scholarly journals Comparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: a randomised, controlled clinical trial

2019 ◽  
Vol 104 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Daliya Dzhaber ◽  
Osama Mustafa ◽  
Fares Alsaleh ◽  
Aleksandra Mihailovic ◽  
Yassine J Daoud
Keyword(s):  
Clinical Trial ◽  
Endothelial Cell ◽  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Controlled Clinical Trial ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled

Background/AimTo identify changes in endothelial cell density (ECD) and central corneal thickness (CCT) in eyes undergoing femtosecond laser-assisted cataract surgery (FLACS) compared with conventional phacoemulsification surgery (CPS).MethodsThis is an intraindividual randomised, controlled clinical trial. One eye was randomised to receive FLACS, while the contralateral eye of the same patient received CPS. The femtosecond laser pretreatment included creating main and side-port corneal incisions, capsulotomy and lens fragmentation. Non-contact endothelial cell microscopy and pachymetry were performed preoperatively and at postoperative day 1, week 1, month 1 and month 3.ResultsA total of 134 paired eyes from 67 patients were included in the analysis. ECD was not significantly different between the two groups at either postoperative month 1 (2370±580 cells/mm2 and 2467±564 cells/mm2 in FLACS and CPS groups, respectively; p=0.18) or at postoperative month 3 (2374±527 cells/mm2 and 2433±526 cells/mm2 in FLACS and CPS groups, respectively; p=0.19). No significant difference was observed in the mean CCT values between the two groups over the follow-up period (p>0.05).ConclusionPostoperative corneal ECD and CCT were comparable between FLACS and CPS during the 3 months’ follow-up period.

Visual and refractive outcomes and complications in femtosecond laser-assisted versus conventional phacoemulsification cataract surgery: findings from a randomised, controlled clinical trial

2020 ◽  
pp. bjophthalmol-2019-314548
Author(s):  
Daliya Dzhaber ◽  
Osama M Mustafa ◽  
Fares Alsaleh ◽  
Yassine J Daoud
Keyword(s):  
Clinical Trial ◽  
Visual Acuity ◽  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Controlled Clinical Trial ◽  
Distance Visual Acuity ◽  
Refractive Outcomes ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled

Background/aimTo compare visual and refractive outcomes, changes in intraocular pressure (IOP), and complications of femtosecond laser-assisted cataract surgery (FLACS) to conventional phacoemulsification surgery (CPS) in paired eyes from the same patients.MethodsThis is a secondary analysis of an intraindividual, randomised, controlled clinical trial including 110 paired eyes from 55 patients that were randomised into either FLACS or CPS groups. Outcomes were recorded at baseline and postoperatively during a 3-month follow-up period.ResultsUncorrected distance visual acuity and corrected distance visual acuity were similar between FLACS and CPS over the follow-up period (p>0.05). The mean absolute refractive error was not significantly different between the two groups at postoperative month 1 (POM1) (0.3±0.2 D in FLACS vs 0.4±0.3 D in CPS, p=0.18) and month 3 (POM3) (0.3±0.3 D in FLACS vs 0.3±0.3 D in CPS, p=0.71). IOP was statistically higher in the FLACS group on postoperative day 1 (20.6±5.7 mm Hg for FLACS and 18.0±4.9 mm Hg for CPS, p=0.01). However, it was similar between the two groups subsequently (p>0.05). Intraoperatively, one case of posterior capsular block syndrome was observed in the FLACS group. Postoperatively, one case of newly developed glaucoma was observed in the FLACS group and one case of retinal tears in the CPS group.ConclusionThe 3-month postoperative refractive and visual outcomes were comparable between FLACS and CPS in paired eyes from the same patients. Complication rate was low in the study population.

scholarly journals New ophthalmic dual-viscoelastic device in cataract surgery: a comparative study

2019 ◽  
Vol 4 (1) ◽  
pp. e000280
Author(s):  
Gaspare Monaco ◽  
Mariangela Gari ◽  
Silvia Pelizzari ◽  
Arianna Lanfranchi ◽  
Giada Ruggi ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cataract Surgery ◽  
Corneal Thickness ◽  
Cell Loss ◽  
Intraocular Inflammation ◽  
Significant Difference ◽  
Corrected Distance Visual Acuity ◽  
Randomised Controlled ◽  
Controlled Clinical Study

ObjectiveTo compare the performance and safety in cataract surgery of two ophthalmic viscoelastic devices (OVDs), each having separate dispersive and cohesive characteristics and different concentrations.Methods and analysisIn this prospective, randomised, controlled clinical study, one eye of each patient was injected with OVD1 (Viscopack14) or OVD2 (DuoVisc) during phacoemulsification and intraocular lens implantation. Endothelial cell count, intraocular pressure (IOP), central corneal thickness (CCT), intraocular inflammation and corrected distance visual acuity (CDVA) were compared 3 months postoperatively.ResultsThe study enrolled 127 patients. Randomisation assigned 50 eyes of as many patients to each arm of the study. The postoperative mean endothelial cell loss was 14.4% and 7.1% from baseline in the OVD1 and OVD2 groups, respectively (p=0.08). The incidence of IOP spikes at 2 hours was 0% and 8%, respectively (p=0.02). There were intergroup differences in postoperative IOP values, the OVD2 group showed significantly higher values at all of the follow-up visits starting from the 24 hours examination (p<0.05). There was no statistically significant difference in the CCT, intraocular inflammation and CDVA at the end of follow-up.ConclusionBoth OVDs showed similar clinical performances and were equally effective during cataract surgery. Viscopack14 showed more corneal endothelial cell reduction, while DuoVisc had more occurrences of IOP values and spikes. Future studies are mandatory to support these preliminary results.

scholarly journals Impact of oral rehabilitation on the quality of life of partially dentate elders in a randomised controlled clinical trial: 2 year follow-up

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0203349 ◽  
Author(s):  
Gerald McKenna ◽  
Patrick Finbarr Allen ◽  
Martina Hayes ◽  
Cristiane DaMata ◽  
Ciaran Moore ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Oral Rehabilitation ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled ◽  
Partially Dentate

EFFECT OF ASPIRIN AND ASPIRIN COMBINED WITH DIPYRIDAMOLE IN EARLY DIABETIC RETINOPATHY

1987 ◽  
Author(s):  
M Samama ◽  
C E Baudoin
Keyword(s):  
Clinical Trial ◽  
Diabetic Retinopathy ◽  
Clinical Relevance ◽  
Antiplatelet Agents ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled

In a double blind randomised controlled clinical trial the effect of antiplatelet agents (aspirin 330 mg × 3 × day) or in combination with dipyridamole (75 mg 3 × day) versus placebo, was tested in 475 patients with early diabetic retinopathy. Patients were follewed fourmonthly for 3 years. Ophtalmological examinations were carried out initially and at yearly intervals. The assessment of retinopathy was based on changes in the number of microaneurysms (MA) present in the macular field as seen on fluorescein angiograms over a period of three years. Forty one patients did not complete the study. Among the others at least three readable initial and yearly angiograms were available on 420 patients who had a 3 year follow up (266 insulin treated and 154 non insulin treated). The results are based on these patients.It is concluded that either Aspirin alone or in conjunction with dipyridamole significantly slows down the progression of MA evolution in early diabetic retinopathy. Because of the very small, although significant changes, the clinical relevance of these drugs has not been established.

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