Management of an unusual cause of life-threatening haemoptysis: a multidisciplinary approach

2021 ◽  
Vol 14 (5) ◽  
pp. e240448
Author(s):  
Kim Pramanik ◽  
Philip Webb ◽  
RanaShoaib Hamid
Keyword(s):  
Cystic Fibrosis ◽  
Interventional Radiology ◽  
Tranexamic Acid ◽  
Medical Management ◽  
Multidisciplinary Approach ◽  
Bronchial Artery ◽  
Successful Resuscitation ◽  
Emergency Medical ◽  
Life Threatening

We present to you a case of life-threatening haemoptysis secondary to non-cystic fibrosis bronchiectasis complicated by bronchial artery pseudoaneurysms. We discuss this patient’s emergency medical management using intravenous tranexamic acid, which resulted in successful resuscitation and eventual survival, and evaluate the need for urgent anaesthetic and interventional radiology input in such a case.

Extrapleural Bronchial Artery Ligation for Life-Threatening Hemoptysis in Cystic Fibrosis

Angiology ◽  
2000 ◽  
Vol 51 (9) ◽  
pp. 787-792 ◽  
Author(s):  
H.K. Kaukuntla ◽  
K.M.A. Amer ◽  
D. Honeybourne ◽  
D.E. Stableforth ◽  
J.F. Khalil-Marzouk
Keyword(s):  
Cystic Fibrosis ◽  
Bronchial Artery ◽  
Artery Ligation ◽  
Life Threatening

scholarly journals Medical Management of Placenta Accreta with Methotrexate: Review of Two Cases

2015 ◽  
Vol 7 (2) ◽  
pp. 86-88
Author(s):  
Yoginder Singh ◽  
Vinod Raghav ◽  
A Kapur
Keyword(s):  
South Asian ◽  
Medical Management ◽  
Multidisciplinary Approach ◽  
Placenta Accreta ◽  
Cesarean Hysterectomy ◽  
Adherent Placenta ◽  
Child Bearing ◽  
Life Threatening ◽  
Previous Cesarean

ABSTRACT Placenta accreta is a potentially life-threatening obstetric condition that requires a multidisciplinary approach for its management. The incidence of placenta accreta has increased over the years. Women at greatest risk of placenta accreta are those who have myometrial damage caused by a previous cesarean delivery. Although recognized obstetric risk factors allow the identification of most cases during the antepartum period, the diagnosis is occasionally discovered at the time of delivery when there is difficulty in delivery of placenta. In general, the recommended management of suspected placenta accreta is planned preterm cesarean hysterectomy with the placenta left in situ because attempts at removal of the placenta are associated with significant hemorrhagic morbidity. Recently, adjuvant therapy with methotrexate has been used in the treatment of morbidly adherent placenta in patients desiring further child bearing. We present two cases where medical management was successful. How to cite this article Singh Y, Raghav V, Kapur A. Medical Management of Placenta Accreta with Methotrexate: Review of Two Cases. J South Asian Feder Obst Gynae 2015;7(2):86-88.

PRO–CF–MED, Clinical Proof of concept for a RNA–targeting Oligonucleotide for a Cystic fibrosis–F508del MEDication, Horizon2020

Impact ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. 52-54
Author(s):  
Nicolas Lamontagne
Keyword(s):  
Cystic Fibrosis ◽  
Transmembrane Conductance Regulator ◽  
Transmembrane Conductance ◽  
Rna Targeting ◽  
Threatening Condition ◽  
Life Threatening ◽  
Cftr Protein ◽  
Disease Modifying ◽  
Cystic Fibrosis Transmembrane ◽  
Specific Challenge

Cystic fibrosis (CF) is a progressive life–shortening disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leading to a dysfunctional CFTR protein. The disease affects over 70,000 patients worldwide and while many mutations are known, the F508del mutation affects 90% of all patients. The absence of CFTR in the plasma membrane leads to a dramatic decrease in chloride efflux, resulting in viscous mucus that causes severe symptoms in vital organs like the lungs and intestines. For CF patients that suffer from the life threatening F508del mutation only palliative treatment exist. PRO–CF–MED addresses the specific challenge of this call by introducing the first disease modifying medication for the treatment of the CF patients with F508del mutation. The PRO–CF–MED project has been designed to assess the potential clinical efficacy of QR–010, an innovative disease modifying oligonucleotide–based treatment for F508del patients. Partners within PRO–CF–MED have generated very promising preclinical evidence for QR–010 which allows for further clinical assessment of QR–010 in clinical trials. PRO–CF–MED will enable the fast translation of QR–010 towards clinical practice and market authorisation. PRO–CF–MED has the potential to transform this life–threatening condition into a manageable one.

Multidisciplinary Management of Postoperative Pancreatic Fistula

2021 ◽  
Author(s):  
Alexa Glencer ◽  
Kim Kirkwood ◽  
Adam Schwertner ◽  
Cody Keller ◽  
Mustafa Arain ◽  
...  
Keyword(s):  
Interventional Radiology ◽  
Pancreatic Fistula ◽  
Multidisciplinary Approach ◽  
Postoperative Morbidity ◽  
Postoperative Pancreatic Fistula ◽  
Significant Source ◽  
Successful Outcome ◽  
Multidisciplinary Management ◽  
Economic Strain ◽  
Pancreatic Fistulas

AbstractPostoperative pancreatic fistulas are complex, challenging problems that often take weeks, months, or longer to resolve. Multiple interventions may be required to achieve a successful outcome. As such, resolution typically involves a multidisciplinary approach by a team whose skills include abdominal imaging, specialized surgery, advanced endoscopy, and interventional radiology. Intensive resources and time are often required, which impacts both patients and their caregivers. While treatment(s) continue to improve, a primary goal of research efforts in this area is the prevention of this significant source of postoperative morbidity, mortality, and economic strain.

Outcomes Following Bronchial Artery Embolisation for Haemoptysis in Cystic Fibrosis

2017 ◽  
Vol 40 (8) ◽  
pp. 1164-1168 ◽  
Author(s):  
W. G. Flight ◽  
P. J. Barry ◽  
R. J. Bright-Thomas ◽  
S. Butterfield ◽  
R. Ashleigh ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bronchial Artery ◽  
Bronchial Artery Embolisation

Control of Tubercular Haemoptysis by Bronchial Artery Embolization

1997 ◽  
Vol 27 (3) ◽  
pp. 149-150 ◽  
Author(s):  
Sanjeev Mani ◽  
Rajesh Mayekar ◽  
Ravi Rananavare ◽  
Deepti Maniar ◽  
J Mathews Joseph ◽  
...  
Keyword(s):  
Bronchial Artery ◽  
Bronchial Artery Embolization ◽  
Artery Embolization ◽  
Selective Embolization ◽  
Bronchial Arteries ◽  
Bleeding Vessel ◽  
Life Threatening ◽  
Abnormal Bleeding ◽  
Recurrent Haemoptysis

Thirty-seven patients presenting with massive or recurrent haemoptysis secondary to tuberculous aetiology were subjected to bronchial artery angiography. Of these, failure to catheterize the bleeding vessel occurred in two patients while embolization was withheld in two patients due to the presence of anterior spinal artery arising from a common intercosto-bronchial trunk. Immediate arrest of bleeding was performed in the remaining 33 patients by selective embolization of the abnormal bronchial arteries with a resorbable material (Gelfoam). Regular follow up for a duration of 6 months after the procedure revealed relapse of haemoptysis in four patients; three were treated by re-embolization of the abnormal bleeding vessels while one patient died due to aspiration immediately on admission. No recurrence of bleeding was seen in the remaining 29 patients. It is concluded that bronchial artery embolization is an effective treatment for immediate control of life-threatening haemoptysis.

Catastrophic Antiphospholipid Syndrome Following Lower Extremity Arterial Bypass Surgery: Case Report and Evidence Review

2021 ◽  
pp. 153857442110462
Author(s):  
Ahmed A. Sorour ◽  
Levester Kirksey ◽  
Sarah Keller ◽  
Michael S. O’Connor ◽  
Sean P. Lyden
Keyword(s):  
Case Report ◽  
Lower Extremity ◽  
Antiphospholipid Syndrome ◽  
Current Literature ◽  
Bypass Surgery ◽  
Multidisciplinary Approach ◽  
Catastrophic Antiphospholipid Syndrome ◽  
Diagnosis And Management ◽  
Life Threatening ◽  
Evidence Review

Catastrophic antiphospholipid syndrome (CAPS) is a rare life threatening presentation of antiphospholipid syndrome. Surgery has been proposed as one of the triggering factors for this life threatening entity. There are no detailed published reports in the current literature describing CAPS as a complication after surgery. We report a case of a 21 year old that developed CAPS postoperatively and discuss the multidisciplinary approach for diagnosis and management.

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