Robot-assisted laparoscopic hysterectomy for endometrial cancer in a patient with Herlyn-Werner-Wunderlich syndrome

2021 ◽  
Vol 14 (5) ◽  
pp. e240001
Author(s):  
Misa Kobayashi ◽  
Hiroharu Kobayashi ◽  
Satoru Nakayama ◽  
Hiroshi Adachi
Keyword(s):  
Endometrial Cancer ◽  
Laparoscopic Hysterectomy ◽  
Pelvic Lymphadenectomy ◽  
Lateral Side ◽  
Robot Assisted ◽  
Duct Cyst ◽  
Vaginal Septum ◽  
History Of ◽  
Delay Of Treatment ◽  
The Right

Herlyn-Werner-Wunderlich syndrome, a rare Mullerian duct anomaly, includes a triad of uterine didelphys, obstructed haemivagina and ipsilateral renal agenesis. A 58-year-old woman with Herlyn-Werner-Wunderlich syndrome, reported of recurrent genital bleeding for 9 years, was finally diagnosed with endometrial cancer. She had a history of vaginal septum resection and nephrectomy of atrophic right kidney. MRI demonstrated uterine didelphys, a tumour filling the left uterus and a cyst on the right lateral side of the uterus. Robot-assisted hysterectomy, including bilateral salpingo-oophorectomy and pelvic lymphadenectomy, was performed. As the cyst communicated with the right cervix, but not with the urinary tract, a Gartner duct cyst was diagnosed. Uncertain diagnosis and delay of treatment in endometrial cancer may occur in patients with Herlyn-Werner-Wunderlich syndrome. We should preoperatively fully evaluate the anatomy of the uterus and surrounding tissues and plan surgical procedures, especially in patients with urogenital malformations.

Chronic Postoperative Pain After Robot-Assisted Laparoscopic Hysterectomy for Endometrial Cancer

2019 ◽  
Vol 35 (3) ◽  
pp. 140-146 ◽  
Author(s):  
Søren Lunde ◽  
Kristian Kjær Petersen ◽  
Pirathiv Kugathasan ◽  
Lars Arendt-Nielsen ◽  
Erik Søgaard-Andersen
Keyword(s):  
Endometrial Cancer ◽  
Postoperative Pain ◽  
Laparoscopic Hysterectomy ◽  
Chronic Postoperative Pain ◽  
Robot Assisted

Robot-assisted laparoscopic hysterectomy is superior for endometrial cancer in the morbidly obese

2011 ◽  
Vol 120 ◽  
pp. S130-S131
Author(s):  
A. Maddock ◽  
R. Pierre ◽  
T. Ford ◽  
D. Kredentser ◽  
T. McElrath ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Laparoscopic Hysterectomy ◽  
Morbidly Obese ◽  
Robot Assisted

scholarly journals Case Report: Synchronous primary malignancy including the breast and endometrium

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1502
Author(s):  
Elham Sadat Banimostafavi ◽  
Sepideh Tayebi ◽  
Maryam Tayebi ◽  
Fatemeh Montazer
Keyword(s):  
Endometrial Cancer ◽  
Rare Event ◽  
Uterine Wall ◽  
Pelvic Cavity ◽  
Primary Malignancy ◽  
Tissue Mass ◽  
Her Family ◽  
History Of ◽  
Abnormal Vaginal Bleeding ◽  
The Right

Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type.  In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.

Sentinel node detection in a patient with recurrent endometrial cancer initially treated by hysterectomy and radiotherapy

2004 ◽  
Vol 14 (4) ◽  
pp. 673-676 ◽  
Author(s):  
P. Van Dam ◽  
H. Sonnemans ◽  
P.-J. Van Dam ◽  
D. Smet ◽  
L. Verkinderen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Sentinel Node ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Pelvic Lymphadenectomy ◽  
Sentinel Node Detection ◽  
Lymph Node Sampling ◽  
Sentinel Node Identification ◽  
Grade Ii ◽  
The Right

This is the first article reporting sentinel node identification in a patient with endometrial cancer recurring in the vagina. A 79-year-old woman presented with a midvaginal recurrence of a stage IB, grade II endometroid carcinoma that had been treated 3 years earlier by a total abdominal hysterectomy, bilateral salpingoophorectomy, and pelvic lymph node sampling, followed by adjuvant brachytherapy to the vaginal vault. A staging examination under anesthetic was performed. Preoperatively, 60-MBq technetium-labeled nannocolloid was injected in the mucosa at 3, 6, 9, and 12 o'clock just adjacent to the tumor recurrence. Three sentinel nodes were detected, respectively, in the left obturator fossa (two) and the right external iliac region, using a laparoscopic probe (Navigator) and removed for pathological assessment. As they proved to be negative, the patient underwent a total vaginectomy, parametrectomy with pelvic lymphadenectomy. The tumor was completely removed, and all lymph nodes proved to be negative. The accuracy of sentinel node identification in patients with recurrent gynecological tumors needs further evaluation. This unique case shows that sentinel node detection is possible after previous radiotherapy and surgery and hopes to stimulate further research in this field.

scholarly journals Transformation of Seborrheic Keratosis into Bowenoid Actinic Keratosis via Three Steps of Histological Change in a Patient with Rheumatoid Arthritis Treated with Multiple Immunosuppressants

2020 ◽  
Vol 12 (1) ◽  
pp. 19-24
Author(s):  
Masahiro Oka ◽  
Yuki Yamamoto ◽  
Miki Fujii
Keyword(s):  
Rheumatoid Arthritis ◽  
Skin Lesion ◽  
Malignant Transformation ◽  
Actinic Keratosis ◽  
Histological Change ◽  
The Other ◽  
Lateral Side ◽  
Seborrheic Keratosis ◽  
History Of ◽  
The Right

We report a case of seborrheic keratosis (SK) that transformed into bowenoid actinic keratosis (AK) via three steps of histological change in a 77-year-old woman. The patient presented with a multiple-year history of a brownish lesion on the right cheek. She reported that some months earlier she had noted a pinkish lesion developing within the brownish lesion. She had also been treated with several immunosuppressants for rheumatoid arthritis for many years. Physical examination revealed a nodule measuring 13 × 12 mm on the lateral side of the right upper cheek. The lesion comprised three regions: a brownish hyperkeratotic region in the upper portion; a pinkish region in the lower portion; and a slightly dented, band-like region between the other two regions. Histopathologically, the specimen consisted of four zones: SK comprising basaloid cells; SK composed of squamoid cells; atrophic AK; and bowenoid AK. The zones of SK with basaloid cells and squamoid cells clinically corresponded to the brownish hyperkeratotic region. Atrophic and bowenoid AK zones corresponded to the dented, band-like region and pinkish region, respectively. Collectively, the nodular skin lesion was diagnosed as SK associated with atrophic and bowenoid AK within the SK lesion. The present case suggests that bowenoid AK developed from SK by malignant transformation via three steps of histological change. The facts that our patient had received treatment with several immunosuppressants and that no other AK lesions were evident around the AK support the notion that in this case, bowenoid AK developed from SK by malignant transformation.

scholarly journals Chronic Postoperative Pain After Hysterectomy for Endometrial Cancer: A Metabolic Profiling Study

2020 ◽  
Vol 16 ◽  
pp. 174480692092388
Author(s):  
Søren Lunde ◽  
Hien TT Nguyen ◽  
Kristian K Petersen ◽  
Lars Arendt-Nielsen ◽  
Henrik B Krarup ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Postoperative Pain ◽  
Metabolic Profiling ◽  
Predictive Accuracy ◽  
Laparoscopic Hysterectomy ◽  
Resonance Spectroscopy ◽  
Analysis Model ◽  
Chronic Postoperative Pain ◽  
Robot Assisted ◽  
Explorative Study

Introduction One out of seven women will develop a state of chronic postoperative pain following robot-assisted hysterectomy for endometrial cancer. Recently, metabolic studies have indicated that circulating lipids and lipoproteins could act as nociceptive modulators and thereby influence the induction and perpetuation of pain. The objectives of this explorative study were (1) to examine the preoperative serologic variations in concentrations of lipids, lipoproteins, and various low‐molecular metabolites in patients with and without chronic postoperative pain after robot-assisted hysterectomy and (2) to explore if any of these serological biomarkers were predictive for development of chronic postoperative pain. Materials and Methods The study was designed as a nested case–control study within a cohort of women treated for endometrial cancer with robot-assisted laparoscopic hysterectomy. Twenty-six women with chronic postoperative pain were matched on age and body mass index with fifty-two controls without chronic postoperative pain, and metabolic profiling of preoperatively drawn blood samples from a biobank was performed by means of nuclear magnetic resonance spectroscopy. Results Nineteen metabolites, including cholesterol, cholesteryl ester, linoleic acid, phospholipids, lipids, and triglycerides had statistically significant higher concentrations in a subgroup of patients who would develop chronic postoperative pain on a later stage compared to the group of patients who would not develop chronic postoperative pain ( p <  0.05). A sparse Partial Least Squares-Discriminant Analysis model explained 38.1% of the variance and had a predictive accuracy of 73.1%. Conclusions This explorative study substantiates the hypothesis that certain lipids, lipoproteins, and fatty acids are associated with chronic postoperative pain.

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