Advances in dry eye imaging: the present and beyond

2017 ◽  
Vol 102 (3) ◽  
pp. 295-301 ◽  
Author(s):  
Tommy C Y Chan ◽  
Kelvin H Wan ◽  
Kendrick C Shih ◽  
Vishal Jhanji
Keyword(s):  
Dry Eye ◽  
Dynamic Properties ◽  
Imaging Techniques ◽  
Meibomian Gland ◽  
Optical Quality ◽  
Eye Disease ◽  
In Vivo Confocal Microscopy ◽  
Non Invasive ◽  
Breakup Time

New advances in imaging allow objective measurements for dry eye as well as define new parameters that cannot be measured by clinical assessment alone. A combination of these modalities provides unprecedented information on the static and dynamic properties of the structural and functional parameters in this multifactorial disease. A literature search was conducted to include studies investigating the use of imaging techniques in dry eye disease. This review describes the application of non-invasive tear breakup time, optical coherence tomography, meibomian gland imaging, interferometry, in vivo confocal microscopy, thermography and optical quality assessment for this condition.

scholarly journals Advances in the Noninvasive Diagnosis of Dry Eye Disease

2021 ◽  
Vol 11 (21) ◽  
pp. 10384
Author(s):  
Luca Di Cello ◽  
Marco Pellegrini ◽  
Aldo Vagge ◽  
Massimiliano Borselli ◽  
Lorenzo Ferro Desideri ◽  
...  
Keyword(s):  
Dry Eye ◽  
Anterior Segment ◽  
Tear Film ◽  
Optical Quality ◽  
Dry Eye Disease ◽  
Diagnostic Tools ◽  
Eye Disease ◽  
Non Invasive ◽  
Integrated Devices

Dry eye disease (DED) is a multifactorial disease that represents one of the most common ophthalmologic conditions encountered in everyday clinical practice. Traditional diagnostic tests for DED, such as subjective questionnaires, tear film break-up time and the Schirmer test, are often associated with poor reproducibility and reliability, which make the diagnosis, follow-up, and management of the disease challenging. New advances in imaging technologies enable objective and reproducible measurements of DED parameters, thus making the diagnosis a multimodal imaging-based process. The aim of this review is to summarize all the current and emerging diagnostic tools available for the diagnosis and monitoring of DED, such as non-invasive tear breakup time, thermography, anterior segment optical coherence tomography, meibography, interferometry, in vivo confocal microscopy, and optical quality assessment. Although there is not a gold standard imaging technique, new multi-imaging-integrated devices are precious instruments to help clinicians to better cope with the diagnostic complexity of DED.

scholarly journals Objective Imaging Diagnostics for Dry Eye Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Sang Beom Han ◽  
Yu-Chi Liu ◽  
Karim Mohamed-Noriega ◽  
Louis Tong ◽  
Jodhbir S. Mehta
Keyword(s):  
Dry Eye ◽  
Clinical Symptoms ◽  
Imaging Techniques ◽  
Anterior Segment ◽  
Tear Film ◽  
Optical Quality ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Break Up

Traditional diagnostic tests for dry eye disease (DED), such as fluorescein tear film break-up time and the Schirmer test, are often associated with poor reproducibility and reliability, which make the diagnosis, follow-up, and management of the disease challenging. Advances in ocular imaging technology enables objective and reproducible measurement of changes in the ocular surface, tear film, and optical quality associated with DED. In this review, the authors will discuss the application of various imaging techniques, such as, noninvasive tear break-up time, anterior segment optical coherence tomography, in vivo confocal microscopy, meibography, interferometry, aberrometry, thermometry, and tear film imager in DED. Many studies have shown these devices to correlate with clinical symptoms and signs of DED, suggesting the potential of these imaging modalities as alternative tests for diagnosis and monitoring of the condition.

scholarly journals Confocal microscopy in ocular surface disease

2017 ◽  
Vol 10 (1) ◽  
pp. 23-30
Author(s):  
Vitaly V Potemkin ◽  
Tatyana S Varganova ◽  
Elena V Ageeva
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Eye Disease ◽  
Disease Monitoring ◽  
Efficacy Evaluation ◽  
Clinical Method ◽  
Non Invasive ◽  
Mode A

Confocal microscopy is a modern clinical method, which provides in real-time mode a non-invasive possibility for in vivo imaging of the cornea, limbus, and conjunctiva. In several ocular surface disorders, this method could be applied for diagnostic purposes, as well as for disease monitoring and treatment efficacy evaluation. In present article, we discuss main changes observed by confocal microscopy in patients with dry eye, and propose our examination algorithm of ocular surface investigation in dry eye disease.

scholarly journals In vivo Confocal Microscopy Evaluation of Meibomian Gland Dysfunction in Dry Eye Patients with Different Symptoms

2016 ◽  
Vol 129 (21) ◽  
pp. 2617-2622 ◽  
Author(s):  
Hui Zhao ◽  
Jing-Yao Chen ◽  
Yu-Qian Wang ◽  
Zhi-Rong Lin ◽  
Shen Wang
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
In Vivo Confocal Microscopy
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