoplasm (odontogenic, non-odontogenic, or metastatic). Histological analysis revealed low-grade MEC. A composite resection was performed with a 1 cm margin from first molar to ascending ramus. A buccal fat pad advancement flap covered the defect with an iliac crest bone graft placed later for a resulting osseous defect. Careful examination and diagnostic work-up for odontogenic cysts should be provided as they may harbour malignant tumours.

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