Profile of retinal nerve fibre layer symmetry in a multiethnic Asian population: the Singapore Epidemiology of Eye Diseases study

2019 ◽  
Vol 104 (6) ◽  
pp. 836-841 ◽  
Author(s):  
Yijin Tao ◽  
Yih Chung Tham ◽  
Miao Li Chee ◽  
Shivani Majithia ◽  
Sahil Thakur ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Axial Length ◽  
Asian Population ◽  
Retinal Nerve Fibre Layer ◽  
Eye Diseases ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Disc Area ◽  
Nerve Fibre Layer

BackgroundTo examine the normative profile and determinants of retinal nerve fibre layer (RNFL) symmetry in a non-glaucoma, multiethnic Asian population.MethodsChinese, Malay and Indian adults aged ≥40 years were recruited from the Singapore Epidemiology of Eye Diseases study. Participants underwent standardised systemic and ocular examinations. RNFL thickness was obtained using a spectral-domain optical coherence tomography (Cirrus HD-OCT). RNFL symmetry (in %) was calculated based on Pearson correlation coefficient between the RNFL thickness profiles of the right and left eyes. Multivariable linear regression analysis was used to investigate the associations between ocular and systemic factors with RNFL symmetry.Results4211 participants (1227 Chinese, 1245 Malays, 1739 Indians) were included. The mean RNFL symmetry was 86.7%±8.5% in Chinese, 84.7%±10.2% in Malays and 84.0%±10.7% in Indians. The fifth percentile limit of RNFL symmetry was 71.2% in Chinese, 65.0% in Malays and 62.0% in Indians. In multivariable analysis adjusting for age, gender, ethnicity, hypertension, diabetes, hyperlipidaemia, intereye absolute differences in intraocular pressure (IOP), axial length and disc area, Malays (β=−0.9; p=0.03) and Indians (β=−1.76; p<0.001) were found to have lower RNFL symmetry compared with Chinese. Older age, greater intereye differences in IOP, axial length and disc area were significantly associated with lower RNFL symmetry (all p≤0.003).ConclusionsIn non-glaucoma individuals, intereye RNFL profile is less symmetric in Malays and Indians than that in Chinese. This also suggests that current commercial optical coherence tomography’s deployment of a single, universal RNFL symmetry cut-off for glaucoma detection is flawed, and ethnic-specific cut-off is warranted.

scholarly journals Thinner temporal peripapillary retinal nerve fibre layer in Stargardt disease detected by optical coherence tomography

2020 ◽  
Author(s):  
Michael Reich ◽  
Jan Lübke ◽  
Lutz Joachimsen ◽  
Julia Stifter ◽  
Sebastian Küchlin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
Stargardt Disease ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Manual Adjustment ◽  
Nerve Fibre Layer

Abstract Purpose To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness measured by spectral domain optical coherence tomography (OCT) in patients with Stargardt disease (STGD). Methods A cross-sectional, monocentric, observational case-control study. Twenty patients (39 eyes) with ABCA4 mutations graded according to the Fishman STGD classification were included. RNFL measurement was performed using Heidelberg Spectralis SD-OCT. RNFL thickness in STGD patients was compared to age-matched data of healthy individuals provided by the device’s manufacturer. A manual readjustment of the optic disc-fovea angle was performed when needed. Results The mean age at first diagnosis of STGD was 22.9 years (range 9 to 50) and 39.1 years (range 18 to 74) at the time of examination. Thirty-nine percent of eyes (15 eyes) needed manual adjustment of the optic disc-fovea angle due to malfixation of the patients during OCT. The temporal quadrant corresponding to the macula showed a RNFL 16% thinner than controls (mean − 12 μm, 95%CI − 9 to −15 μm). However, global RNFL thickness did not differ from controls due to increased RNFL thickness of 12% in the nasal sectors. Duration and stage of STGD were not correlated to thinner RNFL. Conclusion STGD seems to be associated with thinner peripapillary RNFL in the sector of axons projecting to the degenerated macular area. It is yet unclear as to whether this results from anterograde transneuronal degeneration of direct injury to retinal ganglion cells.

The volume of peripapillary vessels within the retinal nerve fibre layer: an optical coherence tomography angiography study of normal subjects

2017 ◽  
Vol 102 (5) ◽  
pp. 611-621 ◽  
Author(s):  
Davide Allegrini ◽  
Giovanni Montesano ◽  
Paolo Fogagnolo ◽  
Alfredo Pece ◽  
Roberta Riva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fibre ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Tissue ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
The Mean ◽  
Nerve Fibre Layer

Background/aimsTo investigate the contribution of vascular volume calculated by optical coherence tomography angiography (OCTA) to the measurement of peripapillary retinal nerve fibre layer (RNFL) thickness.MethodsWe used OCTA scans to build volumetric maps of the RNFL angiograms by thresholding the decorrelation images and summing the number of white pixels along the z-axis at each location. We used these maps to calculate the contribution of the vascular tissue to the RNFL thickness.ResultsWe analysed 51 eyes from 36 subjects. The mean RNFL volume calculated on the peripapillary region was 0.607±0.045 mm3 and the mean vessel volume was 0.217±0.035 mm3, with a mean vessel/total RNFL ratio of 35.627%±3.942%. When evaluated in the peripapillary circular section, the total contribution of the vascular tissue to the global RNFL thickness was 29.071%±3.945%. The superior and inferior sectors showed the highest percentage of vascular tissue within the RNFL circular profile (31.369% and 34.788% respectively).ConclusionsWe found that the vascular contribution to the RNFL thickness is 29.07±3.945%. This is much higher than what has been reported from calculations made on the structural OCT alone (13% reported by Hood et al and 11.3%±1.6% for the Cirrus OCT and 11.8%±1.4% for the Spectralis OCT reported by Patel et al). We conclude that evaluation of the vascular tissue contribution to the RNFL thickness with OCTA might be useful when performing precise quantification of the neuronal tissue.

scholarly journals COMPARISION OF RETINAL NERVE FIBRE LAYER THICKNESS BY CIRRUS HD-OPTICAL COHERENCE TOMOGRAPHY IN EMMETROPIC, MYOPIC AND HYPEROPIC EYES

2021 ◽  
Vol 9 (01) ◽  
pp. 62-71
Author(s):  
S. Mounica ◽  
◽  
B.V. Kranthi ◽  
M. Lakshmi Sarvani ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
College Hospital ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Department Of Ophthalmology ◽  
Nerve Fibre Layer

Purpose: The purpose of our study is to compare the average peripapillary retinal nerve fibre layer thickness by cirrus HD-Optical coherence tomography in emmetropic, axial myopic and axial hyperopic cases. Materials And Methods: Total of 120 subjects aged between 10 to 50 years were enrolled in this study, divided into 3 groups with 40 in each, namely group 1 - emmetropia, group 2- myopia >2.5 D and group 3-hypermetropia>2.5 D. In which, 58 (48.3%) were females and 62 (51.7%) were males. This study was done in the Department of Ophthalmology, Santhiram Medical College Hospital Nandyal,from October 2019 to March 2020. The average as well as quadratic assessment of peripapillary RNFL thickness by cirrus-HD optical coherence tomography and comparison among these 3 groups. Observation And Results: In our study, average peripapillary RNFL thickness between emmetropic, myopic and hyperopic groups was found to be statistically significant. The average peripapillary RNFL thickness was thickest in the hyperopic group (102.95 ± 5.629, n=40), followed by the emmetropic group (102.55 ± 5.505, n=40), and then the myopic group (83.38 ± 3.726, n=40) (all P<0.0001) . And in all four RNFL quadrants, myopic group showed thinning when compared to Emmetropic and hyperopic group (p<0.001).But hyperopic group showed thicker RNFL than emmetropic group only in temporal quadrants in right eye(p<0.001)and nasal and superior quadrants in left eye (p=0.017) Conclusion: In our study, average as well as in all the four quadrants peripapillary RNFL thickness shows highly significant results between emmetropia, myopia and hyperopia. When compared with emmetropia, RNFL thickness being thinnest in myopic group, and slightly thicker RNFL thickness in hyperopic group.

scholarly journals Retinal nerve fibre layer thickness of black and Indian myopic students at the University of KwaZulu-Natal

2015 ◽  
Vol 74 (1) ◽  
Author(s):  
Chanel Murugan ◽  
Bomikazi Z. Golodza ◽  
Kaveshni Pillay ◽  
Brightness N. Mthembu ◽  
Praneal Singh ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Racial Differences ◽  
Axial Length ◽  
Total Sample ◽  
Retinal Nerve Fibre Layer ◽  
Spherical Equivalent ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Nerve Fibre Layer ◽  
The University

Aim: To compare retinal nerve fibre layer (RNFL) thickness in black and Indian myopic students at the University of KwaZulu-Natal.Method: Eighty (40 black and 40 Indian) participants of both genders and aged between 19 and 24 years (mean and standard deviation: 21 ± 1.7 years) were included in the study. Refractive errors were assessed with the Nidek AR-310A auto-refractor and via subjective refraction. RNFL thicknesses were then measured using the iVue-100 optical coherence tomography device. Axial lengths were measured with the Nidek US-500 A-scan ultrasound device. Data were analysed by descriptive statistics, t-tests, Pearson’s correlation coefficients and regression analysis.Results: The mean myopic spherical equivalent was significantly more negative amongst the Indian (-2.42 D ± 2.22 D) than amongst the black (-1.48 D ± 1.13 D) (p = 0.02) participants.The mean axial length was greater amongst the black (23.35 mm ± 0.74 mm) than amongst the Indian (23.18 mm ± 0.87 mm) participants but the difference was not significant. In the total sample (n = 80), the average global RNFL thickness ranged from 87 μm to 123 μm (105 μm ±9 μm). Mean global RNFL thickness was slightly greater amongst black (108 μm ± 7 μm) than amongst Indian (102 μm ± 9 μm) (p = 0.00) participants. Mean global RNFL thickness was similar for male (106 μm ± 7 μm) and female (105 μm ± 10 μm) (p = 0.79) participants.A positive and significant association between myopic spherical equivalent and global RNFL thickness was found for the total sample (r = 0.36, p = 0.00) and for Indians (r = 0.33, p = 0.04)but not for the black (r = 0.25, p = 0.13) participants. There was a negative and significant correlation between axial length and global RNFL thickness amongst the Indian participants (r = -0.34, p = 0.03) but not amongst the total sample (r = -0.12, p = 0.30) or the black (r = 0.06, p = 0.73) participants.Conclusion: The findings suggest that racial differences in RNFL thickness need to be considered in the clinical examination and screening for glaucoma and other optic nerve pathologies amongst black and Indian people. Additionally, the possible influences ofrefractive error and axial length should be considered when evaluating RNFL thickness.

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